ID HG2A_HUMAN STANDARD; PRT; 296 AA. AC P04233; Q29832; DT 20-MAR-1987 (Rel. 04, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE HLA class II histocompatibility antigen, gamma chain (HLA-DR antigens DE associated invariant chain) (P33) (CD74 antigen). GN CD74 OR DHLAG. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=86093681; PubMed=3001652; RA Kudo J., Chao L.-Y., Narni F., Saunders G.F.; RT "Structure of the human gene encoding the invariant gamma-chain of RT class II histocompatibility antigens."; RL Nucleic Acids Res. 13:8827-8841(1985). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=84207945; PubMed=6586420; RA Strubin M., Mach B., Long E.O.; RT "The complete sequence of the mRNA for the HLA-DR-associated RT invariant chain reveals a polypeptide with an unusual transmembrane RT polarity."; RL EMBO J. 3:869-872(1984). RN [3] RP SEQUENCE OF 27-96 FROM N.A. RX MEDLINE=84170234; PubMed=6324166; RA Claesson L., Larhammar D., Rask L., Peterson P.A.; RT "cDNA clone for the human invariant gamma chain of class II RT histocompatibility antigens and its implications for the protein RT structure."; RL Proc. Natl. Acad. Sci. U.S.A. 80:7395-7399(1983). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=86233451; PubMed=3459184; RA O'Sullivan D.M., Larhammar D., Wilson M.C., Peterson P.A., RA Quaranta V.; RT "Structure of the human Ia-associated invariant (gamma)-chain gene: RT identification of 5' sequences shared with major histocompatibility RT complex class II genes."; RL Proc. Natl. Acad. Sci. U.S.A. 83:4484-4488(1986). RN [5] RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 103-117. RX MEDLINE=96085023; PubMed=7477400; RA Ghosh P., Amaya M., Mellins E., Wiley D.C.; RT "The structure of an intermediate in class II MHC maturation: CLIP RT bound to HLA-DR3."; RL Nature 378:457-462(1995). RN [6] RP STRUCTURE BY NMR OF 134-208. RX MEDLINE=99059718; PubMed=9843486; RA Jasanoff A., Wagner G., Wiley D.C.; RT "Structure of a trimeric domain of the MHC class II-associated RT chaperonin and targeting protein Ii."; RL EMBO J. 17:6812-6818(1998). CC -!- FUNCTION: PLAYS A CRITICAL ROLE IN MHC CLASS II ANTIGEN PROCESSING CC BY STABILIZING PEPTIDE-FREE CLASS II ALPHA/BETA HETERODIMERS IN A CC COMPLEX SOON AFTER THEIR SYNTHESIS AND DIRECTING TRANSPORT OF THE CC COMPLEX FROM THE ENDOPLASMIC RETICULUM TO COMPARTMENTS WHERE CC PEPTIDE LOADING OF CLASS II TAKES PLACE. CC -!- SUBUNIT: NONAMER COMPOSED OF THREE ALPHA/BETA/GAMMA HETEROTRIMERS. CC -!- SUBCELLULAR LOCATION: Type II membrane protein (Potential). CC -!- SIMILARITY: CONTAINS 1 THYROGLOBULIN TYPE-I DOMAIN. CC -!- DATABASE: NAME=PROW; NOTE=CD guide CD74 entry; CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd74.htm". CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X03339; CAA27046.1; -. DR EMBL; X03340; CAA27047.1; -. DR EMBL; K01144; AAA36304.1; -. DR EMBL; X00497; CAA25192.1; -. DR EMBL; X00497; CAA25193.1; -. DR PIR; A30060; HLHUG. DR PDB; 1A6A; 27-MAY-98. DR PDB; 1IIE; 15-FEB-99. DR MIM; 142790; -. DR InterPro; IPR000716; Thyroglobulin_1. DR Pfam; PF00086; thyroglobulin_1; 1. DR SMART; SM00211; TY; 1. DR PROSITE; PS00484; THYROGLOBULIN_1; 1. KW Glycoprotein; MHC II; Proteoglycan; Transmembrane; KW Alternative splicing; Signal-anchor; 3D-structure. FT DOMAIN 1 46 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 47 72 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN) FT (POTENTIAL). FT DOMAIN 73 296 EXTRACELLULAR (POTENTIAL). FT DOMAIN 103 117 CLIP. FT CARBOHYD 130 130 N-LINKED (GLCNAC...). FT CARBOHYD 136 136 N-LINKED (GLCNAC...). FT CARBOHYD 282 282 O-LINKED (GLYCOSAMINOGLYCAN). FT DOMAIN 228 271 THYROGLOBULIN TYPE I. FT VARSPLIC 209 272 MISSING (IN SHORT ISOFORM). FT CONFLICT 167 167 T -> R (IN REF. 2 AND 3). SQ SEQUENCE 296 AA; 33460 MW; C9A301208D5FB918 CRC64; MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLTHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM //