ID IGH1M_MOUSE STANDARD; PRT; 393 AA. AC P01869; DT 21-JUL-1986 (Rel. 01, Created) DT 01-AUG-1991 (Rel. 19, Last sequence update) DT 13-SEP-2005 (Rel. 48, Last annotation update) DE Ig gamma-1 chain C region, membrane-bound form. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=80045036; PubMed=115593; DOI=10.1016/0092-8674(79)90072-2; RA Honjo T., Obata M., Yamawaki-Kataoka Y., Kataoka T., Kawakami T., RA Takahashi N., Mano Y.; RT "Cloning and complete nucleotide sequence of mouse immunoglobulin RT gamma 1 chain gene."; RL Cell 18:559-568(1979). RN [2] RP NUCLEOTIDE SEQUENCE OF 323-393. RX MEDLINE=82197626; PubMed=6804950; RA Tyler B.M., Cowman A.F., Gerondakis S.D., Adams J.M., Bernard O.; RT "mRNA for surface immunoglobulin gamma chains encodes a highly RT conserved transmembrane sequence and a 28-residue intracellular RT domain."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2008-2012(1982). RN [3] RP NUCLEOTIDE SEQUENCE OF 323-366. RX MEDLINE=82115295; PubMed=6799207; DOI=10.1016/0092-8674(81)90029-5; RA Rogers J., Choi E., Souza L., Carter C., Word C.J., Kuehl M., RA Eisenberg D., Wall R.; RT "Gene segments encoding transmembrane carboxyl termini of RT immunoglobulin gamma chains."; RL Cell 26:19-27(1981). RN [4] RP NUCLEOTIDE SEQUENCE OF 1-44. RX MEDLINE=82222190; PubMed=6283537; RA Yamawaki-Kataoka Y., Nakai S., Miyata T., Honjo T.; RT "Nucleotide sequences of gene segments encoding membrane domains of RT immunoglobulin gamma chains."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2623-2627(1982). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Membrane-bound; CC IsoId=P01869-1; Sequence=Displayed; CC Name=Secreted; CC IsoId=P01868-1; Sequence=External; CC Note=May be the major isoform; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J00453; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; B02159; G1MSM. DR PDB; 15C8; X-ray; H=1-98. DR PDB; 1ACY; X-ray; H=1-100. DR PDB; 1AE6; X-ray; H=1-98. DR PDB; 1CIC; X-ray; D=3-102. DR PDB; 1CL7; X-ray; I=21-102. DR PDB; 1F11; X-ray; B/D=1-102. DR PDB; 1F58; X-ray; H=1-102. DR PDB; 1IGY; X-ray; B/D=1-320. DR PDB; 1KC5; X-ray; H=3-101. DR PDB; 1KCR; X-ray; H=3-102. DR PDB; 1KEN; X-ray; H/T=1-101. DR PDB; 1ORS; X-ray; B=1-103. DR PDB; 1S5I; X-ray; H=1-102. DR PDB; 25C8; X-ray; H=1-98. DR Ensembl; ENSMUSG00000037435; Mus musculus. DR MGI; MGI:96446; Igh-4. DR GO; GO:0042571; C:immunoglobulin complex, circulating; IDA. DR GO; GO:0003823; F:antigen binding; IDA. DR GO; GO:0019733; P:antibacterial humoral response (sensu Verte...; IDA. DR GO; GO:0001788; P:antibody-dependent cellular cytotoxicity; IDA. DR GO; GO:0006958; P:complement activation, classical pathway; IDA. DR GO; GO:0042830; P:defense response to pathogenic bacteria; IDA. DR GO; GO:0006911; P:phagocytosis, engulfment; IDA. DR GO; GO:0006910; P:phagocytosis, recognition; IDA. DR GO; GO:0050778; P:positive regulation of immune response; IDA. DR GO; GO:0050766; P:positive regulation of phagocytosis; IDA. DR GO; GO:0001812; P:positive regulation of type I hypersensitivity; IDA. DR GO; GO:0001798; P:positive regulation of type IIa hypersensit...; IDA. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003597; Ig_c1. DR InterPro; IPR003006; Ig_MHC. DR Pfam; PF07654; C1-set; 3. DR SMART; SM00407; IGc1; 2. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS00290; IG_MHC; FALSE_NEG. KW 3D-structure; Alternative splicing; Glycoprotein; KW Immunoglobulin C region; Immunoglobulin domain; Transmembrane. FT TRANSMEM 340 357 Potential. FT TOPO_DOM 358 393 Cytoplasmic (Potential). FT REGION 1 97 CH1. FT REGION 98 110 Hinge. FT REGION 111 217 CH2. FT REGION 218 324 CH3. FT CARBOHYD 174 174 N-linked (GlcNAc...). FT DISULFID 27 82 FT DISULFID 102 102 Interchain (with a light chain). FT DISULFID 104 104 Interchain (with a heavy chain). FT DISULFID 107 107 Interchain (with a heavy chain). FT DISULFID 109 109 Interchain (with a heavy chain). FT DISULFID 138 198 FT DISULFID 244 302 FT NON_TER 1 1 FT STRAND 4 4 FT STRAND 7 11 FT STRAND 22 33 FT STRAND 38 41 FT HELIX 42 44 FT TURN 45 45 FT STRAND 46 46 FT TURN 48 49 FT STRAND 50 52 FT STRAND 56 58 FT TURN 59 60 FT STRAND 61 71 FT TURN 72 77 FT STRAND 81 86 FT HELIX 87 89 FT TURN 90 90 FT STRAND 91 96 SQ SEQUENCE 393 AA; 43387 MW; 4CC88343B7A1CE27 CRC64; AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV HTFPAVLQSD LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR DCGCKPCICT VPEVSSVFIF PPKPKDVLTI TLTPKVTCVV VDISKDDPEV QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV SELPIMHQDW LNGKEFKCRV NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV SLTCMITDFF PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF TCSVLHEGLH NHHTEKSLSH SPGLQLDETC AEAQDGELDG LWTTITIFIS LFLLSVCYSA AVTLFKVKWI FSSVVELKQT LVPEYKNMIG QAP //