ID   SLIK5_HUMAN             Reviewed;         958 AA.
AC   O94991; B3KNB8; B4DSH5; Q5VT81;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   10-FEB-2021, entry version 171.
DE   RecName: Full=SLIT and NTRK-like protein 5;
DE   AltName: Full=Leucine-rich repeat-containing protein 11;
DE   Flags: Precursor;
GN   Name=SLITRK5; Synonyms=KIAA0918, LRRC11;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA   Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XII. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 5:355-364(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain, and Brain tumor;
RX   PubMed=14557068; DOI=10.1016/s0378-1119(03)00715-7;
RA   Aruga J., Yokota N., Mikoshiba K.;
RT   "Human SLITRK family genes: genomic organization and expression profiling
RT   in normal brain and brain tumor tissue.";
RL   Gene 315:87-94(2003).
CC   -!- FUNCTION: Suppresses neurite outgrowth. {ECO:0000250}.
CC   -!- INTERACTION:
CC       O94991; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-17240818, EBI-12006120;
CC       O94991; P51800-3: CLCNKA; NbExp=3; IntAct=EBI-17240818, EBI-11980535;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O94991-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O94991-2; Sequence=VSP_056676, VSP_056677;
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the cerebral cortex of
CC       the brain but also at low levels in the spinal cord and medulla.
CC       {ECO:0000269|PubMed:14557068}.
CC   -!- SIMILARITY: Belongs to the SLITRK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA74941.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB020725; BAA74941.1; ALT_INIT; mRNA.
DR   EMBL; AK024251; BAG51280.1; -; mRNA.
DR   EMBL; AK299744; BAG61637.1; -; mRNA.
DR   EMBL; AL603883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471085; EAX08917.1; -; Genomic_DNA.
DR   EMBL; BC098106; AAH98106.1; -; mRNA.
DR   EMBL; BC103509; AAI03510.1; -; mRNA.
DR   CCDS; CCDS9465.1; -. [O94991-1]
DR   RefSeq; NP_056382.1; NM_015567.1. [O94991-1]
DR   RefSeq; XP_005254095.1; XM_005254038.4.
DR   RefSeq; XP_005254096.1; XM_005254039.2.
DR   SMR; O94991; -.
DR   BioGRID; 117513; 13.
DR   IntAct; O94991; 6.
DR   STRING; 9606.ENSP00000366283; -.
DR   GlyGen; O94991; 2 sites.
DR   iPTMnet; O94991; -.
DR   PhosphoSitePlus; O94991; -.
DR   BioMuta; SLITRK5; -.
DR   EPD; O94991; -.
DR   jPOST; O94991; -.
DR   MassIVE; O94991; -.
DR   MaxQB; O94991; -.
DR   PaxDb; O94991; -.
DR   PeptideAtlas; O94991; -.
DR   PRIDE; O94991; -.
DR   ProteomicsDB; 5027; -.
DR   ProteomicsDB; 50619; -. [O94991-1]
DR   Antibodypedia; 2571; 132 antibodies.
DR   Ensembl; ENST00000325089; ENSP00000366283; ENSG00000165300. [O94991-1]
DR   GeneID; 26050; -.
DR   KEGG; hsa:26050; -.
DR   UCSC; uc001vln.4; human. [O94991-1]
DR   CTD; 26050; -.
DR   DisGeNET; 26050; -.
DR   GeneCards; SLITRK5; -.
DR   HGNC; HGNC:20295; SLITRK5.
DR   HPA; ENSG00000165300; Tissue enhanced (brain, fallopian tube, salivary gland).
DR   MIM; 609680; gene.
DR   neXtProt; NX_O94991; -.
DR   OpenTargets; ENSG00000165300; -.
DR   PharmGKB; PA134885524; -.
DR   VEuPathDB; HostDB:ENSG00000165300.7; -.
DR   eggNOG; ENOG502QUVV; Eukaryota.
DR   GeneTree; ENSGT00940000158453; -.
DR   HOGENOM; CLU_012706_1_0_1; -.
DR   InParanoid; O94991; -.
DR   OMA; INYTGVT; -.
DR   OrthoDB; 217854at2759; -.
DR   PhylomeDB; O94991; -.
DR   TreeFam; TF326378; -.
DR   PathwayCommons; O94991; -.
DR   Reactome; R-HSA-388844; Receptor-type tyrosine-protein phosphatases.
DR   BioGRID-ORCS; 26050; 6 hits in 876 CRISPR screens.
DR   ChiTaRS; SLITRK5; human.
DR   GeneWiki; SLITRK5; -.
DR   GenomeRNAi; 26050; -.
DR   Pharos; O94991; Tbio.
DR   PRO; PR:O94991; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; O94991; protein.
DR   Bgee; ENSG00000165300; Expressed in neocortex and 155 other tissues.
DR   Genevisible; O94991; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0043235; C:receptor complex; IDA:MGI.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0030534; P:adult behavior; IEA:Ensembl.
DR   GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR   GO; GO:0072359; P:circulatory system development; IEA:Ensembl.
DR   GO; GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
DR   GO; GO:0007625; P:grooming behavior; IEA:Ensembl.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR   GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   GO; GO:0021756; P:striatum development; IEA:Ensembl.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR043326; Slitrk.
DR   PANTHER; PTHR45773; PTHR45773; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 10.
DR   SMART; SM00082; LRRCT; 2.
DR   PROSITE; PS51450; LRR; 11.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..40
FT                   /evidence="ECO:0000255"
FT   CHAIN           41..958
FT                   /note="SLIT and NTRK-like protein 5"
FT                   /id="PRO_0000032681"
FT   TOPO_DOM        41..664
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        665..685
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        686..958
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          82..103
FT                   /note="LRR 1"
FT   REPEAT          106..127
FT                   /note="LRR 2"
FT   REPEAT          130..151
FT                   /note="LRR 3"
FT   REPEAT          154..175
FT                   /note="LRR 4"
FT   REPEAT          178..199
FT                   /note="LRR 5"
FT   REPEAT          201..222
FT                   /note="LRR 6"
FT   DOMAIN          235..286
FT                   /note="LRRCT 1"
FT   DOMAIN          365..407
FT                   /note="LRRNT"
FT   REPEAT          410..431
FT                   /note="LRR 7"
FT   REPEAT          434..455
FT                   /note="LRR 8"
FT   REPEAT          458..479
FT                   /note="LRR 9"
FT   REPEAT          482..503
FT                   /note="LRR 10"
FT   REPEAT          506..527
FT                   /note="LRR 11"
FT   REPEAT          529..550
FT                   /note="LRR 12"
FT   DOMAIN          563..614
FT                   /note="LRRCT 2"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        644
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..31
FT                   /note="MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVT -> MGAGKHREGGGGDPTSL
FT                   NGCADLIQRRTEIS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056676"
FT   VAR_SEQ         32..272
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056677"
SQ   SEQUENCE   958 AA;  107486 MW;  69E71DC1EE3C568B CRC64;
     MHTCCPPVTL EQDLHRKMHS WMLQTLAFAV TSLVLSCAET IDYYGEICDN ACPCEEKDGI
     LTVSCENRGI ISLSEISPPR FPIYHLLLSG NLLNRLYPNE FVNYTGASIL HLGSNVIQDI
     ETGAFHGLRG LRRLHLNNNK LELLRDDTFL GLENLEYLQV DYNYISVIEP NAFGKLHLLQ
     VLILNDNLLS SLPNNLFRFV PLTHLDLRGN RLKLLPYVGL LQHMDKVVEL QLEENPWNCS
     CELISLKDWL DSISYSALVG DVVCETPFRL HGRDLDEVSK QELCPRRLIS DYEMRPQTPL
     STTGYLHTTP ASVNSVATSS SAVYKPPLKP PKGTRQPNKP RVRPTSRQPS KDLGYSNYGP
     SIAYQTKSPV PLECPTACSC NLQISDLGLN VNCQERKIES IAELQPKPYN PKKMYLTENY
     IAVVRRTDFL EATGLDLLHL GNNRISMIQD RAFGDLTNLR RLYLNGNRIE RLSPELFYGL
     QSLQYLFLQY NLIREIQSGT FDPVPNLQLL FLNNNLLQAM PSGVFSGLTL LRLNLRSNHF
     TSLPVSGVLD QLKSLIQIDL HDNPWDCTCD IVGMKLWVEQ LKVGVLVDEV ICKAPKKFAE
     TDMRSIKSEL LCPDYSDVVV STPTPSSIQV PARTSAVTPA VRLNSTGAPA SLGAGGGASS
     VPLSVLILSL LLVFIMSVFV AAGLFVLVMK RRKKNQSDHT STNNSDVSSF NMQYSVYGGG
     GGTGGHPHAH VHHRGPALPK VKTPAGHVYE YIPHPLGHMC KNPIYRSREG NSVEDYKDLH
     ELKVTYSSNH HLQQQQQPPP PPQQPQQQPP PQLQLQPGEE ERRESHHLRS PAYSVSTIEP
     REDLLSPVQD ADRFYRGILE PDKHCSTTPA GNSLPEYPKF PCSPAAYTFS PNYDLRRPHQ
     YLHPGAGDSR LREPVLYSPP SAVFVEPNRN EYLELKAKLN VEPDYLEVLE KQTTFSQF
//