ID CLD14_HUMAN Reviewed; 239 AA. AC O95500; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 31-OCT-2006, entry version 57. DE Claudin-14. GN Name=CLDN14; ORFNames=UNQ777/PRO1571; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RA Keen T.J., Inglehearn C.F.; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT DFNB29 ASP-85. RC TISSUE=Liver; RX MEDLINE=21097730; PubMed=11163249; DOI=10.1016/S0092-8674(01)00200-8; RA Wilcox E.R., Burton Q.L., Naz S., Riazuddin S., Smith T.N., RA Ploplis B., Belyantseva I., Ben-Yosef T., Liburd N.A., Morell R.J., RA Kachar B., Wu D.K., Griffith A.J., Riazuddin S., Friedman T.B.; RT "Mutations in the gene encoding tight junction claudin-14 cause RT autosomal recessive deafness DFNB29."; RL Cell 104:165-172(2001). RN [3] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta, and Testis; RA Wattenhofer M., Falciola V., Charollais A., Caille D., Borel C., RA Estivill X., Petersen M.B., Antonarakis S.E., Meda P., Reymond A.; RT "Claudin 14 and deafness."; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=20289799; PubMed=10830953; DOI=10.1038/35012518; RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., RA Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., RA Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., RA Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., RA Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., RA Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., RA Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., RA Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., RA Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., RA Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., RA Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., RA Lehrach H., Reinhardt R., Yaspo M.-L.; RT "The DNA sequence of human chromosome 21."; RL Nature 405:311-319(2000). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP VARIANT MET-4. RX MEDLINE=22675606; PubMed=12791041; RX DOI=10.1034/j.1399-0004.2003.00101.x; RA Uyguner O., Emiroglu M., Uzumcu A., Hafiz G., Ghanbari A., Baserer N., RA Yuksel-Apak M., Wollnik B.; RT "Frequencies of gap- and tight-junction mutations in Turkish families RT with autosomal-recessive non-syndromic hearing loss."; RL Clin. Genet. 64:65-69(2003). CC -!- FUNCTION: Plays a major role in tight junction-specific CC obliteration of the intercellular space, through calcium- CC independent cell-adhesion activity (By similarity). CC -!- SUBCELLULAR LOCATION: Cell junction; cell membrane; tight CC junction; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Liver, kidney. Also found in ear. CC -!- DISEASE: Defects in CLDN14 are the cause of an autosomal recessive CC form of nonsyndromic sensorineural deafness (DFNB29) [MIM:605608]. CC -!- SIMILARITY: Belongs to the claudin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ132445; CAA10669.1; -; Genomic_DNA. DR EMBL; AF314090; AAG60052.1; -; mRNA. DR EMBL; AY355348; AAR05858.1; -; mRNA. DR EMBL; AY355349; AAR05859.1; -; mRNA. DR EMBL; AJ566765; CAD97762.1; -; mRNA. DR EMBL; AJ566766; CAD97763.1; -; mRNA. DR EMBL; AY358533; AAQ88897.1; -; mRNA. DR EMBL; AP001726; BAA95509.1; -; Genomic_DNA. DR EMBL; BC012126; AAH12126.1; -; mRNA. DR UniGene; Hs.505146; -. DR Ensembl; ENSG00000159261; Homo sapiens. DR KEGG; hsa:23562; -. DR H-InvDB; HIX0016104; -. DR HGNC; HGNC:2035; CLDN14. DR MIM; 605608; gene+phenotype. DR ArrayExpress; O95500; -. DR RZPD-ProtExp; IOH12590; -. DR RZPD-ProtExp; W1073; -. DR GO; GO:0016021; C:integral to membrane; ISS:UniProtKB. DR GO; GO:0005923; C:tight junction; ISS:UniProtKB. DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB. DR GO; GO:0016338; P:calcium-independent cell-cell adhesion; ISS:UniProtKB. DR GO; GO:0006461; P:protein complex assembly; TAS:ProtInc. DR InterPro; IPR006187; Claudin. DR InterPro; IPR003556; Claudin14. DR InterPro; IPR004031; PMP22_Claudin. DR PANTHER; PTHR12002; Claudin; 1. DR Pfam; PF00822; PMP22_Claudin; 1. DR PRINTS; PR01077; CLAUDIN. DR PRINTS; PR01385; CLAUDIN14. DR PROSITE; PS01346; CLAUDIN; 1. KW Deafness; Disease mutation; Membrane; Polymorphism; Tight junction; KW Transmembrane. FT CHAIN 1 239 Claudin-14. FT /FTId=PRO_0000144769. FT TOPO_DOM 1 7 Cytoplasmic (Potential). FT TRANSMEM 8 28 Potential. FT TOPO_DOM 29 81 Extracellular (Potential). FT TRANSMEM 82 102 Potential. FT TOPO_DOM 103 115 Cytoplasmic (Potential). FT TRANSMEM 116 136 Potential. FT TOPO_DOM 137 162 Extracellular (Potential). FT TRANSMEM 163 183 Potential. FT TOPO_DOM 184 239 Cytoplasmic (Potential). FT VARIANT 4 4 T -> M. FT /FTId=VAR_017227. FT VARIANT 85 85 V -> D (in DFNB29). FT /FTId=VAR_010738. SQ SEQUENCE 239 AA; 25699 MW; DD41652F7FD0E09A CRC64; MASTAVQLLG FLLSFLGMVG TLITTILPHW RRTAHVGTNI LTAVSYLKGL WMECVWHSTG IYQCQIYRSL LALPQDLQAA RALMVISCLL SGIACACAVI GMKCTRCAKG TPAKTTFAIL GGTLFILAGL LCMVAVSWTT NDVVQNFYNP LLPSGMKFEI GQALYLGFIS SSLSLIGGTL LCLSCQDEAP YRPYQAPPRA TTTTANTAPA YQPPAAYKDN RAPSVTSATH SGYRLNDYV //