ID IGH1M_MOUSE Reviewed; 393 AA. AC P01869; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1991, sequence version 2. DT 19-FEB-2014, entry version 113. DE RecName: Full=Ig gamma-1 chain C region, membrane-bound form; GN Name=Ighg1; Synonyms=Igh-4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=115593; DOI=10.1016/0092-8674(79)90072-2; RA Honjo T., Obata M., Yamawaki-Kataoka Y., Kataoka T., Kawakami T., RA Takahashi N., Mano Y.; RT "Cloning and complete nucleotide sequence of mouse immunoglobulin RT gamma 1 chain gene."; RL Cell 18:559-568(1979). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 323-393. RX PubMed=6804950; DOI=10.1073/pnas.79.6.2008; RA Tyler B.M., Cowman A.F., Gerondakis S.D., Adams J.M., Bernard O.; RT "mRNA for surface immunoglobulin gamma chains encodes a highly RT conserved transmembrane sequence and a 28-residue intracellular RT domain."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2008-2012(1982). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 323-366. RX PubMed=6799207; DOI=10.1016/0092-8674(81)90029-5; RA Rogers J., Choi E., Souza L., Carter C., Word C.J., Kuehl M., RA Eisenberg D., Wall R.; RT "Gene segments encoding transmembrane carboxyl termini of RT immunoglobulin gamma chains."; RL Cell 26:19-27(1981). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44. RX PubMed=6283537; DOI=10.1073/pnas.79.8.2623; RA Yamawaki-Kataoka Y., Nakai S., Miyata T., Honjo T.; RT "Nucleotide sequences of gene segments encoding membrane domains of RT immunoglobulin gamma chains."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2623-2627(1982). CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein CC (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Membrane-bound; CC IsoId=P01869-1; Sequence=Displayed; CC Name=Secreted; CC IsoId=P01868-1; Sequence=External; CC Note=May be the major isoform; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J00453; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; B02159; G1MSM. DR UniGene; Mm.342177; -. DR PDB; 15C8; X-ray; 2.50 A; H=1-98. DR PDB; 1ACY; X-ray; 3.00 A; H=1-100. DR PDB; 1AE6; X-ray; 3.00 A; H=1-98. DR PDB; 1CIC; X-ray; 2.50 A; D=3-102. DR PDB; 1CL7; X-ray; 3.00 A; I=21-102. DR PDB; 1F11; X-ray; 3.00 A; B/D=1-102. DR PDB; 1F58; X-ray; 2.00 A; H=1-102. DR PDB; 1IGY; X-ray; 3.20 A; B/D=1-320. DR PDB; 1KC5; X-ray; 2.50 A; H=3-101. DR PDB; 1KCR; X-ray; 2.90 A; H=3-102. DR PDB; 1KEN; X-ray; 3.50 A; H/T=1-101. DR PDB; 1ORS; X-ray; 1.90 A; B=1-103. DR PDB; 1S5I; X-ray; 2.70 A; H=1-102. DR PDB; 25C8; X-ray; 2.00 A; H=2-98. DR PDB; 2AJS; X-ray; 1.70 A; H=1-100. DR PDB; 2AJU; X-ray; 1.50 A; H=1-100. DR PDB; 2AJV; X-ray; 1.50 A; H=1-100. DR PDB; 2AJX; X-ray; 1.85 A; H=1-100. DR PDB; 2AJY; X-ray; 2.10 A; H=1-100. DR PDB; 2AJZ; X-ray; 2.30 A; B/H=1-100. DR PDB; 2AK1; X-ray; 1.85 A; H=1-100. DR PDBsum; 15C8; -. DR PDBsum; 1ACY; -. DR PDBsum; 1AE6; -. DR PDBsum; 1CIC; -. DR PDBsum; 1CL7; -. DR PDBsum; 1F11; -. DR PDBsum; 1F58; -. DR PDBsum; 1IGY; -. DR PDBsum; 1KC5; -. DR PDBsum; 1KCR; -. DR PDBsum; 1KEN; -. DR PDBsum; 1ORS; -. DR PDBsum; 1S5I; -. DR PDBsum; 25C8; -. DR PDBsum; 2AJS; -. DR PDBsum; 2AJU; -. DR PDBsum; 2AJV; -. DR PDBsum; 2AJX; -. DR PDBsum; 2AJY; -. DR PDBsum; 2AJZ; -. DR PDBsum; 2AK1; -. DR ProteinModelPortal; P01869; -. DR SMR; P01869; 1-320. DR IntAct; P01869; 1. DR MINT; MINT-1852472; -. DR PaxDb; P01869; -. DR PRIDE; P01869; -. DR UCSC; uc007pgo.1; mouse. DR MGI; MGI:96446; Ighg1. DR eggNOG; NOG115036; -. DR HOVERGEN; HBG005814; -. DR InParanoid; P01869; -. DR EvolutionaryTrace; P01869; -. DR Genevestigator; P01869; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0003823; F:antigen binding; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 3. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR Pfam; PF07654; C1-set; 3. DR SMART; SM00407; IGc1; 2. DR PROSITE; PS50835; IG_LIKE; 3. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Complete proteome; KW Disulfide bond; Glycoprotein; Immunoglobulin C region; KW Immunoglobulin domain; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN <1 393 Ig gamma-1 chain C region, membrane-bound FT form. FT /FTId=PRO_0000153583. FT TRANSMEM 340 357 Helical; (Potential). FT TOPO_DOM 358 393 Cytoplasmic (Potential). FT REGION 1 97 CH1. FT REGION 98 110 Hinge. FT REGION 111 217 CH2. FT REGION 218 324 CH3. FT CARBOHYD 174 174 N-linked (GlcNAc...). FT DISULFID 27 82 FT DISULFID 102 102 Interchain (with a light chain). FT DISULFID 104 104 Interchain (with a heavy chain). FT DISULFID 107 107 Interchain (with a heavy chain). FT DISULFID 109 109 Interchain (with a heavy chain). FT DISULFID 138 198 FT DISULFID 244 302 FT NON_TER 1 1 FT STRAND 3 6 FT STRAND 7 11 FT STRAND 15 17 FT STRAND 20 35 FT STRAND 38 41 FT HELIX 42 44 FT STRAND 50 52 FT TURN 53 55 FT STRAND 56 71 FT TURN 72 77 FT STRAND 81 86 FT HELIX 87 89 FT STRAND 91 96 FT STRAND 113 117 FT STRAND 126 130 FT HELIX 131 135 FT STRAND 139 154 FT STRAND 157 160 FT TURN 161 164 FT STRAND 167 171 FT STRAND 175 179 FT STRAND 181 190 FT TURN 191 196 FT STRAND 199 205 FT TURN 206 209 FT STRAND 210 216 FT STRAND 226 228 FT STRAND 232 250 FT STRAND 254 260 FT STRAND 277 279 FT STRAND 281 290 FT HELIX 291 295 FT STRAND 300 306 FT HELIX 310 312 FT STRAND 314 318 SQ SEQUENCE 393 AA; 43387 MW; 4CC88343B7A1CE27 CRC64; AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV HTFPAVLQSD LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR DCGCKPCICT VPEVSSVFIF PPKPKDVLTI TLTPKVTCVV VDISKDDPEV QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV SELPIMHQDW LNGKEFKCRV NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV SLTCMITDFF PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF TCSVLHEGLH NHHTEKSLSH SPGLQLDETC AEAQDGELDG LWTTITIFIS LFLLSVCYSA AVTLFKVKWI FSSVVELKQT LVPEYKNMIG QAP //