ID VTDB_HUMAN STANDARD; PRT; 474 AA. AC P02774; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE) DE VITAMIN D-BINDING PROTEIN PRECURSOR (DBP) (GROUP-SPECIFIC COMPONENT) DE (GC-GLOBULIN). GN GC. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RM 86068030 RA YANG F., BRUNE J.L., NAYLOR S.L., CUPPLES R.L., NABERHAUS K.H., RA BOWMAN B.H.; RL PROC. NATL. ACAD. SCI. U.S.A. 82:7994-7998(1985). RN [2] RP SEQUENCE FROM N.A. RM 86086396 RA COOKE N.E., DAVID E.V.; RL J. CLIN. INVEST. 76:2420-2424(1985). RN [3] RP SEQUENCE OF 17-474. RM 86216223 RA SCHOENTGEN F., METZ-BOUTIGUE M.-H., JOLLES J., CONSTANS J., RA JOLLES P.; RL BIOCHIM. BIOPHYS. ACTA 871:189-198(1986). RN [4] RP SEQUENCE OF 17-31 AND 431-441. RM 79145448 RA SVASTI J., KUROSKY A., BENNETT A., BOWMAN B.H.; RL BIOCHEMISTRY 18:1611-1617(1979). RN [5] RP SEQUENCE OF 1-19 FROM N.A. RM 88005794 RA YANG F., NABERHAUS K.H., ADRIAN G.S., GARDELLA J.M., BRISSENDEN J.E., RA BOWMAN B.H.; RL GENE 54:285-290(1987). RN [6] RP VARIANTS GC2; GC1F AND GC1S. RM 92316509 RA BRAUN A., BICHLMAIER R., CLEVE H.; RL HUM. GENET. 89:401-406(1992). CC -!- FUNCTION: DBP IS A MULTIFUNCTIONAL PROTEIN FOUND IN PLASMA, CC ASCITIC FLUID, CEREBROSPINAL FLUID, AND URINE AND ON THE SURFACE CC OF MANY CELL TYPES. IN PLASMA, IT CARRIES THE VITAMIN D STEROLS CC AND PREVENTS POLYMERIZATION OF ACTIN BY BINDING ITS MONOMERS. DBP CC ASSOCIATES WITH MEMBRANE-BOUND IMMUNOGLOBULIN ON THE SURFACE OF CC B-LYMPHOCYTES AND WITH IGG FC RECEPTOR ON THE MEMBRANES OF CC T-LYMPHOCYTES. CC -!- SUBCELLULAR LOCATION: EXTRACELLULAR. CC -!- DOMAIN: COMPOSED OF THREE HOMOLOGOUS DOMAINS. CC -!- SIMILARITY: ALBUMIN, ALPHA-FETOPROTEIN, AND VITAMIN D-BINDING CC PROTEIN CONSTITUTE A FAMILY OF RELATED SERUM PROTEINS. CC -!- POLYMORPHISM: OVER 80 VARIANTS OF HUMAN DBP HAVE BEEN IDENTIFIED. CC THE THREE MOST COMMON ALLELES ARE CALLED GC1F, GC1S, AND GC2. THE CC SEQUENCE SHOWN IS THAT OF THE GC2 ALLELE. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X03178; HSGCR. DR EMBL; M12654; HSDBP. DR EMBL; M17156; HSDBPG. DR PIR; A03237; VYHUD. DR PIR; A24066; A24066. DR PIR; A29096; A29096. DR MIM; 139200; 11TH EDITION. DR SWISS-2DPAGE; P02774; HUMAN. DR PROSITE; PS00212; ALBUMIN. KW ALBUMIN; GLYCOPROTEIN; VITAMIN D; TRANSPORT; PLASMA; ACTIN-BINDING; KW REPEAT; POLYMORPHISM; SIGNAL. FT SIGNAL 1 16 FT CHAIN 17 474 VITAMIN D-BINDING PROTEIN. FT REPEAT 22 199 1. FT REPEAT 218 385 2. FT REPEAT 404 474 3. FT DISULFID 29 75 BY SIMILARITY. FT DISULFID 74 83 BY SIMILARITY. FT DISULFID 96 112 BY SIMILARITY. FT DISULFID 111 122 BY SIMILARITY. FT DISULFID 145 190 BY SIMILARITY. FT DISULFID 189 198 BY SIMILARITY. FT DISULFID 220 266 BY SIMILARITY. FT DISULFID 265 273 BY SIMILARITY. FT DISULFID 286 300 BY SIMILARITY. FT DISULFID 299 311 BY SIMILARITY. FT DISULFID 335 376 BY SIMILARITY. FT DISULFID 375 384 BY SIMILARITY. FT DISULFID 407 453 BY SIMILARITY. FT DISULFID 452 462 BY SIMILARITY. FT CARBOHYD 288 288 POTENTIAL. FT VARIANT 432 432 D -> E (IN GC1S ALLELE). FT VARIANT 436 436 K -> T (IN GC1F AND GC1S ALLELES). FT CONFLICT 168 168 G -> E (IN REF. 2). FT CONFLICT 327 327 E -> R (IN REF. 2). SQ SEQUENCE 474 AA; 52963 MW; 1164403 CN; MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK KLAERLKAKL PDATPKELAK LVNKRSDFAS NCCSINSPPL YCDSEIDAEL KNIL //