ID VGLM_RVFV Reviewed; 1206 AA. AC P03518; Q86494; Q86495; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 2. DT 28-NOV-2006, entry version 39. DE Envelope glycoprotein precursor (GP) (M polyprotein) [Contains: Non- DE structural protein NSm; Glycoprotein G1; Glycoprotein G2]. GN Name=M; OS Rift valley fever virus (RVFV). OC Viruses; ssRNA negative-strand viruses; Bunyaviridae; Phlebovirus. OX NCBI_TaxID=11588; OH NCBI_TaxID=7158; Aedes. OH NCBI_TaxID=9913; Bos taurus (Bovine). OH NCBI_TaxID=297284; Bos taurus X Bison bison (beefalo). OH NCBI_TaxID=9837; Camelus bactrianus (Bactrian camel). OH NCBI_TaxID=9925; Capra hircus (Goat). OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9940; Ovis aries (Sheep). OH NCBI_TaxID=29031; Phlebotomus papatasi. RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX MEDLINE=86045943; PubMed=2998042; RA Collett M.S., Purchio A.F., Keegan K., Frazier S., Hays W., RA Anderson D.K., Parker M.D., Schmaljohn C.S., Schmidt J., RA Dalrymple J.M.; RT "Complete nucleotide sequence of the M RNA segment of Rift Valley RT fever virus."; RL Virology 144:228-245(1985). CC -!- FUNCTION: Glycoprotein G1 and Glycoprotein G2 interact with each CC other and are present at the surface of the virion. They are able CC to attach the virion to a cell receptor and to promote fusion of CC membranes after endocytosis of the virion (By similarity). CC -!- SUBUNIT: G1 and G2 interacts with each other (By similarity). CC -!- SUBCELLULAR LOCATION: Virion; virion membrane. Glycoprotein G1: CC Golgi apparatus; Golgi apparatus membrane; single-pass membrane CC protein. Glycoprotein G2: Golgi apparatus; Golgi apparatus CC membrane; single-pass membrane protein. Interaction between G1 and CC G2 is essential for proper targeting to the Golgi, where virion CC budding occurs (By similarity). CC -!- PTM: Specific enzymatic cleavages in vivo yield mature proteins CC including nonstructural protein NSm, glycoprotein G1, and CC glycoprotein G2. CC -!- SIMILARITY: Belongs to the phleboviruses M polyprotein family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M11157; AAA47450.1; -; Genomic_RNA. DR PIR; A04110; VGVURV. DR InterPro; IPR010826; Phlebovirus_G1. DR InterPro; IPR009878; Phlebovirus_G2. DR InterPro; IPR009879; Phlebovirus_NSM. DR Pfam; PF07243; Phlebovirus_G1; 1. DR Pfam; PF07245; Phlebovirus_G2; 1. DR Pfam; PF07246; Phlebovirus_NSM; 1. KW Glycoprotein; Golgi apparatus; Membrane; Signal; Transmembrane; KW Virion protein. FT SIGNAL 1 16 Potential. FT CHAIN 17 1206 Envelope glycoprotein. FT /FTId=PRO_0000247009. FT CHAIN 17 153 Non-structural protein NSm. FT /FTId=PRO_0000036847. FT CHAIN 154 690 Glycoprotein G1 (Potential). FT /FTId=PRO_0000036848. FT CHAIN 691 1206 Glycoprotein G2 (Potential). FT /FTId=PRO_0000036849. FT TRANSMEM 583 603 Potential. FT SITE 690 691 Cleavage (by host signal peptidase) (By FT similarity). FT CARBOHYD 88 88 N-linked (GlcNAc...) (Potential). FT CARBOHYD 438 438 N-linked (GlcNAc...) (Potential). FT CARBOHYD 794 794 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1035 1035 N-linked (GlcNAc...) (Potential). FT CARBOHYD 1077 1077 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 1206 AA; 132053 MW; D2E8017179285924 CRC64; MYVLLTILIS VLVCEAVIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE EMPEELSCSI SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI SLIKGPPHKK RVGIVRCERR RDAKQIGRET MAGIAMTVLP ALAVFALAPV VFAEDPHLRN RPGKGHNYID GMTQEDATCK PVTYAGACSS FDVLLEKGKF PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LQSAHGNPCM KEKLVMKTHC PNDYQSAHYL NNDGKMASVK CPPKYGLTED CNFCRQMTGA SLKKGSYPLQ DLFCQSSEDD GSKLKTKMKG VCEVGVQAHK KCDGQLSTAH EVVPFAVFKN SKKVYLDKLD LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS QCPKIGGHGS KKCTGDAAFC SAYECTAQYA NAYCSHANGS GIVQIQVSGV WKKPLCVGYE RVVVKRELSA KPIQRVEPCT TCITKCEPHG LVVRSTGFKI SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH MAHDDQSVSS KIVAHCPPQD PCLVHGCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL AVLYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA HNINQVNREI GWMEGGQLVL GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR ITTCSTEGVN TKCRLSGTAL IRAGSVGAEA CLMLKGVKED QTKFLKIKTV SSELSCREGQ SYWTGSISPK CLSSRRCHLV GECHVNRCLS WRDNETSAEF SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ SVRKEALRVF NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS NSFSFIESPS KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA PNLISYKPMI DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ AFSKGSVQAD LTLMFDNFEV DFVGAAVSCD AAFLNLTGCY SCNAGARVCL SITSTGTGSL SAHNKDGSLH IVLPSENGTK DQCQILHFTV PEVEEEFMYS CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW NFFDWFSGLM SWFGGPLKLY SSFACMLHYQ LGSFSSLYIL EEQASLKCGL LPLRRPHRSV RVKVIC //