ID HG2A_HUMAN STANDARD; PRT; 296 AA. AC P04233; DT 20-MAR-1987 (REL. 04, CREATED) DT 01-JUL-1993 (REL. 26, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, GAMMA CHAIN (HLA-DR ANTIGENS DE ASSOCIATED INVARIANT CHAIN) (P33) (CD74 ANTIGEN). GN CD74 OR DHLAG. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 86093681. RA KUDO J., CHAO L.Y., NARNI F., SAUNDERS G.F.; RL NUCLEIC ACIDS RES. 13:8827-8841(1985). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 84207945. RA STRUBIN M., MACH B., LONG E.O.; RL EMBO J. 3:869-872(1984). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 86233451. RA O'SULLIVAN D.M., LARHAMMAR D., WILSON M.C., PETERSON P.A., RA QUARANTA V.; RL PROC. NATL. ACAD. SCI. U.S.A. 83:4484-4488(1986). CC -!- FUNCTION: IT IS THOUGHT THAT THE GAMMA-CHAIN PROTEIN IS INVOLVED CC IN THE ASSEMBLY OF CLASS II HLA-DR HETERODIMERS AND THEIR CC TRANSPORT TO THE SURFACE. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN (POTENTIAL). CC -!- DOMAIN: CONTAINS A THYROGLOBULIN TYPE I DOMAIN WHICH MAY HAVE A CC ROLE IN INTRACELLULAR PROTEIN TRANSPORT AND SECRETION. CC -!- DATABASE: NAME=PROW; NOTE=CD guide CD74 entry; CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd74.htm". CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X03339; G34647; -. DR EMBL; X03340; E70119; -. DR EMBL; X00497; G32131; -. DR PIR; A30060; HLHUG. DR MIM; 142790; -. DR PROSITE; PS00484; THYROGLOBULIN_1; 1. KW GLYCOPROTEIN; MHC; PROTEOGLYCAN; TRANSMEMBRANE; ALTERNATIVE SPLICING; KW SIGNAL-ANCHOR. FT DOMAIN 1 46 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 47 72 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN). FT DOMAIN 73 296 EXTRACELLULAR (POTENTIAL). FT CARBOHYD 130 130 FT CARBOHYD 136 136 FT CARBOHYD 282 282 GLYCOSAMINOGLYCAN. FT VARSPLIC 209 272 MISSING (IN SPLICED VARIANT). FT DOMAIN 228 271 THYROGLOBULIN TYPE I. FT CONFLICT 167 167 T -> R (IN REF. 2). SQ SEQUENCE 296 AA; 33460 MW; 4E8A044A CRC32; MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLTHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM //