ID HG2A_HUMAN STANDARD; PRT; 296 AA. AC P04233; Q14597; Q29832; Q8WLP6; DT 20-MAR-1987 (Rel. 04, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 15-SEP-2003 (Rel. 42, Last annotation update) DE HLA class II histocompatibility antigen, gamma chain (HLA-DR antigens DE associated invariant chain) (Ia antigen-associated invariant chain) DE (Ii) (p33) (CD74 antigen). GN CD74 OR DHLAG. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=84207945; PubMed=6586420; RA Strubin M., Mach B., Long E.O.; RT "The complete sequence of the mRNA for the HLA-DR-associated RT invariant chain reveals a polypeptide with an unusual transmembrane RT polarity."; RL EMBO J. 3:869-872(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=86093681; PubMed=3001652; RA Kudo J., Chao L.-Y., Narni F., Saunders G.F.; RT "Structure of the human gene encoding the invariant gamma-chain of RT class II histocompatibility antigens."; RL Nucleic Acids Res. 13:8827-8841(1985). RN [3] RP SEQUENCE FROM N.A. (ISOFORMS LONG AND SHORT). RC TISSUE=Liver; RX MEDLINE=86233451; PubMed=3459184; RA O'Sullivan D.M., Larhammar D., Wilson M.C., Peterson P.A., RA Quaranta V.; RT "Structure of the human Ia-associated invariant (gamma)-chain gene: RT identification of 5' sequences shared with major histocompatibility RT complex class II genes."; RL Proc. Natl. Acad. Sci. U.S.A. 83:4484-4488(1986). RN [4] RP SEQUENCE FROM N.A. (ISOFORM SHORT). RC TISSUE=Tonsil; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [5] RP SEQUENCE OF 27-96 FROM N.A. RX MEDLINE=84170234; PubMed=6324166; RA Claesson L., Larhammar D., Rask L., Peterson P.A.; RT "cDNA clone for the human invariant gamma chain of class II RT histocompatibility antigens and its implications for the protein RT structure."; RL Proc. Natl. Acad. Sci. U.S.A. 80:7395-7399(1983). RN [6] RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 103-117. RX MEDLINE=96085023; PubMed=7477400; RA Ghosh P., Amaya M., Mellins E., Wiley D.C.; RT "The structure of an intermediate in class II MHC maturation: CLIP RT bound to HLA-DR3."; RL Nature 378:457-462(1995). RN [7] RP STRUCTURE BY NMR OF 134-208. RX MEDLINE=99059718; PubMed=9843486; RA Jasanoff A., Wagner G., Wiley D.C.; RT "Structure of a trimeric domain of the MHC class II-associated RT chaperonin and targeting protein Ii."; RL EMBO J. 17:6812-6818(1998). CC -!- FUNCTION: PLAYS A CRITICAL ROLE IN MHC CLASS II ANTIGEN PROCESSING CC BY STABILIZING PEPTIDE-FREE CLASS II ALPHA/BETA HETERODIMERS IN A CC COMPLEX SOON AFTER THEIR SYNTHESIS AND DIRECTING TRANSPORT OF THE CC COMPLEX FROM THE ENDOPLASMIC RETICULUM TO COMPARTMENTS WHERE CC PEPTIDE LOADING OF CLASS II TAKES PLACE. CC -!- SUBUNIT: NONAMER COMPOSED OF THREE ALPHA/BETA/GAMMA HETEROTRIMERS. CC -!- SUBCELLULAR LOCATION: Type II membrane protein (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Long; CC IsoId=P04233-1; Sequence=Displayed; CC Name=Short; CC IsoId=P04233-2; Sequence=VSP_005331; CC -!- SIMILARITY: Contains 1 thyroglobulin type-I domain. CC -!- DATABASE: NAME=PROW; NOTE=CD guide CD74 entry; CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd74.htm". CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; K01144; AAA36304.1; -. DR EMBL; X03339; CAA27046.1; -. DR EMBL; X03340; CAA27047.1; -. DR EMBL; X00497; CAA25192.1; -. DR EMBL; X00497; CAA25193.1; -. DR EMBL; M13560; AAA36033.1; -. DR EMBL; M13555; AAA36033.1; JOINED. DR EMBL; M13556; AAA36033.1; JOINED. DR EMBL; M13558; AAA36033.1; JOINED. DR EMBL; M13559; AAA36033.1; JOINED. DR EMBL; BC018726; AAH18726.1; -. DR PIR; A30060; HLHUG. DR PDB; 1A6A; 27-MAY-98. DR PDB; 1IIE; 15-FEB-99. DR Genew; HGNC:1697; CD74. DR MIM; 142790; -. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0003821; F:class II major histocompatibility complex a...; TAS. DR InterPro; IPR000716; Thyroglobulin_1. DR Pfam; PF00086; thyroglobulin_1; 1. DR SMART; SM00211; TY; 1. DR PROSITE; PS00484; THYROGLOBULIN_1; 1. KW Glycoprotein; Chaperone; Immune response; Proteoglycan; Transmembrane; KW Alternative splicing; Signal-anchor; 3D-structure. FT DOMAIN 1 46 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 47 72 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN) FT (POTENTIAL). FT DOMAIN 73 296 EXTRACELLULAR (POTENTIAL). FT DOMAIN 103 117 CLIP. FT CARBOHYD 130 130 N-LINKED (GLCNAC...). FT CARBOHYD 136 136 N-LINKED (GLCNAC...). FT CARBOHYD 282 282 O-LINKED (GLYCOSAMINOGLYCAN). FT DOMAIN 228 271 THYROGLOBULIN TYPE I. FT VARSPLIC 209 272 Missing (in isoform Short). FT /FTId=VSP_005331. FT CONFLICT 167 167 R -> T (IN REF. 2). FT HELIX 139 149 FT TURN 151 152 FT HELIX 162 172 FT HELIX 175 194 FT TURN 195 195 SQ SEQUENCE 296 AA; 33515 MW; 27A13F252D5FB91D CRC64; MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM //