ID LY66C_HUMAN Reviewed; 125 AA. AC O95867; Q5SRS8; Q8IY94; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 02-DEC-2020, entry version 153. DE RecName: Full=Lymphocyte antigen 6 complex locus protein G6c; DE Flags: Precursor; GN Name=LY6G6C; Synonyms=C6orf24, G6C, NG24; ORFNames=UNQ1947/PRO4430; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10384126; RA Ribas G., Neville M., Wixon J.L., Cheng J., Campbell R.D.; RT "Genes encoding three new members of the leukocyte antigen 6 superfamily RT and a novel member of Ig superfamily, together with genes encoding the RT regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N RT omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30- RT kb segment of the MHC class III region."; RL J. Immunol. 163:278-287(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=12079290; DOI=10.1006/geno.2002.6794; RA Mallya M., Campbell R.D., Aguado B.; RT "Transcriptional analysis of a novel cluster of LY-6 family members in the RT human and mouse major histocompatibility complex: five genes with many RT splice forms."; RL Genomics 80:113-123(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14656967; DOI=10.1101/gr.1736803; RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., RA Hood L.; RT "Analysis of the gene-dense major histocompatibility complex class III RT region and its comparison to mouse."; RL Genome Res. 13:2621-2636(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Shiina S., Tamiya G., Oka A., Inoko H.; RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."; RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP GLYCOSYLATION, SUBCELLULAR LOCATION, SUBUNIT, GPI-ANCHOR, AND TISSUE RP SPECIFICITY. RX PubMed=17008713; DOI=10.1110/ps.062242606; RA Mallya M., Campbell R.D., Aguado B.; RT "Characterization of the five novel Ly-6 superfamily members encoded in the RT MHC, and detection of cells expressing their potential ligands."; RL Protein Sci. 15:2244-2256(2006). CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:17008713}. CC -!- INTERACTION: CC O95867; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-9088345, EBI-12003442; CC O95867; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-9088345, EBI-10314552; CC O95867; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-9088345, EBI-12898013; CC O95867; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-9088345, EBI-10290130; CC O95867; Q969S6: TMEM203; NbExp=3; IntAct=EBI-9088345, EBI-12274070; CC O95867; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-9088345, EBI-988826; CC O95867; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-9088345, EBI-751210; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17008713}; CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}. CC -!- TISSUE SPECIFICITY: Highly expressed at the leading edges of cells, on CC filopodia. {ECO:0000269|PubMed:17008713}. CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:17008713}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ012008; CAB46081.1; -; Genomic_DNA. DR EMBL; AJ315533; CAC85539.1; -; mRNA. DR EMBL; AF129756; AAD18076.1; -; Genomic_DNA. DR EMBL; BA000025; BAB63379.1; -; Genomic_DNA. DR EMBL; AY359119; AAQ89477.1; -; mRNA. DR EMBL; BX248244; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844216; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR354443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR936239; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759787; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471081; EAX03491.1; -; Genomic_DNA. DR EMBL; BC036302; AAH36302.2; -; mRNA. DR CCDS; CCDS4714.1; -. DR RefSeq; NP_079537.1; NM_025261.2. DR BioGRID; 123284; 9. DR IntAct; O95867; 9. DR STRING; 9606.ENSP00000364978; -. DR GlyGen; O95867; 1 site. DR PhosphoSitePlus; O95867; -. DR BioMuta; LY6G6C; -. DR MassIVE; O95867; -. DR PaxDb; O95867; -. DR PeptideAtlas; O95867; -. DR PRIDE; O95867; -. DR ProteomicsDB; 51108; -. DR Antibodypedia; 27576; 90 antibodies. DR Ensembl; ENST00000375819; ENSP00000364978; ENSG00000204421. DR Ensembl; ENST00000383413; ENSP00000372905; ENSG00000206398. DR Ensembl; ENST00000419939; ENSP00000388591; ENSG00000235452. DR Ensembl; ENST00000428121; ENSP00000411365; ENSG00000228250. DR Ensembl; ENST00000428498; ENSP00000410398; ENSG00000228859. DR Ensembl; ENST00000434915; ENSP00000415732; ENSG00000236183. DR Ensembl; ENST00000448386; ENSP00000409428; ENSG00000235925. DR GeneID; 80740; -. DR KEGG; hsa:80740; -. DR UCSC; uc003nwh.4; human. DR CTD; 80740; -. DR DisGeNET; 80740; -. DR EuPathDB; HostDB:ENSG00000204421.2; -. DR GeneCards; LY6G6C; -. DR HGNC; HGNC:13936; LY6G6C. DR HPA; ENSG00000204421; Group enriched (lymphoid tissue, placenta, skin, tongue). DR MIM; 610435; gene. DR neXtProt; NX_O95867; -. DR OpenTargets; ENSG00000204421; -. DR PharmGKB; PA37830; -. DR eggNOG; ENOG502T0T6; Eukaryota. DR GeneTree; ENSGT00390000000752; -. DR HOGENOM; CLU_1991884_0_0_1; -. DR InParanoid; O95867; -. DR OMA; YNTTCCS; -. DR OrthoDB; 1566894at2759; -. DR PhylomeDB; O95867; -. DR TreeFam; TF337667; -. DR PathwayCommons; O95867; -. DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins. DR BioGRID-ORCS; 80740; 4 hits in 843 CRISPR screens. DR ChiTaRS; LY6G6C; human. DR GenomeRNAi; 80740; -. DR Pharos; O95867; Tbio. DR PRO; PR:O95867; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; O95867; protein. DR Bgee; ENSG00000204421; Expressed in skin of leg and 140 other tissues. DR ExpressionAtlas; O95867; baseline and differential. DR Genevisible; O95867; HS. DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB. DR GO; GO:0042802; F:identical protein binding; IDA:UniProtKB. DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl. DR InterPro; IPR039237; LY6G6C. DR PANTHER; PTHR32149; PTHR32149; 1. PE 1: Evidence at protein level; KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein; KW Membrane; Polymorphism; Reference proteome; Signal. FT SIGNAL 1..18 FT /evidence="ECO:0000255" FT CHAIN 19..99 FT /note="Lymphocyte antigen 6 complex locus protein G6c" FT /id="PRO_0000036176" FT PROPEP 100..125 FT /note="Removed in mature form" FT /evidence="ECO:0000255" FT /id="PRO_0000323019" FT DOMAIN 20..111 FT /note="UPAR/Ly6" FT LIPID 99 FT /note="GPI-anchor amidated serine" FT /evidence="ECO:0000255" FT CARBOHYD 88 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 22..47 FT /evidence="ECO:0000250" FT DISULFID 25..33 FT /evidence="ECO:0000250" FT DISULFID 39..65 FT /evidence="ECO:0000250" FT DISULFID 92..97 FT /evidence="ECO:0000250" FT VARIANT 63 FT /note="L -> M (in dbSNP:rs13214568)" FT /id="VAR_039541" SQ SEQUENCE 125 AA; 13821 MW; 9ED7549894C71311 CRC64; MKALMLLTLS VLLCWVSADI RCHSCYKVPV LGCVDRQSCR LEPGQQCLTT HAYLGKMWVF SNLRCGTPEE PCQEAFNQTN RKLGLTYNTT CCNKDNCNSA GPRPTPALGL VFLTSLAGLG LWLLH //