ID CLDE_HUMAN STANDARD; PRT; 239 AA. AC O95500; DT 30-MAY-2000 (Rel. 39, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE CLAUDIN-14. GN CLDN14. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RA Keen T.J., Inglehearn C.F.; RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=20289799; PubMed=10830953; RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., RA Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Soeda E., RA Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., RA Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., RA Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., RA Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., RA Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., RA Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., RA Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., RA Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., RA Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., RA Lehrach H., Reinhardt R., Yaspo M.-L.; RT "The DNA sequence of human chromosome 21."; RL Nature 405:311-319(2000). CC -!- FUNCTION: COMPONENT OF TIGHT JUNCTION (TJ) STRANDS. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- SIMILARITY: BELONGS TO THE CLAUDIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ132445; CAA10669.1; -. DR EMBL; AP001726; BAA95509.1; -. DR INTERPRO; IPR000729; -. DR INTERPRO; IPR001832; -. DR PFAM; PF00822; PMP22_Claudin; 1. DR PRINTS; PR01077; CLAUDIN. DR PROSITE; PS01346; CLAUDIN; 1. KW Tight junction; Transmembrane. FT TRANSMEM 8 28 POTENTIAL. FT TRANSMEM 82 102 POTENTIAL. FT TRANSMEM 116 136 POTENTIAL. FT TRANSMEM 163 183 POTENTIAL. SQ SEQUENCE 239 AA; 25699 MW; DD41652F7FD0E09A CRC64; MASTAVQLLG FLLSFLGMVG TLITTILPHW RRTAHVGTNI LTAVSYLKGL WMECVWHSTG IYQCQIYRSL LALPQDLQAA RALMVISCLL SGIACACAVI GMKCTRCAKG TPAKTTFAIL GGTLFILAGL LCMVAVSWTT NDVVQNFYNP LLPSGMKFEI GQALYLGFIS SSLSLIGGTL LCLSCQDEAP YRPYQAPPRA TTTTANTAPA YQPPAAYKDN RAPSVTSATH SGYRLNDYV //