ID O96525_DROME Unreviewed; 413 AA. AC O96525; DT 01-MAY-1999, integrated into UniProtKB/TrEMBL. DT 01-MAY-1999, sequence version 1. DT 31-JUL-2019, entry version 97. DE SubName: Full=Unpaired protein {ECO:0000313|EMBL:AAC69620.1}; GN Name=upd1 {ECO:0000313|FlyBase:FBgn0004956}; GN Synonyms=os {ECO:0000313|FlyBase:FBgn0004956}, unpaired GN {ECO:0000313|EMBL:AAC69620.1}; GN ORFNames=CG5993 {ECO:0000313|FlyBase:FBgn0004956}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAC69620.1}; RN [1] {ECO:0000313|EMBL:AAC69620.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=9784499; RA Harrison D.A., McCoon P.E., Binari R., Gilman M., Perrimon N.; RT "Drosophila unpaired encodes a secreted protein that activates the JAK RT signaling pathway."; RL Genes Dev. 12:3252-3263(1998). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF072823; AAC69620.1; -; mRNA. DR PRIDE; O96525; -. DR FlyBase; FBgn0004956; upd1. DR eggNOG; ENOG410KB3Y; Eukaryota. DR eggNOG; ENOG4110NP3; LUCA. DR Reactome; R-DME-209209; Formation of the activated receptor complex. DR Reactome; R-DME-209228; Formation of the activated STAT92E dimer and transport to the nucleus. DR Reactome; R-DME-210688; Dephosphorylation by PTP61F phosphatases. DR ChiTaRS; upd3; fly. DR Bgee; FBgn0004956; Expressed in 17 organ(s), highest expression level in embryo. DR GO; GO:0045177; C:apical part of cell; IDA:FlyBase. DR GO; GO:0031012; C:extracellular matrix; TAS:FlyBase. DR GO; GO:0005576; C:extracellular region; IDA:FlyBase. DR GO; GO:0005615; C:extracellular space; IDA:FlyBase. DR GO; GO:0005125; F:cytokine activity; IDA:FlyBase. DR GO; GO:0005102; F:signaling receptor binding; TAS:FlyBase. DR GO; GO:0003383; P:apical constriction; IMP:FlyBase. DR GO; GO:0007350; P:blastoderm segmentation; TAS:FlyBase. DR GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase. DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; HMP:FlyBase. DR GO; GO:0001700; P:embryonic development via the syncytial blastoderm; TAS:FlyBase. DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IMP:FlyBase. DR GO; GO:0007440; P:foregut morphogenesis; IMP:FlyBase. DR GO; GO:0007442; P:hindgut morphogenesis; IMP:FlyBase. DR GO; GO:0060729; P:intestinal epithelial structure maintenance; IMP:FlyBase. DR GO; GO:0036335; P:intestinal stem cell homeostasis; IMP:FlyBase. DR GO; GO:0045475; P:locomotor rhythm; IMP:FlyBase. DR GO; GO:0007616; P:long-term memory; IMP:FlyBase. DR GO; GO:0060031; P:mediolateral intercalation; IMP:FlyBase. DR GO; GO:0045824; P:negative regulation of innate immune response; HMP:FlyBase. DR GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase. DR GO; GO:0038001; P:paracrine signaling; IDA:FlyBase. DR GO; GO:0007538; P:primary sex determination; IMP:FlyBase. DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IDA:FlyBase. DR GO; GO:0016476; P:regulation of embryonic cell shape; IMP:FlyBase. DR GO; GO:0044719; P:regulation of imaginal disc-derived wing size; IMP:FlyBase. DR GO; GO:0007530; P:sex determination; NAS:FlyBase. DR GO; GO:0007540; P:sex determination, establishment of X:A ratio; NAS:FlyBase. DR GO; GO:0017145; P:stem cell division; IMP:FlyBase. DR GO; GO:0008039; P:synaptic target recognition; IMP:FlyBase. DR InterPro; IPR031901; Unpaired. DR Pfam; PF15972; Unpaired; 1. PE 2: Evidence at transcript level; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 413 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004160954. FT REGION 49 76 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 322 347 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 383 413 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 49 66 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 324 341 Basic. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 413 AA; 46926 MW; C987C3599AD5EFE5 CRC64; MARPLLLLLP ILLVLLLAAQ LPHLAEGRST TSSGGLTVID SERLPIRTTS STASAQHPNQ GTIPASAASP RKRHRKRNSN WIDYRNFDEN TTALEWANPC GGNYHPSAGD RFNRQRPRQS FNQLKRHAFR EYRSLNSSQD SAIDIRNMTM WSLHTHNYKF LPKLKPNSTI ALKRWYRNMQ TYVASFAYLR RQQIRWDQRS ITRESSTARE LRELLLSSRR ILCELETAVN QTQSPRQKQR RSGAAVTAVG GTTMLGQQLP QISRLEMNKR LKLRSKTSGP GMGGAASSAS MAAGEADSID MRFVKHHYYD FLRTMYQLLR RDGKRVRSRP RKHHKKQQRS QKKLLQQQQQ LADQLEQRWR SSTLNGKEFN EVSKPVAGGA AGVADVAGVS GGGSNQFARG RRGKRQSKRV QRT //