ID NRAM_IADGE STANDARD; PRT; 96 AA. AC P03480; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE) DE NEURAMINIDASE (EC 3.2.1.18) (FRAGMENT). GN NA. OS INFLUENZA A VIRUS (STRAIN A/DUCK/GERMANY/49). OC VIRIDAE; SS-RNA ENVELOPED VIRUSES; NEGATIVE-STRAND; ORTHOMYXOVIRIDAE. RN [1] RP SEQUENCE FROM N.A. RM 83023028 RA BLOK J., AIR G.M.; RL BIOCHEMISTRY 21:4001-4007(1982). CC -!- FUNCTION: PREVENT SELF-AGGREGATION BY REMOVING THE CARBOHYDRATE CC FROM THE VIRAL ENVELOPE. FACILITATE THE MOBILITY OF THE VIRUS TO CC AND FROM THE SITE OF INFECTION. CC -!- CATALYTIC ACTIVITY: CLEAVE THE TERMINAL SIALIC ACID (N-ACETYL CC NEURAMINIC ACID) FROM CARBOHYDRATE CHAINS IN GLYCOPROTEINS. CC -!- SUBUNIT: HOMOTETRAMER. CC -!- SUBCELLULAR LOCATION: VIRAL MEMBRANE. FORMS A MUSHROOM-SHAPED CC SPIKE ON THE SURFACE OF THE VIRION. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; A00892; A00892. KW HYDROLASE; GLYCOSIDASE; GLYCOPROTEIN; TRANSMEMBRANE. FT TRANSMEM 7 35 ANCHOR. FT DOMAIN 36 89 HYPERVARIABLE STALK REGION. FT DOMAIN 90 >96 HEAD OF NEURAMINIDASE. FT CARBOHYD 32 32 POTENTIAL. FT CARBOHYD 47 47 POTENTIAL. FT CARBOHYD 56 56 POTENTIAL. FT CARBOHYD 57 57 POTENTIAL. FT CARBOHYD 67 67 POTENTIAL. FT CARBOHYD 68 68 POTENTIAL. FT CARBOHYD 87 87 POTENTIAL. FT NON_TER 96 96 SQ SEQUENCE 96 AA; 10472 MW; 53122 CN; MNPNQKLFAL SGVAIALSVM NLLIGISNVG LNVSLHLKEK GTKQEENLTC TTITQNNTTV VENTYVNNTT IITKEPDLKA PSYLLLNHSL CSVEGW //