ID   VIP$HUMAN      STANDARD;      PRT;   170 AA.
AC   P01282;
DT   21-JUL-1986  (REL. 01, CREATED)
DT   21-JUL-1986  (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAR-1989  (REL. 10, LAST ANNOTATION UPDATE)
DE   VASOACTIVE INTESTINAL PEPTIDE PRECURSOR (VIP).
OS   HUMAN (HOMO SAPIENS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1] (SEQUENCE FROM N.A.)
RA   ITOH N., OBATA K.-I., YANAIHARA N., OKAMOTO H.;
RL   NATURE 304:547-549(1983).
RN   [2] (SEQUENCE OF 7-170 FROM N.A.)
RA   GOZES I., BODENER M., SHANI Y., FRIDKIN M.;
RL   PEPTIDES 7 SUPPL. 1:1-6(1986).
RN   [3] (SEQUENCE FROM N.A.)
RA   LINDER S., BARKHEM T., NORBERG A., PERSSON H., SCHALLING M.,
RA   HOEKFELT T., MAGNUSSON G.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 84:605-609(1987).
CC   -!- FUNCTION: VIP CAUSES VASODILATATION, LOWERS ARTERIAL BLOOD
CC       PRESSURE, STIMULATES MYOCARDIAL CONTRACTILITY, INCREASES
CC       GLYCOGENOLYSIS AND RELAXES THE SMOOTH MUSCLE OF TRACHEA, STOMACH
CC       AND GALL BLADDER.
CC   -!- FUNCTION: PHM ALSO CAUSES VASODILATATION.
CC   -!- SIMILARITY: BOTH PEPTIDES BELONG TO THE GLUCAGON FAMILY.
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DR   PIR; A01547; VRHU.
DR   EMBL; J00320; HSVIPMR.
DR   EMBL; M14619; HSVIPHM2.
DR   EMBL; M14620; HSVIPHM3.
DR   EMBL; M14621; HSVIPHM4.
DR   EMBL; M14622; HSVIPHM5.
DR   EMBL; M14623; HSVIPHM6.
DR   PROSITE; PS00260; GLUCAGON.
KW   GLUCAGON FAMILY; CLEAVAGE ON PAIR OF BASIC RESIDUES; SIGNAL;
KW   AMIDATION; HORMONE; INTESTINE.
FT   SIGNAL        1     20
FT   PEPTIDE      81    107       INTESTINAL PEPTIDE PHM-27.
FT   PEPTIDE     125    152       VASOACTIVE INTESTINAL PEPTIDE.
FT   MOD_RES     107    107       AMIDATION (G-108 PROVIDE AMIDE GROUP).
FT   MOD_RES     152    152       AMIDATION (G-153 PROVIDE AMIDE GROUP).
FT   CONFLICT    136    136       R -> G (IN REF. 3).
SQ   SEQUENCE   170 AA;  19168 MW;  150235 CN;
     MDTRNKAQLL VLLTLLSVLF SQTSAWPLYR APSALRLGDR IPFEGANEPD QVSLKEDIDM
     LQNALAENDT PYYDVSRNAR HADGVFTSDF SKLLGQLSAK KYLESLMGKR VSSNISEDPV
     PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI LNGKRSSEGE SPDFPEELEK
//