ID IGH1M_MOUSE STANDARD; PRT; 393 AA. AC P01869; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1991, sequence version 2. DT 21-MAR-2006, entry version 56. DE Ig gamma-1 chain C region, membrane-bound form. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=80045036; PubMed=115593; DOI=10.1016/0092-8674(79)90072-2; RA Honjo T., Obata M., Yamawaki-Kataoka Y., Kataoka T., Kawakami T., RA Takahashi N., Mano Y.; RT "Cloning and complete nucleotide sequence of mouse immunoglobulin RT gamma 1 chain gene."; RL Cell 18:559-568(1979). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 323-393. RX MEDLINE=82197626; PubMed=6804950; RA Tyler B.M., Cowman A.F., Gerondakis S.D., Adams J.M., Bernard O.; RT "mRNA for surface immunoglobulin gamma chains encodes a highly RT conserved transmembrane sequence and a 28-residue intracellular RT domain."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2008-2012(1982). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 323-366. RX MEDLINE=82115295; PubMed=6799207; DOI=10.1016/0092-8674(81)90029-5; RA Rogers J., Choi E., Souza L., Carter C., Word C.J., Kuehl M., RA Eisenberg D., Wall R.; RT "Gene segments encoding transmembrane carboxyl termini of RT immunoglobulin gamma chains."; RL Cell 26:19-27(1981). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44. RX MEDLINE=82222190; PubMed=6283537; RA Yamawaki-Kataoka Y., Nakai S., Miyata T., Honjo T.; RT "Nucleotide sequences of gene segments encoding membrane domains of RT immunoglobulin gamma chains."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2623-2627(1982). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Membrane-bound; CC IsoId=P01869-1; Sequence=Displayed; CC Name=Secreted; CC IsoId=P01868-1; Sequence=External; CC Note=May be the major isoform; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J00453; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; B02159; G1MSM. DR PDB; 15C8; X-ray; H=1-98. DR PDB; 1ACY; X-ray; H=1-100. DR PDB; 1AE6; X-ray; H=1-98. DR PDB; 1CIC; X-ray; D=1-102. DR PDB; 1CL7; X-ray; I=21-102. DR PDB; 1F11; X-ray; B/D=1-102. DR PDB; 1F58; X-ray; H=1-102. DR PDB; 1IGY; X-ray; B/D=1-320. DR PDB; 1KC5; X-ray; H=1-101. DR PDB; 1KCR; X-ray; H=1-102. DR PDB; 1KEN; X-ray; H/T=1-101. DR PDB; 1ORS; X-ray; B=1-103. DR PDB; 1S5I; X-ray; H=1-102. DR PDB; 25C8; X-ray; H=1-98. DR Ensembl; ENSMUSG00000037435; Mus musculus. DR MGI; MGI:96446; Igh-4. DR LinkHub; P01869; -. DR GO; GO:0042571; C:immunoglobulin complex, circulating; IDA. DR GO; GO:0003823; F:antigen binding; IDA. DR GO; GO:0019733; P:antibacterial humoral response (sensu Verte...; IDA. DR GO; GO:0001788; P:antibody-dependent cellular cytotoxicity; IDA. DR GO; GO:0006958; P:complement activation, classical pathway; IDA. DR GO; GO:0042830; P:defense response to pathogenic bacteria; IDA. DR GO; GO:0006911; P:phagocytosis, engulfment; IDA. DR GO; GO:0006910; P:phagocytosis, recognition; IDA. DR GO; GO:0050778; P:positive regulation of immune response; IDA. DR GO; GO:0050766; P:positive regulation of phagocytosis; IDA. DR GO; GO:0001812; P:positive regulation of type I hypersensitivity; IDA. DR GO; GO:0001798; P:positive regulation of type IIa hypersensit...; IDA. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003597; Ig_c1. DR InterPro; IPR003006; Ig_MHC. DR InterPro; IPR013151; Immunoglobulin. DR Pfam; PF07654; C1-set; 2. DR Pfam; PF00047; ig; 1. DR SMART; SM00407; IGc1; 2. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS00290; IG_MHC; FALSE_NEG. KW 3D-structure; Alternative splicing; Glycoprotein; KW Immunoglobulin C region; Immunoglobulin domain; Membrane; KW Transmembrane. FT CHAIN <1 393 Ig gamma-1 chain C region, membrane-bound FT form. FT /FTId=PRO_0000153583. FT TRANSMEM 340 357 Potential. FT TOPO_DOM 358 393 Cytoplasmic (Potential). FT REGION 1 97 CH1. FT REGION 98 110 Hinge. FT REGION 111 217 CH2. FT REGION 218 324 CH3. FT CARBOHYD 174 174 N-linked (GlcNAc...). FT DISULFID 27 82 FT DISULFID 102 102 Interchain (with a light chain). FT DISULFID 104 104 Interchain (with a heavy chain). FT DISULFID 107 107 Interchain (with a heavy chain). FT DISULFID 109 109 Interchain (with a heavy chain). FT DISULFID 138 198 FT DISULFID 244 302 FT NON_TER 1 1 FT STRAND 4 4 FT STRAND 7 11 FT STRAND 16 17 FT STRAND 20 35 FT STRAND 38 41 FT HELIX 42 44 FT TURN 45 45 FT STRAND 46 46 FT TURN 48 49 FT STRAND 50 52 FT STRAND 56 71 FT TURN 72 77 FT STRAND 78 78 FT STRAND 81 86 FT HELIX 87 89 FT TURN 90 90 FT STRAND 91 96 FT STRAND 100 100 FT STRAND 112 114 FT STRAND 117 120 FT HELIX 124 128 FT STRAND 129 129 FT TURN 130 131 FT STRAND 132 132 FT STRAND 135 140 FT STRAND 145 146 FT STRAND 152 152 FT STRAND 154 158 FT STRAND 161 161 FT STRAND 165 165 FT STRAND 174 176 FT STRAND 183 184 FT HELIX 187 192 FT TURN 193 193 FT STRAND 197 197 FT STRAND 200 200 FT STRAND 203 204 FT STRAND 206 207 FT STRAND 218 218 FT STRAND 221 221 FT STRAND 226 228 FT STRAND 232 250 FT STRAND 252 252 FT STRAND 254 260 FT TURN 261 262 FT STRAND 263 263 FT STRAND 266 266 FT STRAND 269 270 FT STRAND 277 279 FT STRAND 281 290 FT HELIX 291 295 FT TURN 296 297 FT STRAND 300 306 FT TURN 307 308 FT STRAND 309 309 FT HELIX 310 312 FT STRAND 314 318 SQ SEQUENCE 393 AA; 43387 MW; 4CC88343B7A1CE27 CRC64; AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV HTFPAVLQSD LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR DCGCKPCICT VPEVSSVFIF PPKPKDVLTI TLTPKVTCVV VDISKDDPEV QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV SELPIMHQDW LNGKEFKCRV NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV SLTCMITDFF PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF TCSVLHEGLH NHHTEKSLSH SPGLQLDETC AEAQDGELDG LWTTITIFIS LFLLSVCYSA AVTLFKVKWI FSSVVELKQT LVPEYKNMIG QAP //