ID HG2A_HUMAN STANDARD; PRT; 296 AA. AC P04233; Q29832; DT 20-MAR-1987 (Rel. 04, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 15-JUL-1999 (Rel. 38, Last annotation update) DE HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, GAMMA CHAIN (HLA-DR ANTIGENS DE ASSOCIATED INVARIANT CHAIN) (P33) (CD74 ANTIGEN). GN CD74 OR DHLAG. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 86093681. RA KUDO J., CHAO L.Y., NARNI F., SAUNDERS G.F.; RT "Structure of the human gene encoding the invariant gamma-chain of RT class II histocompatibility antigens."; RL Nucleic Acids Res. 13:8827-8841(1985). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 84207945. RA STRUBIN M., MACH B., LONG E.O.; RT "The complete sequence of the mRNA for the HLA-DR-associated RT invariant chain reveals a polypeptide with an unusual transmembrane RT polarity."; RL EMBO J. 3:869-872(1984). RN [3] RP SEQUENCE OF 27-96 FROM N.A. RX MEDLINE; 84170234. RA CLAESSON L., LARHAMMAR D., RASK L., PETERSON P.A.; RT "cDNA clone for the human invariant gamma chain of class II RT histocompatibility antigens and its implications for the protein RT structure."; RL Proc. Natl. Acad. Sci. U.S.A. 80:7395-7399(1983). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE; 86233451. RA O'SULLIVAN D.M., LARHAMMAR D., WILSON M.C., PETERSON P.A., RA QUARANTA V.; RT "Structure of the human Ia-associated invariant (gamma)-chain gene: RT identification of 5' sequences shared with major histocompatibility RT complex class II genes."; RL Proc. Natl. Acad. Sci. U.S.A. 83:4484-4488(1986). RN [5] RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 103-117. RX MEDLINE; 96085023. RA GHOSH P., AMAYA M., MELLINS E., WILEY D.C.; RT "The structure of an intermediate in class II MHC maturation: CLIP RT bound to HLA-DR3."; RL Nature 378:457-462(1995). RN [6] RP STRUCTURE BY NMR OF 134-208. RX MEDLINE; 99059718. RA JASANOFF A., WAGNER G., WILEY D.C.; RT "Structure of a trimeric domain of the MHC class II-associated RT chaperonin and targeting protein Ii."; RL EMBO J. 17:6812-6818(1998). CC -!- FUNCTION: PLAYS A CRITICAL ROLE IN MHC CLASS II ANTIGEN PROCESSING CC BY STABILIZING PEPTIDE-FREE CLASS II ALPHA/BETA HETERODIMERS IN A CC COMPLEX SOON AFTER THEIR SYNTHESIS AND DIRECTING TRANSPORT OF THE CC COMPLEX FROM THE ENDOPLASMIC RETICULUM TO COMPARTMENTS WHERE CC PEPTIDE LOADING OF CLASS II TAKES PLACE. CC -!- SUBUNIT: NONAMER COMPOSED OF THREE ALPHA/BETA/GAMMA HETEROTRIMERS. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN (POTENTIAL). CC -!- SIMILARITY: CONTAINS 1 THYROGLOBULIN TYPE-I DOMAIN. CC -!- DATABASE: NAME=PROW; NOTE=CD guide CD74 entry; CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd74.htm". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X03339; CAA27046.1; -. DR EMBL; X03340; CAA27047.1; -. DR EMBL; K01144; AAA36304.1; -. DR EMBL; X00497; CAA25192.1; -. DR EMBL; X00497; CAA25193.1; -. DR PIR; A30060; HLHUG. DR PDB; 1A6A; 27-MAY-98. DR PDB; 1IIE; 15-FEB-99. DR MIM; 142790; -. DR PFAM; PF00086; thyroglobulin_1; 1. DR PROSITE; PS00484; THYROGLOBULIN_1; 1. KW Glycoprotein; MHC; Proteoglycan; Transmembrane; Alternative splicing; KW Signal-anchor; 3D-structure. FT DOMAIN 1 46 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 47 72 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN). FT DOMAIN 73 296 EXTRACELLULAR (POTENTIAL). FT DOMAIN 103 117 CLIP. FT CARBOHYD 130 130 FT CARBOHYD 136 136 FT CARBOHYD 282 282 GLYCOSAMINOGLYCAN. FT VARSPLIC 209 272 MISSING (IN SMALL ISOFORM). FT DOMAIN 228 271 THYROGLOBULIN TYPE I. FT CONFLICT 167 167 T -> R (IN REF. 2 AND 3). SQ SEQUENCE 296 AA; 33460 MW; 4E8A044A CRC32; MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLTHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM //