ID NRAM_IADGE STANDARD; PRT; 96 AA. AC P03480; DT 21-JUL-1986 (Rel. 01, Created) DT 21-JUL-1986 (Rel. 01, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Neuraminidase (EC 3.2.1.18) (Fragment). GN NA. OS Influenza A virus (strain A/Duck/Germany/49). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenza A viruses; Influenzavirus A. OX NCBI_TaxID=11356; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=83023028; PubMed=6896994; RA Blok J., Air G.M.; RT "Variation in the membrane-insertion and 'stalk' sequences in eight RT subtypes of influenza type A virus neuraminidase."; RL Biochemistry 21:4001-4007(1982). CC -!- FUNCTION: Removes the terminal sialic acid from carbohydrate side CC chains of the host cell surface proteins and from the viral CC envelope. Such a reaction prevents self-aggregation and facilitate CC the mobility of the virus to and from the site of infection. CC -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, CC alpha-(2->8)-glycosidic linkages of terminal sialic residues in CC oligosaccharides, glycoproteins, glycolipids, colominic acid and CC synthetic substrates. CC -!- SUBUNIT: Homotetramer. CC -!- SUBCELLULAR LOCATION: Viral membrane. Forms a mushroom-shaped CC spike on the surface of the virion. CC -!- SIMILARITY: Belongs to family 34 of glycosyl hydrolases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J02099; AAA43391.1; -. DR InterPro; IPR001860; Glyco_hydro_34. DR Pfam; PF00064; neur; 1. KW Hydrolase; Glycosidase; Glycoprotein; Transmembrane. FT TRANSMEM 7 35 Anchor. FT DOMAIN 36 89 HYPERVARIABLE STALK REGION. FT DOMAIN 90 >96 HEAD OF NEURAMINIDASE. FT CARBOHYD 47 47 N-linked (GlcNAc...) (Potential). FT CARBOHYD 56 56 N-linked (GlcNAc...) (Potential). FT CARBOHYD 57 57 N-linked (GlcNAc...) (Potential). FT CARBOHYD 67 67 N-linked (GlcNAc...) (Potential). FT CARBOHYD 68 68 N-linked (GlcNAc...) (Potential). FT CARBOHYD 87 87 N-linked (GlcNAc...) (Potential). FT NON_TER 96 96 SQ SEQUENCE 96 AA; 10472 MW; F6382279F093C552 CRC64; MNPNQKLFAL SGVAIALSVM NLLIGISNVG LNVSLHLKEK GTKQEENLTC TTITQNNTTV VENTYVNNTT IITKEPDLKA PSYLLLNHSL CSVEGW //