ID   CASK_CAPHI     STANDARD;      PRT;   192 AA.
AC   P02670;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   01-AUG-1992 (REL. 23, LAST SEQUENCE UPDATE)
DT   01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE)
DE   KAPPA CASEIN PRECURSOR.
GN   CSN3 OR CSNK.
OS   CAPRA HIRCUS (GOAT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC   ARTIODACTYLA; RUMINANTIA; PECORA; BOVOIDEA; BOVIDAE; CAPRINAE; CAPRA.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=SSP. AEGAGRUS; TISSUE=MAMMARY GLAND;
RX   MEDLINE; 94042560.
RA   COLL A., FOLCH J.M., SANCHEZ A.;
RT   "Nucleotide sequence of the goat kappa-casein cDNA.";
RL   J. ANIM. SCI. 71:2833-2833(1993).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 96139018.
RA   CHIKUNI K., MORI Y., TABATA T., SAITO M., MONMA M., KOSUGIYAMA M.;
RT   "Molecular phylogeny based on the kappa-casein and cytochrome b
RT   sequences in the mammalian suborder Ruminantia.";
RL   J. MOL. EVOL. 41:859-866(1995).
RN   [3]
RP   SEQUENCE OF 22-192.
RA   MERCIER J.-C., ADDEO F., PELISSIER J.-P.;
RT   "Comparative study of the amino acid sequences of the
RT   caseinomacropeptides from seven species.";
RL   UNPUBLISHED RESULTS, CITED BY:
RL   MERCIER J.-C., CHOBERT J.-M., ADDEO F.;
RL   FEBS LETT. 72:208-214(1976).
RN   [4]
RP   SEQUENCE OF 127-192.
RX   MEDLINE; 77112689.
RA   MERCIER J.-C., ADDEO F., PELISSIER J.-P.;
RT   "Primary structure of the casein macropeptide of caprine kappa
RT   casein.";
RL   BIOCHIMIE 58:1303-1310(1976).
CC   -!- FUNCTION: KAPPA CASEIN STABILIZES MICELLE FORMATION, PREVENTING
CC       CASEIN PRECIPITATION IN MILK.
CC   -!- SUBCELLULAR LOCATION: EXTRACELLULAR.
CC   -!- TISSUE SPECIFICITY: MAMMARY GLAND; MILK.
CC   -!- SIMILARITY: BELONGS TO THE KAPPA-CASEIN FAMILY.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D14373; D1003796; -.
DR   EMBL; D14371; D1003796; JOINED.
DR   EMBL; D14372; D1003796; JOINED.
DR   EMBL; X60763; G978; -.
DR   EMBL; D13465; -; NOT_ANNOTATED_CDS.
DR   PIR; A03114; KKGT.
DR   PIR; S15513; S15513.
DR   PFAM; PF00997; casein_kappa; 1.
KW   MILK; PHOSPHORYLATION; GLYCOPROTEIN; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22    192       KAPPA CASEIN.
FT   SITE        126    127       CLEAVAGE (BY CHYMOSIN (=RENNIN)).
FT   MOD_RES      22     22       PYRROLIDONE CARBOXYLIC ACID.
FT   MOD_RES     172    172       PHOSPHORYLATION.
FT   MOD_RES     189    189       PHOSPHORYLATION.
FT   VARIANT     140    140       V -> I.
FT   CONFLICT    134    134       D -> N (IN REF. 3).
SQ   SEQUENCE   192 AA;  21441 MW;  4642F03E CRC32;
     MMKSFFLVVT ILALTLPFLG AQEQNQEQPI CCEKDERFFD DKIAKYIPIQ YVLSRYPSYG
     LNYYQQRPVA LINNQFLPYP YYAKPVAVRS PAQTLQWQVL PNTVPAKSCQ DQPTTLARHP
     HPHLSFMAIP PKKDQDKTEV PAINTIASAE PTVHSTPTTE AIVNTVDNPE ASSESIASAS
     ETNTAQVTST EV
//