ID ATP6_MOUSE STANDARD; PRT; 226 AA. AC P00848; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 18-APR-2006, entry version 51. DE ATP synthase a chain (EC 3.6.3.14) (ATPase protein 6). GN Name=Mtatp6; Synonyms=Atp6, Atpase6, mt-Atp6; OS Mus musculus (Mouse). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82137051; PubMed=7332926; DOI=10.1016/0092-8674(81)90300-7; RA Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.; RT "Sequence and gene organization of mouse mitochondrial DNA."; RL Cell 26:167-180(1981). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c; RA Sato M., Matsuki Y., Oguma T., Tadakuma T.; RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Key component of the proton channel; it may play a CC direct role in the translocation of protons across the membrane. CC -!- CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate + CC H(+)(Out). CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic CC core - and CF(0) - the membrane proton channel. CF(1) has five CC subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) CC has three main subunits: a, b and c. CC -!- SUBCELLULAR LOCATION: Mitochondrion; mitochondrial inner membrane; CC multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the ATPase A chain family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J01420; AAB48649.1; -; Genomic_DNA. DR EMBL; V00711; CAA24085.1; -; Genomic_DNA. DR EMBL; AF093677; AAC63375.1; -; mRNA. DR PIR; A01051; PWMS6. DR Ensembl; ENSMUSG00000064357; Mus musculus. DR MGI; MGI:99927; mt-Atp6. DR InterPro; IPR000568; ATPase_F0_A. DR PANTHER; PTHR11410; ATPsynt_Asub; 1. DR Pfam; PF00119; ATP-synt_A; 1. DR PRINTS; PR00123; ATPASEA. DR TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1. DR PROSITE; PS00449; ATPASE_A; 1. KW CF(0); Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; KW Transmembrane; Transport. FT CHAIN 1 226 ATP synthase a chain. FT /FTId=PRO_0000082139. SQ SEQUENCE 226 AA; 25096 MW; 9941E80F027C4DA7 CRC64; MNENLFASFI TPTMMGFPIV VAIIMFPSIL FPSSKRLINN RLHSFQHWLV KLIIKQMMLI HTPKGRTWTL MIVSLIMFIG STNLLGLLPH TFTPTTQLSM NLSMAIPLWA GAVITGFRHK LKSSLAHFLP QGTPISLIPM LIIIETISLF IQPMALAVRL TANITAGHLL MHLIGGATLV LMNISPPTAT ITFIILLLLT ILEFAVALIQ AYVFTLLVSL YLHDNT //