ID IBP_CARCR Reviewed; 110 AA. AC P00993; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 08-NOV-2023, entry version 97. DE RecName: Full=Chelonianin; DE AltName: Full=Basic protease inhibitor; DE AltName: Full=RTPI; OS Caretta caretta (Loggerhead sea turtle). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; OC Americhelydia; Chelonioidea; Cheloniidae; Caretta. OX NCBI_TaxID=8467; RN [1] RP PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1. RC TISSUE=Egg white; RA Kato I., Tominaga N.; RT "Trypsin-subtilisin inhibitor from red sea turtle eggwhite consists of two RT tandem domains -- one Kunitz -- one of a new family."; RL Fed. Proc. 38:832-832(1979). CC -!- FUNCTION: The first domain inhibits trypsin; the second one inhibitis CC subtilisin. CC -!- CAUTION: As the paper only indicates the species as 'red sea turtle', CC the species indicated here is therefore an inference. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; A01224; TITTOR. DR AlphaFoldDB; P00993; -. DR SMR; P00993; -. DR MEROPS; I02.022; -. DR MEROPS; I17.004; -. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR CDD; cd00109; Kunitz-type; 1. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR002223; Kunitz_BPTI. DR InterPro; IPR036880; Kunitz_BPTI_sf. DR InterPro; IPR020901; Prtase_inh_Kunz-CS. DR InterPro; IPR008197; WAP_dom. DR PANTHER; PTHR46751; EPPIN; 1. DR PANTHER; PTHR46751:SF1; WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 6A; 1. DR Pfam; PF00014; Kunitz_BPTI; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR PRINTS; PR00759; BASICPTASE. DR SMART; SM00131; KU; 1. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57362; BPTI-like; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS00280; BPTI_KUNITZ_1; 1. DR PROSITE; PS50279; BPTI_KUNITZ_2; 1. DR PROSITE; PS51390; WAP; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Protease inhibitor; KW Pyrrolidone carboxylic acid; Serine protease inhibitor. FT CHAIN 1..110 FT /note="Chelonianin" FT /id="PRO_0000155409" FT DOMAIN 8..58 FT /note="BPTI/Kunitz inhibitor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031" FT DOMAIN 60..105 FT /note="WAP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT SITE 18..19 FT /note="Reactive bond for trypsin" FT MOD_RES 1 FT /note="Pyrrolidone carboxylic acid" FT /evidence="ECO:0000269|Ref.1" FT DISULFID 8..58 FT /evidence="ECO:0000250" FT DISULFID 17..41 FT /evidence="ECO:0000250" FT DISULFID 33..54 FT /evidence="ECO:0000250" FT DISULFID 67..92 FT /evidence="ECO:0000250" FT DISULFID 76..97 FT /evidence="ECO:0000250" FT DISULFID 80..93 FT /evidence="ECO:0000250" FT DISULFID 86..101 FT /evidence="ECO:0000250" SQ SEQUENCE 110 AA; 11916 MW; 269436243813418E CRC64; QGDKRDICRL PPEQGPCKGR IPRYFYNPAS RMCESFIYGG CKGNKNNFKT KAECVRACRP PERPGVCPKT SGPGICLHGC DSDSDCKEGQ KCCFDGCGYI CLTVAPSGSP //