ID TCR2_ECOLI STANDARD; PRT; 396 AA. AC P02981; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE) DE TETRACYCLINE RESISTANCE PROTEIN. GN TETA. OS ESCHERICHIA COLI. OG PLASMID PBR322. OC PROKARYOTA; GRACILICUTES; SCOTOBACTERIA; FACULTATIVELY ANAEROBIC RODS; OC ENTEROBACTERIACEAE. RN [1] RP SEQUENCE FROM N.A. RM 80002802 RA SUTCLIFFE J.G.; RL COLD SPRING HARB. SYMP. QUANT. BIOL. 43:77-90(1979). RN [2] RP REVISIONS, AND IDENTIFICATION OF PROTEIN. RM 83117828 RA LIVNEH Z.; RL PROC. NATL. ACAD. SCI. U.S.A. 80:237-241(1983). RN [3] RP REVISIONS, AND IDENTIFICATION OF PROTEIN. RM 83263146 RA PEDEN K.W.C.; RL GENE 22:277-280(1983). CC -!- FUNCTION: RESISTANCE TO TETRACYCLINE BY AN ACTIVE TETRACYCLINE CC EFFLUX. THIS IS AN ENERGY-DEPENDENT PROCESS THAT DECREASES THE CC ACCUMULATION OF THE ANTIBIOTIC IN WHOLE CELLS. THIS PROTEIN CC FUNCTIONS AS A METAL-TETRACYCLINE/H+ ANTIPORTER. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. INNER MEMBRANE. CC CONTAINS 12 POTENTIAL TRANSMEMBRANE DOMAINS. CC -!- SIMILARITY: BELONGS TO THE MAJOR FACILITATOR FAMILY (ALSO KNOWN CC AS THE DRUG RESISTANCE TRANSLOCASE FAMILY). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; V01119; PBR322. DR PIR; A03508; YTEC32. KW ANTIBIOTIC RESISTANCE; TRANSMEMBRANE; INNER MEMBRANE; TRANSPORT; KW SYMPORT; PLASMID. SQ SEQUENCE 396 AA; 41510 MW; 768857 CN; MKSNNALIVI LGTVTLDAVG IGLVMPVLPG LLRDIVHSDS IASHYGVLLA LYALMQFLCA PVLGALSDRF GRRPVLLASL LGATIDYAIM ATTPVLWILY AGRIVAGITG ATGAVAGAYI ADITDGEDRA RHFGLMSACF GVGMVAGPVA GGLLGAISLH APFLAAAVLN GLNLLLGCFL MQESHKGERR PMPLRAFNPV SSFRWARGMT IVAALMTVFF IMQLVGQVPA ALWVIFGEDR FRWSATMIGL SLAVFGILHA LAQAFVTGPA TKRFGEKQAI IAGMAADALG YVLLAFATRG WMAFPIMILL ASGGIGMPAL QAMLSRQVDD DHQGQLQGSL AALTSLTSIT GPLIVTAIYA ASASTWNGLA WIVGAALYLV CLPALRRGAW SRATST //