ID CASK_CAPHI Reviewed; 192 AA. AC P02670; Q8SPM9; Q8SPN0; Q8SPV1; Q8SPW6; Q8SPW7; Q8SPW8; Q8WMV5; AC Q8WN74; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1992, sequence version 2. DT 16-APR-2014, entry version 89. DE RecName: Full=Kappa-casein; DE Short=Kappa-CN; DE Flags: Precursor; GN Name=CSN3; Synonyms=CSN10, CSNK; OS Capra hircus (Goat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Capra. OX NCBI_TaxID=9925; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Ssp. aegagrus; TISSUE=Mammary gland; RX PubMed=8226388; RA Coll A., Folch J.M., Sanchez A.; RT "Nucleotide sequence of the goat kappa-casein cDNA."; RL J. Anim. Sci. 71:2833-2833(1993). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8587130; DOI=10.1007/BF00173165; RA Chikuni K., Mori Y., Tabata T., Saito M., Monma M., Kosugiyama M.; RT "Molecular phylogeny based on the kappa-casein and cytochrome b RT sequences in the mammalian suborder ruminantia."; RL J. Mol. Evol. 41:859-866(1995). RN [3] RP PROTEIN SEQUENCE OF 22-192, AND PYROGLUTAMATE FORMATION AT Q-22. RX PubMed=16386026; DOI=10.1016/0014-5793(76)80972-6; RA Mercier J.-C., Chobert J.-M., Addeo F.; RT "Comparative study of the amino acid sequences of the RT caseinomacropeptides from seven species."; RL FEBS Lett. 72:208-214(1976). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-192, AND VARIANTS ARG-65; RP ILE-86; ILE-140 AND PRO-180. RX PubMed=11531704; DOI=10.1046/j.1365-2052.2001.00765.x; RA Caroli A., Jann O., Budelli E., Bolla P., Jaeger S., Erhardt G.; RT "Genetic polymorphism of goat kappa-casein (CSN3) in different breeds RT and characterization at DNA level."; RL Anim. Genet. 32:226-230(2001). RN [5] RP NUCLEOTIDE SEQUENCE OF 31-192, AND VARIANTS ILE-86; ILE-140; VAL-177 RP AND PRO-180. RX PubMed=11504385; RA Yahyaoui M.H., Coll A., Sanchez A., Folch J.M.; RT "Genetic polymorphism of the caprine kappa casein gene."; RL J. Dairy Res. 68:209-216(2001). RN [6] RP NUCLEOTIDE SEQUENCE OF 31-192, AND VARIANTS GLY-111 AND ILE-140. RA Angiolillo A., Yahyaoui M.H., Sanchez A., Pilla F., Folch J.M.; RT "Characterization of a new genetic variant in the caprine k-casein RT gene."; RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE OF 31-192, AND VARIANTS ARG-65; ILE-86; ILE-140 RP AND PRO-180. RA Yahyaoui M.H., Sanchez A., Folch J.M.; RT "Characterization of new genetic variants and genotyping of the RT caprine kappa casein gene."; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE OF 31-189, AND VARIANT ILE-140. RA Feligini M., Cubric-Curik V., Parma P., Curik I., Greppi G., Enne G.; RT "Polymorphism of kappa-casein in Italian goat breeds: a new ACRS-PCR RT designed DNA test for discrimination of A and B alleles."; RL Food Technol. Biotechnol. 40:293-298(2002). RN [9] RP PROTEIN SEQUENCE OF 127-192, AND PHOSPHORYLATION AT SER-172 AND RP SER-189. RX PubMed=1016651; RA Mercier J.-C., Addeo F., Pelissier J.-P.; RT "Primary structure of the casein macropeptide of caprine kappa RT casein."; RL Biochimie 58:1303-1310(1976). CC -!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing CC casein precipitation in milk. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk. CC -!- SIMILARITY: Belongs to the kappa-casein family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D14373; BAA03286.1; -; Genomic_DNA. DR EMBL; X60763; CAA43174.1; -; mRNA. DR EMBL; AY027868; AAK17010.1; -; Genomic_DNA. DR EMBL; AF485339; AAL90871.1; -; Genomic_DNA. DR EMBL; AF485340; AAL90872.1; -; Genomic_DNA. DR EMBL; AF485341; AAL90873.1; -; Genomic_DNA. DR EMBL; AF486523; AAL93193.1; -; Genomic_DNA. DR EMBL; AY090465; AAM12025.1; -; Genomic_DNA. DR EMBL; AY090466; AAM12026.1; -; Genomic_DNA. DR EMBL; AY090467; AAM12027.1; -; Genomic_DNA. DR EMBL; AF434988; AAL31535.1; -; Genomic_DNA. DR PIR; A94479; KKGT. DR PIR; S15513; S15513. DR RefSeq; NP_001272516.1; NM_001285587.1. DR UniGene; Chi.520; -. DR ProteinModelPortal; P02670; -. DR Allergome; 1242; Cap h 8. DR Allergome; 2969; Cap h 12. DR GeneID; 100861231; -. DR KEGG; chx:100861231; -. DR CTD; 1448; -. DR HOVERGEN; HBG005246; -. DR KO; K17282; -. DR PMAP-CutDB; P02670; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR InterPro; IPR000117; Casein_kappa. DR PANTHER; PTHR11470; PTHR11470; 1. DR Pfam; PF00997; Casein_kappa; 1. DR PIRSF; PIRSF002374; Casein_kappa; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Phosphoprotein; Polymorphism; KW Pyrrolidone carboxylic acid; Secreted; Signal. FT SIGNAL 1 21 FT CHAIN 22 192 Kappa-casein. FT /FTId=PRO_0000004492. FT SITE 126 127 Cleavage; by chymosin/rennin. FT MOD_RES 22 22 Pyrrolidone carboxylic acid. FT MOD_RES 148 148 Phosphoserine (By similarity). FT MOD_RES 172 172 Phosphoserine. FT MOD_RES 189 189 Phosphoserine. FT VARIANT 65 65 Q -> R (in allele CSN3-B). FT VARIANT 86 86 V -> I (in allele CSN3-B, allele C and FT allele G). FT VARIANT 111 111 D -> G (in allele E). FT VARIANT 140 140 V -> I (in allele CSN3-B, allele B, FT allele C, allele E, allele F and allele FT G). FT VARIANT 177 177 A -> V (in allele C). FT VARIANT 180 180 S -> P (in allele CSN3-B, allele C, FT allele F and allele G). FT CONFLICT 134 134 D -> N (in Ref. 3; AA sequence). SQ SEQUENCE 192 AA; 21441 MW; 009F5858F4BFB178 CRC64; MMKSFFLVVT ILALTLPFLG AQEQNQEQPI CCEKDERFFD DKIAKYIPIQ YVLSRYPSYG LNYYQQRPVA LINNQFLPYP YYAKPVAVRS PAQTLQWQVL PNTVPAKSCQ DQPTTLARHP HPHLSFMAIP PKKDQDKTEV PAINTIASAE PTVHSTPTTE AIVNTVDNPE ASSESIASAS ETNTAQVTST EV //