ID TCR2_ECOLI STANDARD; PRT; 396 AA. AC P02981; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE) DE TETRACYCLINE RESISTANCE PROTEIN. GN TETA. OS ESCHERICHIA COLI. OG PLASMID PBR322. OC PROKARYOTA; GRACILICUTES; SCOTOBACTERIA; FACULTATIVELY ANAEROBIC RODS; OC ENTEROBACTERIACEAE. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 80002802. RA SUTCLIFFE J.G.; RL COLD SPRING HARB. SYMP. QUANT. BIOL. 43:77-90(1979). RN [2] RP REVISIONS, AND IDENTIFICATION OF PROTEIN. RX MEDLINE; 83117828. RA LIVNEH Z.; RL PROC. NATL. ACAD. SCI. U.S.A. 80:237-241(1983). RN [3] RP REVISIONS, AND IDENTIFICATION OF PROTEIN. RX MEDLINE; 83263146. RA PEDEN K.W.C.; RL GENE 22:277-280(1983). CC -!- FUNCTION: RESISTANCE TO TETRACYCLINE BY AN ACTIVE TETRACYCLINE CC EFFLUX. THIS IS AN ENERGY-DEPENDENT PROCESS THAT DECREASES THE CC ACCUMULATION OF THE ANTIBIOTIC IN WHOLE CELLS. THIS PROTEIN CC FUNCTIONS AS A METAL-TETRACYCLINE/H+ ANTIPORTER. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE. CC -!- SIMILARITY: BELONGS TO THE MAJOR FACILITATOR FAMILY (ALSO KNOWN CC AS THE DRUG RESISTANCE TRANSLOCASE FAMILY). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; V01119; V01119. DR PIR; A03508; YTEC32. DR PROSITE; PS00216; SUGAR_TRANSPORT_1. KW ANTIBIOTIC RESISTANCE; TRANSMEMBRANE; INNER MEMBRANE; TRANSPORT; KW SYMPORT; PLASMID. FT TRANSMEM 8 28 POTENTIAL. FT TRANSMEM 44 64 POTENTIAL. FT TRANSMEM 76 96 POTENTIAL. FT TRANSMEM 104 124 POTENTIAL. FT TRANSMEM 133 153 POTENTIAL. FT TRANSMEM 161 181 POTENTIAL. FT TRANSMEM 216 236 POTENTIAL. FT TRANSMEM 246 267 POTENTIAL. FT TRANSMEM 279 299 POTENTIAL. FT TRANSMEM 300 320 POTENTIAL. FT TRANSMEM 338 358 POTENTIAL. FT TRANSMEM 365 385 POTENTIAL. SQ SEQUENCE 396 AA; 41510 MW; 768857 CN; MKSNNALIVI LGTVTLDAVG IGLVMPVLPG LLRDIVHSDS IASHYGVLLA LYALMQFLCA PVLGALSDRF GRRPVLLASL LGATIDYAIM ATTPVLWILY AGRIVAGITG ATGAVAGAYI ADITDGEDRA RHFGLMSACF GVGMVAGPVA GGLLGAISLH APFLAAAVLN GLNLLLGCFL MQESHKGERR PMPLRAFNPV SSFRWARGMT IVAALMTVFF IMQLVGQVPA ALWVIFGEDR FRWSATMIGL SLAVFGILHA LAQAFVTGPA TKRFGEKQAI IAGMAADALG YVLLAFATRG WMAFPIMILL ASGGIGMPAL QAMLSRQVDD DHQGQLQGSL AALTSLTSIT GPLIVTAIYA ASASTWNGLA WIVGAALYLV CLPALRRGAW SRATST //