ID O96525_DROME Unreviewed; 413 AA. AC O96525; DT 01-MAY-1999, integrated into UniProtKB/TrEMBL. DT 01-MAY-1999, sequence version 1. DT 23-MAY-2018, entry version 88. DE SubName: Full=Unpaired protein {ECO:0000313|EMBL:AAC69620.1}; GN Name=upd1 {ECO:0000313|FlyBase:FBgn0004956}; GN Synonyms=os {ECO:0000313|FlyBase:FBgn0004956}, unpaired GN {ECO:0000313|EMBL:AAC69620.1}; GN ORFNames=CG5993 {ECO:0000313|FlyBase:FBgn0004956}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAC69620.1}; RN [1] {ECO:0000313|EMBL:AAC69620.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=9784499; RA Harrison D.A., McCoon P.E., Binari R., Gilman M., Perrimon N.; RT "Drosophila unpaired encodes a secreted protein that activates the JAK RT signaling pathway."; RL Genes Dev. 12:3252-3263(1998). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF072823; AAC69620.1; -; mRNA. DR PRIDE; O96525; -. DR FlyBase; FBgn0004956; upd1. DR eggNOG; ENOG410KB3Y; Eukaryota. DR eggNOG; ENOG4110NP3; LUCA. DR OrthoDB; EOG091G0AG2; -. DR Reactome; R-DME-209209; Formation of the activated receptor complex. DR Reactome; R-DME-209228; Formation of the activated STAT92E dimer and transport to the nucleus. DR Reactome; R-DME-210688; Dephosphorylation by PTP61F phosphatases. DR ChiTaRS; upd3; fly. DR Bgee; FBgn0004956; -. DR ExpressionAtlas; O96525; baseline and differential. DR GO; GO:0045177; C:apical part of cell; IDA:FlyBase. DR GO; GO:0031012; C:extracellular matrix; IDA:FlyBase. DR GO; GO:0005576; C:extracellular region; IDA:FlyBase. DR GO; GO:0005615; C:extracellular space; IDA:FlyBase. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0005578; C:proteinaceous extracellular matrix; TAS:FlyBase. DR GO; GO:0005125; F:cytokine activity; IDA:FlyBase. DR GO; GO:0016015; F:morphogen activity; NAS:FlyBase. DR GO; GO:0005102; F:signaling receptor binding; TAS:FlyBase. DR GO; GO:0042976; P:activation of Janus kinase activity; IDA:FlyBase. DR GO; GO:0003383; P:apical constriction; IMP:FlyBase. DR GO; GO:0007350; P:blastoderm segmentation; TAS:FlyBase. DR GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase. DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; HMP:FlyBase. DR GO; GO:0001700; P:embryonic development via the syncytial blastoderm; TAS:FlyBase. DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IMP:FlyBase. DR GO; GO:0007440; P:foregut morphogenesis; IMP:FlyBase. DR GO; GO:0042078; P:germ-line stem cell division; TAS:FlyBase. DR GO; GO:0007442; P:hindgut morphogenesis; IMP:FlyBase. DR GO; GO:0060729; P:intestinal epithelial structure maintenance; IMP:FlyBase. DR GO; GO:0036335; P:intestinal stem cell homeostasis; IMP:FlyBase. DR GO; GO:0007259; P:JAK-STAT cascade; IDA:FlyBase. DR GO; GO:0045475; P:locomotor rhythm; IMP:FlyBase. DR GO; GO:0007616; P:long-term memory; IMP:FlyBase. DR GO; GO:0060031; P:mediolateral intercalation; IMP:FlyBase. DR GO; GO:0045824; P:negative regulation of innate immune response; HMP:FlyBase. DR GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase. DR GO; GO:0038001; P:paracrine signaling; IDA:FlyBase. DR GO; GO:0007538; P:primary sex determination; IMP:FlyBase. DR GO; GO:0016476; P:regulation of embryonic cell shape; IMP:FlyBase. DR GO; GO:0044719; P:regulation of imaginal disc-derived wing size; IMP:FlyBase. DR GO; GO:0007530; P:sex determination; NAS:FlyBase. DR GO; GO:0007540; P:sex determination, establishment of X:A ratio; NAS:FlyBase. DR GO; GO:0048103; P:somatic stem cell division; TAS:FlyBase. DR GO; GO:0017145; P:stem cell division; IMP:FlyBase. DR GO; GO:0008039; P:synaptic target recognition; IMP:FlyBase. DR InterPro; IPR031901; Unpaired. DR Pfam; PF15972; Unpaired; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 413 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004160954. FT COILED 338 358 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 413 AA; 46926 MW; C987C3599AD5EFE5 CRC64; MARPLLLLLP ILLVLLLAAQ LPHLAEGRST TSSGGLTVID SERLPIRTTS STASAQHPNQ GTIPASAASP RKRHRKRNSN WIDYRNFDEN TTALEWANPC GGNYHPSAGD RFNRQRPRQS FNQLKRHAFR EYRSLNSSQD SAIDIRNMTM WSLHTHNYKF LPKLKPNSTI ALKRWYRNMQ TYVASFAYLR RQQIRWDQRS ITRESSTARE LRELLLSSRR ILCELETAVN QTQSPRQKQR RSGAAVTAVG GTTMLGQQLP QISRLEMNKR LKLRSKTSGP GMGGAASSAS MAAGEADSID MRFVKHHYYD FLRTMYQLLR RDGKRVRSRP RKHHKKQQRS QKKLLQQQQQ LADQLEQRWR SSTLNGKEFN EVSKPVAGGA AGVADVAGVS GGGSNQFARG RRGKRQSKRV QRT //