ID   CASK_CAPHI     STANDARD;      PRT;   192 AA.
AC   P02670; Q8SPM9; Q8SPN0; Q8SPV1; Q8SPW6; Q8SPW7; Q8SPW8; Q8WMV5;
AC   Q8WN74;
DT   21-JUL-1986 (Rel. 01, Created)
DT   01-AUG-1992 (Rel. 23, Last sequence update)
DT   15-JUN-2004 (Rel. 44, Last annotation update)
DE   Kappa casein precursor (Kappa-CN).
GN   CSN3 OR CSN10 OR CSNK.
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=Ssp. aegagrus; TISSUE=Mammary gland;
RX   MEDLINE=94042560; PubMed=8226388;
RA   Coll A., Folch J.M., Sanchez A.;
RT   "Nucleotide sequence of the goat kappa-casein cDNA.";
RL   J. Anim. Sci. 71:2833-2833(1993).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=96139018; PubMed=8587130;
RA   Chikuni K., Mori Y., Tabata T., Saito M., Monma M., Kosugiyama M.;
RT   "Molecular phylogeny based on the kappa-casein and cytochrome b
RT   sequences in the mammalian suborder Ruminantia.";
RL   J. Mol. Evol. 41:859-866(1995).
RN   [3]
RP   SEQUENCE OF 22-192.
RA   Mercier J.-C., Addeo F., Pelissier J.-P.;
RL   Unpublished results, cited by:
RL   Mercier J.-C., Chobert J.-M., Addeo F.;
RL   FEBS Lett. 72:208-214(1976).
RN   [4]
RP   SEQUENCE OF 31-192 FROM N.A., AND VARIANTS ARG-65; ILE-86; ILE-140 AND
RP   PRO-180.
RX   MEDLINE=21422902; PubMed=11531704;
RA   Caroli A., Jann O., Budelli E., Bolla P., Jaeger S., Erhardt G.;
RT   "Genetic polymorphism of goat kappa-casein (CSN3) in different breeds
RT   and characterization at DNA level.";
RL   Anim. Genet. 32:226-230(2001).
RN   [5]
RP   SEQUENCE OF 31-192 FROM N.A., AND VARIANTS ILE-86; ILE-140; VAL-177
RP   AND PRO-180.
RX   MEDLINE=21395138; PubMed=11504385;
RA   Yahyaoui M.H., Coll A., Sanchez A., Folch J.M.;
RT   "Genetic polymorphism of the caprine kappa casein gene.";
RL   J. Dairy Res. 68:209-216(2001).
RN   [6]
RP   SEQUENCE OF 31-192 FROM N.A., AND VARIANTS GLY-111 AND ILE-140.
RA   Angiolillo A., Yahyaoui M.H., Sanchez A., Pilla F., Folch J.M.;
RT   "Characterization of a new genetic variant in the caprine k-casein
RT   gene.";
RL   Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   SEQUENCE OF 31-192 FROM N.A., AND VARIANTS ARG-65; ILE-86; ILE-140 AND
RP   PRO-180.
RA   Yahyaoui M.H., Sanchez A., Folch J.M.;
RT   "Characterization of new genetic variants and genotyping of the
RT   caprine kappa casein gene.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   SEQUENCE OF 31-189 FROM N.A., AND VARIANT ILE-140.
RA   Feligini M., Cubric-Curik V., Parma P., Curik I., Greppi G., Enne G.;
RT   "Polymorphism of kappa-casein in Italian goat breeds: a new ACRS-PCR
RT   designed DNA test for discrimination of A and B alleles.";
RL   Food Technol. Biotechnol. 40:293-298(2002).
RN   [9]
RP   SEQUENCE OF 127-192.
RX   MEDLINE=77112689; PubMed=1016651;
RA   Mercier J.-C., Addeo F., Pelissier J.-P.;
RT   "Primary structure of the casein macropeptide of caprine kappa
RT   casein.";
RL   Biochimie 58:1303-1310(1976).
CC   -!- FUNCTION: Kappa casein stabilizes micelle formation, preventing
CC       casein precipitation in milk.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the kappa-casein family.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D14373; BAA03286.1; -.
DR   EMBL; D14371; BAA03286.1; JOINED.
DR   EMBL; D14372; BAA03286.1; JOINED.
DR   EMBL; X60763; CAA43174.1; -.
DR   EMBL; AY027868; AAK17010.1; -.
DR   EMBL; AF485339; AAL90871.1; -.
DR   EMBL; AF485340; AAL90872.1; -.
DR   EMBL; AF485341; AAL90873.1; -.
DR   EMBL; AF486523; AAL93193.1; -.
DR   EMBL; AY090465; AAM12025.1; -.
DR   EMBL; AY090466; AAM12026.1; -.
DR   EMBL; AY090467; AAM12027.1; -.
DR   EMBL; AF434988; AAL31535.1; -.
DR   PIR; S15513; S15513.
DR   InterPro; IPR000117; Casein_kappa.
DR   Pfam; PF00997; casein_kappa; 1.
DR   ProDom; PD003689; Casein_kappa; 1.
KW   Milk; Phosphorylation; Glycoprotein; Signal; Polymorphism;
KW   Pyrrolidone carboxylic acid.
FT   SIGNAL        1     21
FT   CHAIN        22    192       Kappa casein.
FT   SITE        126    127       Cleavage (by chymosin (=rennin)).
FT   MOD_RES      22     22       Pyrrolidone carboxylic acid.
FT   MOD_RES     172    172       Phosphoserine.
FT   MOD_RES     189    189       Phosphoserine.
FT   VARIANT      65     65       Q -> R (in allele CSN3-B).
FT   VARIANT      86     86       V -> I (in allele CSN3-B, allele C and
FT                                allele G).
FT   VARIANT     111    111       D -> G (in allele E).
FT   VARIANT     140    140       V -> I (in allele CSN3-B, allele B,
FT                                allele C, allele E, allele F and allele
FT                                G).
FT   VARIANT     177    177       A -> V (in allele C).
FT   VARIANT     180    180       S -> P (in allele CSN3-B, allele C,
FT                                allele F and allele G).
FT   CONFLICT    134    134       D -> N (in Ref. 3).
SQ   SEQUENCE   192 AA;  21441 MW;  009F5858F4BFB178 CRC64;
     MMKSFFLVVT ILALTLPFLG AQEQNQEQPI CCEKDERFFD DKIAKYIPIQ YVLSRYPSYG
     LNYYQQRPVA LINNQFLPYP YYAKPVAVRS PAQTLQWQVL PNTVPAKSCQ DQPTTLARHP
     HPHLSFMAIP PKKDQDKTEV PAINTIASAE PTVHSTPTTE AIVNTVDNPE ASSESIASAS
     ETNTAQVTST EV
//