ID ATP6_MOUSE STANDARD; PRT; 226 AA. AC P00848; DT 21-JUL-1986 (Rel. 01, Created) DT 21-JUL-1986 (Rel. 01, Last sequence update) DT 01-MAR-2002 (Rel. 41, Last annotation update) DE ATP synthase A chain (EC 3.6.3.14) (Protein 6). GN MTATP6 OR MT-ATP6 OR ATP6 OR ATPASE6. OS Mus musculus (Mouse). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=82137051; PubMed=7332926; RA Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.; RT "Sequence and gene organization of mouse mitochondrial DNA."; RL Cell 26:167-180(1981). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=BALB/c; RA Sato M., Matsuki Y., Oguma T., Tadakuma T.; RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: KEY COMPONENT OF THE PROTON CHANNEL; IT MAY PLAY A CC DIRECT ROLE IN THE TRANSLOCATION OF PROTONS ACROSS THE MEMBRANE. CC -!- CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate + CC H(+)(Out). CC -!- SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE CC SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) CC HAS THREE MAIN SUBUNITS: A, B AND C. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- SIMILARITY: BELONGS TO THE ATPASE A CHAIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J01420; AAB48649.1; -. DR EMBL; V00711; CAA24085.1; -. DR EMBL; AF093677; AAC63375.1; -. DR PIR; A01051; PWMS6. DR MGD; MGI:99927; mt-Atp6. DR InterPro; IPR000568; ATP_synt_A. DR Pfam; PF00119; ATP-synt_A; 1. DR PRINTS; PR00123; ATPASEA. DR PROSITE; PS00449; ATPASE_A; 1. KW Hydrogen ion transport; CF(0); Mitochondrion; Transmembrane. SQ SEQUENCE 226 AA; 25095 MW; 9941E80F027C4DA7 CRC64; MNENLFASFI TPTMMGFPIV VAIIMFPSIL FPSSKRLINN RLHSFQHWLV KLIIKQMMLI HTPKGRTWTL MIVSLIMFIG STNLLGLLPH TFTPTTQLSM NLSMAIPLWA GAVITGFRHK LKSSLAHFLP QGTPISLIPM LIIIETISLF IQPMALAVRL TANITAGHLL MHLIGGATLV LMNISPPTAT ITFIILLLLT ILEFAVALIQ AYVFTLLVSL YLHDNT //