ID HG2A_HUMAN STANDARD; PRT; 296 AA. AC P04233; DT 20-MAR-1987 (REL. 04, CREATED) DT 01-JUL-1993 (REL. 26, LAST SEQUENCE UPDATE) DT 01-OCT-1993 (REL. 27, LAST ANNOTATION UPDATE) DE HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, GAMMA CHAIN PRECURSOR (HLA-DR DE ANTIGENS ASSOCIATED INVARIANT CHAIN) (P33) (CD74). GN DHLAG. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RM 86093681 RA KUDO J., CHAO L.Y., NARNI F., SAUNDERS G.F.; RL NUCLEIC ACIDS RES. 13:8827-8841(1985). RN [2] RP SEQUENCE FROM N.A. RM 84207945 RA STRUBIN M., MACH B., LONG E.O.; RL EMBO J. 3:869-872(1984). RN [3] RP SEQUENCE FROM N.A. RM 86233451 RA O'SULLIVAN D.M., LARHAMMAR D., WILSON M.C., PETERSON P.A., RA QUARANTA V.; RL PROC. NATL. ACAD. SCI. U.S.A. 83:4484-4488(1986). CC -!- FUNCTION: IT IS THOUGHT THAT THE GAMMA-CHAIN PROTEIN IS INVOLVED CC IN THE ASSEMBLY OF CLASS II HLA-DR HETERODIMERS AND THEIR CC TRANSPORT TO THE SURFACE. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X03339; HSMHCGE1. DR EMBL; X03340; HSMHCGE2. DR EMBL; X00497; HSHL05. DR PIR; A30060; HLHUG. DR MIM; 142790; TENTH EDITION. DR PROSITE; PS00484; THYROGLOBULIN_1. KW GLYCOPROTEIN; MHC; PROTEOGLYCAN; TRANSMEMBRANE; ALTERNATIVE SPLICING. FT DOMAIN 1 46 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 46 72 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN). FT DOMAIN 73 296 EXTRACELLULAR (POTENTIAL). FT CARBOHYD 130 130 FT CARBOHYD 136 136 FT CARBOHYD 282 282 GLYCOSAMINOGLYCAN. FT VARSPLIC 209 272 MISSING (IN SPLICED VARIANT). FT DOMAIN 228 271 THYROGLOBULIN TYPE I. FT CONFLICT 167 167 T -> R (IN REF. 2). SQ SEQUENCE 296 AA; 33460 MW; 479425 CN; MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLTHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM //