ID TRPG$SALTY STANDARD; PRT; 530 AA. AC P00905; DT 01-AUG-1988 (ANNOTATIONS EDITED) DT 21-JUL-1986 (ADAPTED FROM A PIR ENTRY) DE ANTHRANILATE SYNTHASE (EC 4.1.3.27) COMPONENT II (CONTAINS: GLUTAMINE DE AMIDOTRANSFERASE, ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.18) DE (GENE NAME: TRPG-TRPD). OS SALMONELLA TYPHIMURIUM. OC PROKARYOTA. RN [1] (SEQUENCE FROM N.A.) RA HOROWITZ H., VAN ARSDELL J., PLATT T.; RL J. MOL. BIOL. 169:775-797(1983). RN [2] (SEQUENCE OF 1-200 FROM N.A.) RA NICHOLS B.P., MIOZZARI G.F., VAN CLEEMPUT M., BENNETT G.N., RA YANOFSKY C.; RL J. MOL. BIOL. 142:503-517(1980). CC -!- CATALYTIC ACTIVITY: CHORISMATE + L-GLUTAMINE = ANTHRANILATE + CC PYRUVATE + L-GLUTAMATE. CC -!- CATALYTIC ACTIVITY: ANTHRANILATE + PHOSPHORIBOSYLPYROPHOSPHATE = CC N-5'-PHOSPHORIBOSYL-ANTHRANILATE + PYROPHOSPHATE. CC -!- SUBUNIT: CONTAINS 2 CHAINS WITH DIFFERENT ACTIVITIES: COMPONENT 1 CC CATALYZES THE FORMATION OF ANTHRANILATE USING AMMONIA RATHER THAN CC GLUTAMINE, WHEREAS COMPONENT 2 PROVIDES GLUTAMINE AMIDOTRANSFERASE CC ACTIVITY. CC -!- IN E. COLI AND CERTAIN OTHER BACTERIA, COMPONENT II IS LARGER AND CC ITS C-TERMINAL 2/3 HAS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE CC (EC 2.4.2.18) ACTIVITY. CC -!- PATHWAY: FIRST AND SECOND STEPS IN BIOSYNTHESIS OF TRYPTOPHAN. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; A01126; NNEB2T. KW TRYPTOPHAN BIOSYNTHESIS; TRANSFERASE; LYASE; MULTIFUNCTIONAL ENZYME. FT INIT_MET 0 0 FT DOMAIN 1 200 GLUTAMINE AMIDOTRANSFERASE. FT DOMAIN 201 530 ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE. FT ACT_SITE 83 83 BY HOMOLOGY. SQ SEQUENCE 530 AA; 56786 MW; 1317891 CN; ADILLLDNID SFTWNLADQL RTNGHNVVIY RNHIPAQTLI DRLATMKNPV LMLSPGPGVP SEAGCMPELL TRLRGKLPII GICLGHQAIV EAYGGYVGQA GEILHGKASS IEHDGQAMFA GLANPLPVAR YHSLVGSNVP AGLTINAHFN GMVMAVRHDA DRVCGFQFHP ESILTTQGAR LLEQTLAWAQ QKLEPTNTLQ PILEKLYQAQ TLTQQESHQL FSAVVRGELK PEQLAAALVS MKIRGEHPNE IAGAATALLE NAAPFPRPEY LFADIVGTGG DGSNSINIST ASAFVAAACG LKVAKHGNRS VSSKSGSSDL LAAFGINLDM NADKSRQALD ELGVCFLFAP KYHTGLRHAM PVRQQLKTRT LFNVLGPLIN PAHPPLALIG VYSPELVLPI AETLRVLGYQ RAAVVHSGGM DEVSLHAPTI VAELHDGEIK SYQLTAEDFG LTPYHQDQLA GGTPEENRDI LTRLLQGKGD AAHEAAVAAN VAMLMRLHGQ EDLKANAQTV LDVLRNGTAY DRVTALAARG //