ID   CASK_CAPHI              Reviewed;         192 AA.
AC   P02670; Q8SPM9; Q8SPN0; Q8SPV1; Q8SPW6; Q8SPW7; Q8SPW8; Q8WMV5;
AC   Q8WN74;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 2.
DT   10-MAY-2017, entry version 101.
DE   RecName: Full=Kappa-casein;
DE            Short=Kappa-CN;
DE   Flags: Precursor;
GN   Name=CSN3; Synonyms=CSN10, CSNK;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Ssp. aegagrus; TISSUE=Mammary gland;
RX   PubMed=8226388;
RA   Coll A., Folch J.M., Sanchez A.;
RT   "Nucleotide sequence of the goat kappa-casein cDNA.";
RL   J. Anim. Sci. 71:2833-2833(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8587130; DOI=10.1007/BF00173165;
RA   Chikuni K., Mori Y., Tabata T., Saito M., Monma M., Kosugiyama M.;
RT   "Molecular phylogeny based on the kappa-casein and cytochrome b
RT   sequences in the mammalian suborder ruminantia.";
RL   J. Mol. Evol. 41:859-866(1995).
RN   [3]
RP   PROTEIN SEQUENCE OF 22-192, AND PYROGLUTAMATE FORMATION AT GLN-22.
RX   PubMed=16386026; DOI=10.1016/0014-5793(76)80972-6;
RA   Mercier J.-C., Chobert J.-M., Addeo F.;
RT   "Comparative study of the amino acid sequences of the
RT   caseinomacropeptides from seven species.";
RL   FEBS Lett. 72:208-214(1976).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-192, AND VARIANTS ARG-65;
RP   ILE-86; ILE-140 AND PRO-180.
RX   PubMed=11531704; DOI=10.1046/j.1365-2052.2001.00765.x;
RA   Caroli A., Jann O., Budelli E., Bolla P., Jaeger S., Erhardt G.;
RT   "Genetic polymorphism of goat kappa-casein (CSN3) in different breeds
RT   and characterization at DNA level.";
RL   Anim. Genet. 32:226-230(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 31-192, AND VARIANTS ILE-86; ILE-140; VAL-177
RP   AND PRO-180.
RX   PubMed=11504385;
RA   Yahyaoui M.H., Coll A., Sanchez A., Folch J.M.;
RT   "Genetic polymorphism of the caprine kappa casein gene.";
RL   J. Dairy Res. 68:209-216(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE OF 31-192, AND VARIANTS GLY-111 AND ILE-140.
RA   Angiolillo A., Yahyaoui M.H., Sanchez A., Pilla F., Folch J.M.;
RT   "Characterization of a new genetic variant in the caprine k-casein
RT   gene.";
RL   Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE OF 31-192, AND VARIANTS ARG-65; ILE-86; ILE-140
RP   AND PRO-180.
RA   Yahyaoui M.H., Sanchez A., Folch J.M.;
RT   "Characterization of new genetic variants and genotyping of the
RT   caprine kappa casein gene.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE OF 31-189, AND VARIANT ILE-140.
RA   Feligini M., Cubric-Curik V., Parma P., Curik I., Greppi G., Enne G.;
RT   "Polymorphism of kappa-casein in Italian goat breeds: a new ACRS-PCR
RT   designed DNA test for discrimination of A and B alleles.";
RL   Food Technol. Biotechnol. 40:293-298(2002).
RN   [9]
RP   PROTEIN SEQUENCE OF 127-192, AND PHOSPHORYLATION AT SER-172 AND
RP   SER-189.
RX   PubMed=1016651;
RA   Mercier J.-C., Addeo F., Pelissier J.-P.;
RT   "Primary structure of the casein macropeptide of caprine kappa
RT   casein.";
RL   Biochimie 58:1303-1310(1976).
CC   -!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing
CC       casein precipitation in milk.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the kappa-casein family. {ECO:0000305}.
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DR   EMBL; D14373; BAA03286.1; -; Genomic_DNA.
DR   EMBL; X60763; CAA43174.1; -; mRNA.
DR   EMBL; AY027868; AAK17010.1; -; Genomic_DNA.
DR   EMBL; AF485339; AAL90871.1; -; Genomic_DNA.
DR   EMBL; AF485340; AAL90872.1; -; Genomic_DNA.
DR   EMBL; AF485341; AAL90873.1; -; Genomic_DNA.
DR   EMBL; AF486523; AAL93193.1; -; Genomic_DNA.
DR   EMBL; AY090465; AAM12025.1; -; Genomic_DNA.
DR   EMBL; AY090466; AAM12026.1; -; Genomic_DNA.
DR   EMBL; AY090467; AAM12027.1; -; Genomic_DNA.
DR   EMBL; AF434988; AAL31535.1; -; Genomic_DNA.
DR   PIR; A94479; KKGT.
DR   PIR; S15513; S15513.
DR   RefSeq; NP_001272516.1; NM_001285587.1.
DR   UniGene; Chi.520; -.
DR   ProteinModelPortal; P02670; -.
DR   Allergome; 1242; Cap h 8.
DR   Allergome; 2969; Cap h 12.
DR   iPTMnet; P02670; -.
DR   GeneID; 100861231; -.
DR   KEGG; chx:100861231; -.
DR   CTD; 1448; -.
DR   HOVERGEN; HBG005246; -.
DR   KO; K17282; -.
DR   OrthoDB; EOG091G105X; -.
DR   PMAP-CutDB; P02670; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000117; Casein_kappa.
DR   PANTHER; PTHR11470; PTHR11470; 1.
DR   Pfam; PF00997; Casein_kappa; 1.
DR   PIRSF; PIRSF002374; Casein_kappa; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Milk protein; Phosphoprotein;
KW   Polymorphism; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL        1     21       {ECO:0000269|PubMed:16386026}.
FT   CHAIN        22    192       Kappa-casein.
FT                                /FTId=PRO_0000004492.
FT   SITE        126    127       Cleavage; by chymosin/rennin.
FT   MOD_RES      22     22       Pyrrolidone carboxylic acid.
FT                                {ECO:0000269|PubMed:16386026}.
FT   MOD_RES     148    148       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P02668}.
FT   MOD_RES     172    172       Phosphoserine; alternate.
FT                                {ECO:0000269|PubMed:1016651}.
FT   MOD_RES     189    189       Phosphoserine.
FT                                {ECO:0000269|PubMed:1016651}.
FT   CARBOHYD    152    152       O-linked (GalNAc...) threonine.
FT                                {ECO:0000250|UniProtKB:P02668}.
FT   CARBOHYD    155    155       O-linked (GalNAc...) serine.
FT                                {ECO:0000250|UniProtKB:P02668}.
FT   CARBOHYD    156    156       O-linked (GalNAc...) threonine.
FT                                {ECO:0000250|UniProtKB:P02668}.
FT   CARBOHYD    159    159       O-linked (GalNAc...) threonine.
FT                                {ECO:0000250|UniProtKB:P02668}.
FT   CARBOHYD    165    165       O-linked (GalNAc...) threonine.
FT                                {ECO:0000250|UniProtKB:P02668}.
FT   CARBOHYD    172    172       O-linked (GalNAc...) serine; alternate.
FT                                {ECO:0000250|UniProtKB:P02668}.
FT   CARBOHYD    188    188       O-linked (GalNAc...) threonine.
FT                                {ECO:0000250|UniProtKB:P02668}.
FT   VARIANT      65     65       Q -> R (in allele CSN3-B).
FT                                {ECO:0000269|PubMed:11531704,
FT                                ECO:0000269|Ref.7}.
FT   VARIANT      86     86       V -> I (in allele CSN3-B, allele C and
FT                                allele G). {ECO:0000269|PubMed:11504385,
FT                                ECO:0000269|PubMed:11531704,
FT                                ECO:0000269|Ref.7}.
FT   VARIANT     111    111       D -> G (in allele E).
FT                                {ECO:0000269|Ref.6}.
FT   VARIANT     140    140       V -> I (in allele CSN3-B, allele B,
FT                                allele C, allele E, allele F and allele
FT                                G). {ECO:0000269|PubMed:11504385,
FT                                ECO:0000269|PubMed:11531704,
FT                                ECO:0000269|Ref.6, ECO:0000269|Ref.7,
FT                                ECO:0000269|Ref.8}.
FT   VARIANT     177    177       A -> V (in allele C).
FT                                {ECO:0000269|PubMed:11504385}.
FT   VARIANT     180    180       S -> P (in allele CSN3-B, allele C,
FT                                allele F and allele G).
FT                                {ECO:0000269|PubMed:11504385,
FT                                ECO:0000269|PubMed:11531704,
FT                                ECO:0000269|Ref.7}.
FT   CONFLICT    134    134       D -> N (in Ref. 3; AA sequence).
FT                                {ECO:0000305}.
SQ   SEQUENCE   192 AA;  21441 MW;  009F5858F4BFB178 CRC64;
     MMKSFFLVVT ILALTLPFLG AQEQNQEQPI CCEKDERFFD DKIAKYIPIQ YVLSRYPSYG
     LNYYQQRPVA LINNQFLPYP YYAKPVAVRS PAQTLQWQVL PNTVPAKSCQ DQPTTLARHP
     HPHLSFMAIP PKKDQDKTEV PAINTIASAE PTVHSTPTTE AIVNTVDNPE ASSESIASAS
     ETNTAQVTST EV
//