ID PA23$NOTSC STANDARD; PRT; 119 AA. AC P00609; DT 01-AUG-1988 (CC LINES EDITED) DT 20-MAR-1987 (ANNOTATIONS EDITED) DT 21-JUL-1986 (ADAPTED FROM A PIR ENTRY) DE PHOSPHOLIPASE A2 (EC 3.1.1.4) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE), DE NOTECHIS 5. OS MAINLAND OR COMMON TIGER SNAKE (NOTECHIS SCUTATUS SCUTATUS). OC EUKARYOTA. RN [1] (SEQUENCE) RA HALPERT J., EAKER D.; RL J. BIOL. CHEM. 251:7343-7347(1976). CC -!- FUNCTION: PA2 CATALYZE THE CALCIUM-DEPENDENT HYDROLYSIS OF THE CC 2-ACYL GROUPS IN 3-SN-PHOSPHOGLYCERIDES. CC -!- CATALYTIC ACTIVITY: PHOSPHATIDYLCHOLINE + H(2)O = 1-ACYLGLYCERYL- CC PHOSPHOCHOLINE + A FATTY ACID ANION. CC -!- NOTECHIS 5 IS LESS TOXIC THAN NOTEXIN BUT HAS A HIGHER SPECIFIC CC PHOSPHOLIPASE ACTIVITY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; A00750; PSNOA5. KW HYDROLASE; LIPID DEGRADATION; CALCIUM. FT ACT_SITE 48 48 BY HOMOLOGY. SQ SEQUENCE 119 AA; 13676 MW; 63242 CN; NLVQFSYLIQ CANHGRRPTR HYMDYGCYCG WGGSGTPVDE LDRCCKIHDD CYSDAEKKGC SPKMSAYDYY CGENGPYCRN IKKKCLRFVC DCDVEAAFCF AKAPYNNANW NIDTKKRCQ //