ID TRPG_SALTY STANDARD; PRT; 530 AA. AC P00905; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 01-MAR-1992 (REL. 21, LAST ANNOTATION UPDATE) DE ANTHRANILATE SYNTHASE COMPONENT II (EC 4.1.3.27) (CONTAINS: GLUTAMINE DE AMIDOTRANSFERASE; ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE DE (EC 2.4.2.18)). GN TRPG-TRPD. OS SALMONELLA TYPHIMURIUM. OC PROKARYOTA; GRACILICUTES; SCOTOBACTERIA; FACULTATIVELY ANAEROBIC RODS; OC ENTEROBACTERIACEAE. RN [1] RP SEQUENCE FROM N.A. RM 84036180 RA HOROWITZ H., VAN ARSDELL J., PLATT T.; RL J. MOL. BIOL. 169:775-797(1983). RN [2] RP SEQUENCE OF 1-200 FROM N.A. RM 81119810 RA NICHOLS B.P., MIOZZARI G.F., VAN CLEEMPUT M., BENNETT G.N., RA YANOFSKY C.; RL J. MOL. BIOL. 142:503-517(1980). CC -!- CATALYTIC ACTIVITY: CHORISMATE + L-GLUTAMINE = ANTHRANILATE + CC PYRUVATE + L-GLUTAMATE. CC -!- CATALYTIC ACTIVITY: ANTHRANILATE + PHOSPHORIBOSYLPYROPHOSPHATE = CC N-5'-PHOSPHORIBOSYL-ANTHRANILATE + PYROPHOSPHATE. CC -!- SUBUNIT: CONTAINS 2 CHAINS WITH DIFFERENT ACTIVITIES: COMPONENT 1 CC CATALYZES THE FORMATION OF ANTHRANILATE USING AMMONIA RATHER THAN CC GLUTAMINE, WHEREAS COMPONENT 2 PROVIDES GLUTAMINE AMIDOTRANSFERASE CC ACTIVITY. CC -!- IN E. COLI AND CERTAIN OTHER BACTERIA, COMPONENT II IS LARGER AND CC ITS C-TERMINAL 2/3 HAS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE CC (EC 2.4.2.18) ACTIVITY. CC -!- PATHWAY: FIRST AND SECOND STEPS IN BIOSYNTHESIS OF TRYPTOPHAN. CC -!- SIMILARITY: TO OTHER TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M30285; STTRPDC1. DR EMBL; J01811; STTRPD. DR PIR; A01126; NNEB2T. DR PROSITE; PS00442; GATASE_TYPE_I. KW TRYPTOPHAN BIOSYNTHESIS; TRANSFERASE; LYASE; MULTIFUNCTIONAL ENZYME; KW GLUTAMINE AMIDOTRANSFERASE. FT INIT_MET 0 0 FT DOMAIN 1 200 GLUTAMINE AMIDOTRANSFERASE. FT DOMAIN 201 530 ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE. FT ACT_SITE 83 83 GATASE (BY SIMILARITY). SQ SEQUENCE 530 AA; 56787 MW; 1317891 CN; ADILLLDNID SFTWNLADQL RTNGHNVVIY RNHIPAQTLI DRLATMKNPV LMLSPGPGVP SEAGCMPELL TRLRGKLPII GICLGHQAIV EAYGGYVGQA GEILHGKASS IEHDGQAMFA GLANPLPVAR YHSLVGSNVP AGLTINAHFN GMVMAVRHDA DRVCGFQFHP ESILTTQGAR LLEQTLAWAQ QKLEPTNTLQ PILEKLYQAQ TLTQQESHQL FSAVVRGELK PEQLAAALVS MKIRGEHPNE IAGAATALLE NAAPFPRPEY LFADIVGTGG DGSNSINIST ASAFVAAACG LKVAKHGNRS VSSKSGSSDL LAAFGINLDM NADKSRQALD ELGVCFLFAP KYHTGLRHAM PVRQQLKTRT LFNVLGPLIN PAHPPLALIG VYSPELVLPI AETLRVLGYQ RAAVVHSGGM DEVSLHAPTI VAELHDGEIK SYQLTAEDFG LTPYHQDQLA GGTPEENRDI LTRLLQGKGD AAHEAAVAAN VAMLMRLHGQ EDLKANAQTV LDVLRNGTAY DRVTALAARG //