ID HG2A_HUMAN STANDARD; PRT; 232 AA. AC P04233; DT 20-MAR-1987 (REL. 04, CREATED) DT 20-MAR-1987 (REL. 04, LAST SEQUENCE UPDATE) DT 01-FEB-1991 (REL. 17, LAST ANNOTATION UPDATE) DE HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, GAMMA CHAIN PRECURSOR (HLA-DR DE ANTIGENS ASSOCIATED INVARIANT CHAIN) (P33). GN DHLAG. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RM 86093681 RA KUDO J., CHAO L.Y., NARNI F., SAUNDERS G.F.; RL NUCLEIC ACIDS RES. 13:8827-8841(1985). RN [2] RP SEQUENCE FROM N.A. RM 84207945 RA STRUBIN M., MACH B., LONG E.O.; RL EMBO J. 3:869-872(1984). RN [3] RP SEQUENCE FROM N.A. RM 86233451 RA O'SULLIVAN D.M., LARHAMMAR D., WILSON M.C., PETERSON P.A., RA QUARANTA V.; RL PROC. NATL. ACAD. SCI. U.S.A. 83:4484-4488(1986). CC -!- FUNCTION: IT IS THOUGHT THAT THE GAMMA-CHAIN PROTEIN IS INVOLVED CC IN THE ASSEMBLY OF CLASS II HLA-DR HETERODIMERS AND THEIR CC TRANSPORT TO THE SURFACE. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X03339; HSMHCGE1. DR EMBL; X03340; HSMHCGE2. DR EMBL; X00497; HSHL05. DR PIR; A30060; HLHUG. DR MIM; 142790; TENTH EDITION. DR PROSITE; PS00484; THYROGLOBULIN_1. KW GLYCOPROTEIN; MHC; PROTEOGLYCAN; TRANSMEMBRANE. FT DOMAIN 1 46 CYTOPLASMIC. FT TRANSMEM 47 72 FT DOMAIN 73 232 EXTRACELLULAR. FT CARBOHYD 130 130 FT CARBOHYD 136 136 FT CARBOHYD 218 218 GLYCOSAMINOGLYCAN. FT CONFLICT 167 167 T -> R (IN REF. 2). SQ SEQUENCE 232 AA; 26343 MW; 298477 CN; MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLTHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ KPTDAPPKES LELEDPSSGL GVTKQDLGPV PM //