ID H2B_MARGL STANDARD; PRT; 120 AA. AC P02285; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 25-JUL-2006, entry version 43. DE Histone H2B, sperm. OS Marthasterias glacialis (Spiny starfish). OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; OC Asteroidea; Forcipulatacea; Forcipulatida; Asteriidae; Marthasterias. OX NCBI_TaxID=7609; RN [1] RP PROTEIN SEQUENCE. RX MEDLINE=80245951; PubMed=7398625; RA Strickland M., Strickland W.N., von Holt C.; RT "The histone H2B from the sperm cell of the starfish Marthasterias RT glacialis."; RL Eur. J. Biochem. 106:541-548(1980). CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and CC compact DNA into chromatin, limiting DNA accessibility to the CC cellular machineries which require DNA as a template. Histones CC thereby play a central role in transcription regulation, DNA CC repair, DNA replication and chromosomal stability. DNA CC accessibility is regulated via a complex set of post-translational CC modifications of histones, also called histone code, and CC nucleosome remodelling. CC -!- SUBUNIT: The nucleosome is a histone octamer containing two CC molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 CC heterotetramer and two H2A-H2B heterodimers. The octamer wraps CC approximately 147 bp of DNA. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- PTM: Monoubiquitination of Lys-115 gives a specific tag for CC epigenetic transcriptional activation and is also prerequisite for CC histone H3 Lys-4 and Lys-79 methylation (By similarity). CC -!- SIMILARITY: Belongs to the histone H2B family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; A02612; HSSF2M. DR HSSP; P02281; 1KX3. DR SMR; P02285; 28-119. DR InterPro; IPR007124; Hist_TAF. DR InterPro; IPR009072; Histone-fold. DR InterPro; IPR007125; Histone_core_D. DR InterPro; IPR000558; Histone_H2B. DR Pfam; PF00125; Histone; 1. DR PRINTS; PR00621; HISTONEH2B. DR ProDom; PD000497; Histone_H2B; 1. DR SMART; SM00427; H2B; 1. DR PROSITE; PS00357; HISTONE_H2B; 1. KW Chromosomal protein; Direct protein sequencing; DNA-binding; KW Methylation; Nuclear protein; Nucleosome core; Ubl conjugation. FT INIT_MET 0 0 FT CHAIN 1 120 Histone H2B, sperm. FT /FTId=PRO_0000071887. FT MOD_RES 1 1 N,N-dimethylproline (Probable). FT CROSSLNK 115 115 Glycyl lysine isopeptide (Lys-Gly) FT (interchain with G-Cter in ubiquitin) (By FT similarity). SQ SEQUENCE 120 AA; 13349 MW; EC493269B7915524 CRC64; PPKSGKGQKK AGKAKGAPRS DKKRRRKRKE SYGIYIYKVM KQVHPDTGIS SRAMSIMNSF VNDIFERIAA EASRLAHYNK KSTITSREVQ TAVRLLLPGE LAKHAVSEGT KAVTKYTTSK //