ID VTDB_HUMAN STANDARD; PRT; 474 AA. AC P02774; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE) DE VITAMIN D-BINDING PROTEIN PRECURSOR (DBP) (GROUP-SPECIFIC COMPONENT) DE (GC-GLOBULIN) (VDB). GN GC. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 86068030. RA YANG F., BRUNE J.L., NAYLOR S.L., CUPPLES R.L., NABERHAUS K.H., RA BOWMAN B.H.; RL PROC. NATL. ACAD. SCI. U.S.A. 82:7994-7998(1985). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 86086396. RA COOKE N.E., DAVID E.V.; RL J. CLIN. INVEST. 76:2420-2424(1985). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 94092730. RA BRAUN A., KOFLER A., MORAWIETZ S., CLEVE H.; RL BIOCHIM. BIOPHYS. ACTA 1216:385-394(1993). RN [4] RP SEQUENCE OF 17-474. RX MEDLINE; 86216223. RA SCHOENTGEN F., METZ-BOUTIGUE M.-H., JOLLES J., CONSTANS J., RA JOLLES P.; RL BIOCHIM. BIOPHYS. ACTA 871:189-198(1986). RN [5] RP SEQUENCE OF 17-31 AND 431-441. RX MEDLINE; 79145448. RA SVASTI J., KUROSKY A., BENNETT A., BOWMAN B.H.; RL BIOCHEMISTRY 18:1611-1617(1979). RN [6] RP SEQUENCE OF 1-19 FROM N.A. RX MEDLINE; 88005794. RA YANG F., NABERHAUS K.H., ADRIAN G.S., GARDELLA J.M., BRISSENDEN J.E., RA BOWMAN B.H.; RL GENE 54:285-290(1987). RN [7] RP VARIANTS GC2; GC1F AND GC1S. RX MEDLINE; 92316509. RA BRAUN A., BICHLMAIER R., CLEVE H.; RL HUM. GENET. 89:401-406(1992). CC -!- FUNCTION: MULTIFUNCTIONAL PROTEIN FOUND IN PLASMA, ASCITIC FLUID, CC CEREBROSPINAL FLUID, AND URINE AND ON THE SURFACE OF MANY CELL CC TYPES. IN PLASMA, IT CARRIES THE VITAMIN D STEROLS AND PREVENTS CC POLYMERIZATION OF ACTIN BY BINDING ITS MONOMERS. DBP ASSOCIATES CC WITH MEMBRANE-BOUND IMMUNOGLOBULIN ON THE SURFACE OF B-LYMPHOCYTES CC AND WITH IGG FC RECEPTOR ON THE MEMBRANES OF T-LYMPHOCYTES. CC -!- SUBCELLULAR LOCATION: EXTRACELLULAR. CC -!- DOMAIN: COMPOSED OF THREE HOMOLOGOUS DOMAINS. CC -!- POLYMORPHISM: OVER 80 VARIANTS OF HUMAN DBP HAVE BEEN IDENTIFIED. CC THE THREE MOST COMMON ALLELES ARE CALLED GC1F, GC1S, AND GC2. THE CC SEQUENCE SHOWN IS THAT OF THE GC2 ALLELE. CC -!- SIMILARITY: BELONGS TO THE ALB/AFP/VDB FAMILY OF PROTEINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L10641; G639896; -. DR EMBL; M11321; G183006; -. DR EMBL; X03178; G31676; -. DR EMBL; M12654; G181482; -. DR EMBL; S67480; G455970; -. DR EMBL; S67474; G455970; JOINED. DR EMBL; S67476; G455970; JOINED. DR EMBL; S67478; G455970; JOINED. DR EMBL; S67479; G455970; JOINED. DR EMBL; S67526; G455970; JOINED. DR EMBL; M17156; G463096; -. DR PIR; A03237; VYHUD. DR PIR; A24066; A24066. DR PIR; A29096; A29096. DR SWISS-2DPAGE; P02774; HUMAN. DR MIM; 139200; -. DR PROSITE; PS00212; ALBUMIN; 1. KW ALBUMIN; GLYCOPROTEIN; VITAMIN D; TRANSPORT; PLASMA; ACTIN-BINDING; KW REPEAT; POLYMORPHISM; SIGNAL. FT SIGNAL 1 16 FT CHAIN 17 474 VITAMIN D-BINDING PROTEIN. FT REPEAT 22 199 1. FT REPEAT 218 385 2. FT REPEAT 404 474 3. FT DISULFID 29 75 BY SIMILARITY. FT DISULFID 74 83 BY SIMILARITY. FT DISULFID 96 112 BY SIMILARITY. FT DISULFID 111 122 BY SIMILARITY. FT DISULFID 145 190 BY SIMILARITY. FT DISULFID 189 198 BY SIMILARITY. FT DISULFID 220 266 BY SIMILARITY. FT DISULFID 265 273 BY SIMILARITY. FT DISULFID 286 300 BY SIMILARITY. FT DISULFID 299 311 BY SIMILARITY. FT DISULFID 335 376 BY SIMILARITY. FT DISULFID 375 384 BY SIMILARITY. FT DISULFID 407 453 BY SIMILARITY. FT DISULFID 452 462 BY SIMILARITY. FT CARBOHYD 288 288 POTENTIAL. FT VARIANT 432 432 D -> E (IN GC1S ALLELE). FT VARIANT 436 436 K -> T (IN GC1F AND GC1S ALLELES). FT CONFLICT 168 168 G -> E (IN REF. 2). FT CONFLICT 327 327 E -> R (IN REF. 2). SQ SEQUENCE 474 AA; 52963 MW; E6EC123D CRC32; MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK KLAERLKAKL PDATPKELAK LVNKRSDFAS NCCSINSPPL YCDSEIDAEL KNIL //