ID TCR2$ECOLI STANDARD; PRT; 396 AA. AC P02981; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 01-FEB-1991 (REL. 17, LAST ANNOTATION UPDATE) DE TETRACYCLINE RESISTANCE PROTEIN (GENE NAME: TETA). OS ESCHERICHIA COLI. OG PLASMID PBR322. OC PROKARYOTA; GRACILICUTES; SCOTOBACTERIA; FACULTATIVELY ANAEROBIC RODS; OC ENTEROBACTERIACEAE. RN [1] (SEQUENCE FROM N.A.) RA SUTCLIFFE J.G.; RL COLD SPRING HARB. SYMP. QUANT. BIOL. 43:77-90(1979). RN [2] (REVISION AND IDENTIFICATION OF THE PROTEIN) RA LIVNEH Z.; RL PROC. NATL. ACAD. SCI. U.S.A. 80:237-241(1983). RN [3] (REVISION AND IDENTIFICATION OF THE PROTEIN) RA PEDEN K.W.C.; RL GENE 22:277-280(1983). CC -!- FUNCTION: RESISTANCE TO TETRACYCLINE BY AN ACTIVE TETRACYCLINE CC EFFLUX. THIS IS AN ENERGY-DEPENDENT PROCESS THAT DECREASES THE CC ACCUMULATION OF THE ANTIBIOTIC IN WHOLE CELLS. THIS PROTEIN CC FUNCTIONS AS A METAL-TETRACYCLINE/H+ ANTIPORTER. CC -!- THERE ARE PROBABLY 12 TRANSMEMBRANE REGIONS. CC -!- SUBCELLULAR LOCATION: MEMBRANE-BOUND. CC -!- SIMILARITY: STRONG TO OTHER ENTEROBACTERIAE TETA, AND TO TET CC PROTEINS OF OTHER COCCI PLASMIDS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; V01119; PBR322. DR PIR; A03508; YTEC32. KW TRANSMEMBRANE; ANTIBIOTIC RESISTANCE; TRANSPORT; SYMPORT; KW PLASMID. SQ SEQUENCE 396 AA; 41510 MW; 768857 CN; MKSNNALIVI LGTVTLDAVG IGLVMPVLPG LLRDIVHSDS IASHYGVLLA LYALMQFLCA PVLGALSDRF GRRPVLLASL LGATIDYAIM ATTPVLWILY AGRIVAGITG ATGAVAGAYI ADITDGEDRA RHFGLMSACF GVGMVAGPVA GGLLGAISLH APFLAAAVLN GLNLLLGCFL MQESHKGERR PMPLRAFNPV SSFRWARGMT IVAALMTVFF IMQLVGQVPA ALWVIFGEDR FRWSATMIGL SLAVFGILHA LAQAFVTGPA TKRFGEKQAI IAGMAADALG YVLLAFATRG WMAFPIMILL ASGGIGMPAL QAMLSRQVDD DHQGQLQGSL AALTSLTSIT GPLIVTAIYA ASASTWNGLA WIVGAALYLV CLPALRRGAW SRATST //