ID GC1M_MOUSE STANDARD; PRT; 393 AA. AC P01869; DT 21-JUL-1986 (Rel. 01, Created) DT 01-AUG-1991 (Rel. 19, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Ig gamma-1 chain C region, membrane-bound form. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=80045036; PubMed=115593; RA Honjo T., Obata M., Yamawaki-Kataoka Y., Kataoka T., Kawakami T., RA Takahashi N., Mano Y.; RT "Cloning and complete nucleotide sequence of mouse immunoglobulin RT gamma 1 chain gene."; RL Cell 18:559-568(1979). RN [2] RP SEQUENCE OF 323-393 FROM N.A. RX MEDLINE=82197626; PubMed=6804950; RA Tyler B.M., Cowman A.F., Gerondakis S.D., Adams J.M., Bernard O.; RT "mRNA for surface immunoglobulin gamma chains encodes a highly RT conserved transmembrane sequence and a 28-residue intracellular RT domain."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2008-2012(1982). RN [3] RP SEQUENCE OF 323-366 FROM N.A. RX MEDLINE=82115295; PubMed=6799207; RA Rogers J., Choi E., Souza L., Carter C., Word C.J., Kuehl M., RA Eisenberg D., Wall R.; RT "Gene segments encoding transmembrane carboxyl termini of RT immunoglobulin gamma chains."; RL Cell 26:19-27(1981). RN [4] RP SEQUENCE OF 1-44 FROM N.A. RX MEDLINE=82222190; PubMed=6283537; RA Yamawaki-Kataoka Y., Nakai S., Miyata T., Honjo T.; RT "Nucleotide sequences of gene segments encoding membrane domains of RT immunoglobulin gamma chains."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2623-2627(1982). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Membrane-bound; CC IsoId=P01869-1; Sequence=Displayed; CC Name=Secreted; CC IsoId=P01868-1; Sequence=External; CC Note=May be the major isoform; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J00453; -; NOT_ANNOTATED_CDS. DR PIR; B02159; G1MSM. DR PDB; 15C8; 23-MAR-99. DR PDB; 1AE6; 18-MAR-98. DR PDB; 1CL7; 12-JAN-00. DR PDB; 1F11; 06-FEB-01. DR PDB; 1F58; 29-DEC-99. DR PDB; 1IGY; 15-APR-98. DR PDB; 1KC5; 24-JUL-02. DR PDB; 1KCR; 11-MAY-02. DR PDB; 1ORS; 06-MAY-03. DR PDB; 25C8; 09-JUL-99. DR MGD; MGI:96446; Igh-4. DR GO; GO:0042571; C:immunoglobulin complex, circulating; IDA. DR GO; GO:0003823; F:antigen binding; IDA. DR GO; GO:0019733; P:antibacterial humoral response (sensu Verte...; IDA. DR GO; GO:0001788; P:antibody-dependent cellular cytotoxicity; IDA. DR GO; GO:0006958; P:complement activation, classical pathway; IDA. DR GO; GO:0042830; P:defense response to pathogenic bacteria; IDA. DR GO; GO:0016064; P:humoral defense mechanism (sensu Vertebrata); IDA. DR GO; GO:0050728; P:negative regulation of inflammatory response; IDA. DR GO; GO:0006910; P:phagocytosis, binding; IDA. DR GO; GO:0006911; P:phagocytosis, engulfment; IDA. DR GO; GO:0050778; P:positive regulation of immune response; IDA. DR GO; GO:0050729; P:positive regulation of inflammatory response; IDA. DR GO; GO:0050766; P:positive regulation of phagocytosis; IDA. DR GO; GO:0016068; P:type I hypersensitivity; IDA. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003597; Ig_c1. DR InterPro; IPR003006; Ig_MHC. DR Pfam; PF00047; ig; 2. DR SMART; SM00407; IGc1; 2. DR PROSITE; PS50835; IG_LIKE; 3. DR PROSITE; PS00290; IG_MHC; 1. KW 3D-structure; Alternative splicing; Glycoprotein; KW Immunoglobulin C region; Immunoglobulin domain; Transmembrane. FT NON_TER 1 1 FT DOMAIN 1 97 CH1. FT DOMAIN 98 110 Hinge. FT DOMAIN 111 217 CH2. FT DOMAIN 218 324 CH3. FT DISULFID 27 82 FT DISULFID 102 102 Interchain (with a light chain). FT DISULFID 104 104 Interchain (with a heavy chain). FT DISULFID 107 107 Interchain (with a heavy chain). FT DISULFID 109 109 Interchain (with a heavy chain). FT DISULFID 138 198 FT CARBOHYD 174 174 N-linked (GlcNAc...). FT DISULFID 244 302 FT TRANSMEM 340 357 Potential. FT DOMAIN 358 393 Cytoplasmic (Potential). FT STRAND 4 4 FT STRAND 7 11 FT STRAND 22 33 FT STRAND 38 41 FT HELIX 42 44 FT TURN 45 45 FT STRAND 46 46 FT TURN 48 49 FT STRAND 50 52 FT STRAND 56 58 FT TURN 59 60 FT STRAND 61 71 FT TURN 72 77 FT STRAND 81 86 FT HELIX 87 89 FT TURN 90 90 FT STRAND 91 96 SQ SEQUENCE 393 AA; 43386 MW; 4CC88343B7A1CE27 CRC64; AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV HTFPAVLQSD LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR DCGCKPCICT VPEVSSVFIF PPKPKDVLTI TLTPKVTCVV VDISKDDPEV QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV SELPIMHQDW LNGKEFKCRV NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV SLTCMITDFF PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF TCSVLHEGLH NHHTEKSLSH SPGLQLDETC AEAQDGELDG LWTTITIFIS LFLLSVCYSA AVTLFKVKWI FSSVVELKQT LVPEYKNMIG QAP //