ID   OAZ2_HUMAN              Reviewed;         189 AA.
AC   O95190;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   14-DEC-2022, entry version 158.
DE   RecName: Full=Ornithine decarboxylase antizyme 2;
DE            Short=AZ2;
DE            Short=ODC-Az 2;
GN   Name=OAZ2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9782076; DOI=10.1006/geno.1998.5434;
RA   Ivanov I.P., Gesteland R.F., Atkins J.F.;
RT   "A second mammalian antizyme: conservation of programmed ribosomal
RT   frameshifting.";
RL   Genomics 52:119-129(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10352227; DOI=10.1016/s0378-1119(99)00128-6;
RA   Zhou J., Atkins J.F., Gesteland R.F.;
RT   "Structure of human ornithine decarboxylase antizyme 2 gene.";
RL   Gene 232:165-171(1999).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH AZIN2.
RX   PubMed=17900240; DOI=10.1042/bj20071004;
RA   Kanerva K., Makitie L.T., Pelander A., Heiskala M., Andersson L.C.;
RT   "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor
RT   but not an arginine decarboxylase.";
RL   Biochem. J. 409:187-192(2008).
CC   -!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
CC       negatively regulates ODC activity and intracellular polyamine
CC       biosynthesis and uptake in response to increased intracellular
CC       polyamine levels. Binds to ODC monomers, inhibiting the assembly of the
CC       functional ODC homodimers. Does not target the ODC monomers for
CC       degradation, which allows a protein synthesis-independent restoration
CC       of ODC activity (PubMed:17900240). Involved in the translocation of
CC       AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By
CC       similarity). {ECO:0000250|UniProtKB:O08608,
CC       ECO:0000269|PubMed:17900240}.
CC   -!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
CC       homodimerization (By similarity). Interacts with AZIN2; this
CC       interaction disrupts the interaction between the antizyme and ODC1
CC       (PubMed:17900240). {ECO:0000250|UniProtKB:P54368,
CC       ECO:0000269|PubMed:17900240}.
CC   -!- INTERACTION:
CC       O95190; Q01850: CDR2; NbExp=3; IntAct=EBI-1051861, EBI-1181367;
CC       O95190; Q4VX76: SYTL3; NbExp=3; IntAct=EBI-1051861, EBI-2840607;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for Ser-32
CC         and Asp-33. An autoregulatory mechanism enables modulation of
CC         frameshifting according to the cellular concentration of polyamines.;
CC       Name=1;
CC         IsoId=O95190-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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DR   EMBL; AF057297; AAD03265.1; -; mRNA.
DR   CCDS; CCDS58372.1; -. [O95190-1]
DR   RefSeq; NP_002528.1; NM_002537.3. [O95190-1]
DR   AlphaFoldDB; O95190; -.
DR   SMR; O95190; -.
DR   BioGRID; 111001; 11.
DR   IntAct; O95190; 5.
DR   MINT; O95190; -.
DR   STRING; 9606.ENSP00000463013; -.
DR   iPTMnet; O95190; -.
DR   PhosphoSitePlus; O95190; -.
DR   BioMuta; OAZ2; -.
DR   MassIVE; O95190; -.
DR   PaxDb; O95190; -.
DR   PeptideAtlas; O95190; -.
DR   Antibodypedia; 42839; 90 antibodies from 19 providers.
DR   DNASU; 4947; -.
DR   Ensembl; ENST00000326005.10; ENSP00000463013.1; ENSG00000180304.14. [O95190-1]
DR   GeneID; 4947; -.
DR   KEGG; hsa:4947; -.
DR   UCSC; uc002ano.3; human. [O95190-1]
DR   AGR; HGNC:8096; -.
DR   CTD; 4947; -.
DR   DisGeNET; 4947; -.
DR   GeneCards; OAZ2; -.
DR   HGNC; HGNC:8096; OAZ2.
DR   HPA; ENSG00000180304; Low tissue specificity.
DR   MIM; 604152; gene.
DR   neXtProt; NX_O95190; -.
DR   OpenTargets; ENSG00000180304; -.
DR   PharmGKB; PA31885; -.
DR   VEuPathDB; HostDB:ENSG00000180304; -.
DR   eggNOG; KOG4387; Eukaryota.
DR   GeneTree; ENSGT00940000157725; -.
DR   HOGENOM; CLU_085486_2_0_1; -.
DR   InParanoid; O95190; -.
DR   OMA; IVHFRYE; -.
DR   OrthoDB; 1403675at2759; -.
DR   PhylomeDB; O95190; -.
DR   TreeFam; TF314741; -.
DR   PathwayCommons; O95190; -.
DR   Reactome; R-HSA-350562; Regulation of ornithine decarboxylase (ODC).
DR   SignaLink; O95190; -.
DR   BioGRID-ORCS; 4947; 18 hits in 1086 CRISPR screens.
DR   ChiTaRS; OAZ2; human.
DR   GeneWiki; OAZ2; -.
DR   GenomeRNAi; 4947; -.
DR   Pharos; O95190; Tbio.
DR   PRO; PR:O95190; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; O95190; protein.
DR   Bgee; ENSG00000180304; Expressed in left testis and 208 other tissues.
DR   ExpressionAtlas; O95190; baseline and differential.
DR   Genevisible; O95190; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IDA:UniProtKB.
DR   GO; GO:1902268; P:negative regulation of polyamine transmembrane transport; IEA:Ensembl.
DR   GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006595; P:polyamine metabolic process; TAS:ProtInc.
DR   GO; GO:0090316; P:positive regulation of intracellular protein transport; ISS:UniProtKB.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; ISS:UniProtKB.
DR   Gene3D; 3.40.630.60; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR029916; ODC-AZ_2.
DR   InterPro; IPR002993; ODC_AZ.
DR   InterPro; IPR038581; ODC_AZ_sf.
DR   PANTHER; PTHR10279; ORNITHINE DECARBOXYLASE ANTIZYME; 1.
DR   PANTHER; PTHR10279:SF6; ORNITHINE DECARBOXYLASE ANTIZYME 2; 1.
DR   Pfam; PF02100; ODC_AZ; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   PROSITE; PS01337; ODC_AZ; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Polyamine biosynthesis; Reference proteome;
KW   Ribosomal frameshifting.
FT   CHAIN           1..189
FT                   /note="Ornithine decarboxylase antizyme 2"
FT                   /id="PRO_0000220857"
FT   MOD_RES         186
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08608"
FT   VARIANT         70
FT                   /note="P -> L (in dbSNP:rs3751534)"
FT                   /id="VAR_050420"
SQ   SEQUENCE   189 AA;  21011 MW;  66390D87EB30CB8F CRC64;
     MINTQDSSIL PLSNCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD PSLSALIYKD
     EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ SLFVEIPDGL LADGSKEGLL
     ALLEFAEEKM KVNYVFICFR KGREDRAPLL KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP
     LDQNLSDED
//