ID   WDR47_HUMAN             Reviewed;         919 AA.
AC   O94967; A8MX09; Q5TYV7; Q5TYV8; Q5TYV9; Q8IXT7; Q8IYU9;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   10-FEB-2021, entry version 167.
DE   RecName: Full=WD repeat-containing protein 47;
DE   AltName: Full=Neuronal enriched MAP-interacting protein;
DE            Short=Nemitin;
GN   Name=WDR47; Synonyms=KIAA0893;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA   Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XII. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 5:355-364(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC   TISSUE=Brain;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18220336; DOI=10.1021/pr0705441;
RA   Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT   "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT   phosphoproteomic analysis.";
RL   J. Proteome Res. 7:1346-1351(2008).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-285; SER-292 AND SER-297, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [10]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312; SER-422 AND THR-542, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- SUBUNIT: Interacts with MAP1S (via WD repeats). {ECO:0000250}.
CC   -!- INTERACTION:
CC       O94967; P56279: TCL1A; NbExp=3; IntAct=EBI-723239, EBI-749995;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC       Note=Localization along microtubules is mediated by MAP1S.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=O94967-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O94967-2; Sequence=VSP_012093;
CC       Name=3;
CC         IsoId=O94967-3; Sequence=VSP_035045;
CC       Name=4;
CC         IsoId=O94967-4; Sequence=VSP_046727, VSP_035045;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK225781; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAA74916.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB020700; BAA74916.2; ALT_INIT; mRNA.
DR   EMBL; AK289789; BAF82478.1; -; mRNA.
DR   EMBL; AK225781; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BX679664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL449266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471122; EAW56350.1; -; Genomic_DNA.
DR   EMBL; CH471122; EAW56351.1; -; Genomic_DNA.
DR   EMBL; BC034964; AAH34964.1; -; mRNA.
DR   EMBL; BC039254; AAH39254.1; -; mRNA.
DR   CCDS; CCDS30787.1; -. [O94967-3]
DR   CCDS; CCDS44186.1; -. [O94967-4]
DR   CCDS; CCDS44187.1; -. [O94967-1]
DR   RefSeq; NP_001136022.1; NM_001142550.1. [O94967-4]
DR   RefSeq; NP_001136023.1; NM_001142551.1. [O94967-1]
DR   RefSeq; NP_055784.3; NM_014969.5. [O94967-3]
DR   RefSeq; XP_016856186.1; XM_017000697.1. [O94967-1]
DR   BioGRID; 116574; 21.
DR   IntAct; O94967; 15.
DR   MINT; O94967; -.
DR   STRING; 9606.ENSP00000383599; -.
DR   iPTMnet; O94967; -.
DR   PhosphoSitePlus; O94967; -.
DR   BioMuta; WDR47; -.
DR   EPD; O94967; -.
DR   jPOST; O94967; -.
DR   MassIVE; O94967; -.
DR   MaxQB; O94967; -.
DR   PaxDb; O94967; -.
DR   PeptideAtlas; O94967; -.
DR   PRIDE; O94967; -.
DR   ProteomicsDB; 2284; -.
DR   ProteomicsDB; 50587; -. [O94967-1]
DR   ProteomicsDB; 50588; -. [O94967-2]
DR   ProteomicsDB; 50589; -. [O94967-3]
DR   Antibodypedia; 33741; 44 antibodies.
DR   DNASU; 22911; -.
DR   Ensembl; ENST00000361054; ENSP00000354339; ENSG00000085433. [O94967-2]
DR   Ensembl; ENST00000369962; ENSP00000358979; ENSG00000085433. [O94967-1]
DR   Ensembl; ENST00000369965; ENSP00000358982; ENSG00000085433. [O94967-3]
DR   Ensembl; ENST00000400794; ENSP00000383599; ENSG00000085433. [O94967-4]
DR   GeneID; 22911; -.
DR   KEGG; hsa:22911; -.
DR   UCSC; uc001dwi.4; human. [O94967-1]
DR   CTD; 22911; -.
DR   DisGeNET; 22911; -.
DR   GeneCards; WDR47; -.
DR   HGNC; HGNC:29141; WDR47.
DR   HPA; ENSG00000085433; Tissue enhanced (brain).
DR   MIM; 615734; gene.
DR   neXtProt; NX_O94967; -.
DR   OpenTargets; ENSG00000085433; -.
DR   PharmGKB; PA134937302; -.
DR   VEuPathDB; HostDB:ENSG00000085433.15; -.
DR   eggNOG; KOG0641; Eukaryota.
DR   GeneTree; ENSGT00940000155561; -.
DR   HOGENOM; CLU_014985_0_0_1; -.
DR   InParanoid; O94967; -.
DR   OMA; ECHSIFE; -.
DR   OrthoDB; 245263at2759; -.
DR   PhylomeDB; O94967; -.
DR   TreeFam; TF312810; -.
DR   PathwayCommons; O94967; -.
DR   SignaLink; O94967; -.
DR   BioGRID-ORCS; 22911; 3 hits in 877 CRISPR screens.
DR   ChiTaRS; WDR47; human.
DR   GeneWiki; WDR47; -.
DR   GenomeRNAi; 22911; -.
DR   Pharos; O94967; Tdark.
DR   PRO; PR:O94967; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; O94967; protein.
DR   Bgee; ENSG00000085433; Expressed in Ammon's horn and 244 other tissues.
DR   ExpressionAtlas; O94967; baseline and differential.
DR   Genevisible; O94967; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR040067; WDR47.
DR   PANTHER; PTHR19863; PTHR19863; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00668; CTLH; 1.
DR   SMART; SM00667; LisH; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS50896; LISH; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; Cytoskeleton; Developmental protein;
KW   Microtubule; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..919
FT                   /note="WD repeat-containing protein 47"
FT                   /id="PRO_0000051397"
FT   DOMAIN          10..42
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   DOMAIN          45..102
FT                   /note="CTLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT   REPEAT          604..643
FT                   /note="WD 1"
FT   REPEAT          659..698
FT                   /note="WD 2"
FT   REPEAT          706..748
FT                   /note="WD 3"
FT   REPEAT          753..791
FT                   /note="WD 4"
FT   REPEAT          798..837
FT                   /note="WD 5"
FT   REPEAT          840..879
FT                   /note="WD 6"
FT   REPEAT          886..918
FT                   /note="WD 7"
FT   COMPBIAS        425..474
FT                   /note="Gln-rich"
FT   MOD_RES         285
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         289
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CGF6"
FT   MOD_RES         292
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:20068231"
FT   MOD_RES         297
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648"
FT   MOD_RES         312
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         422
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         542
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   VAR_SEQ         54..81
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_012093"
FT   VAR_SEQ         109
FT                   /note="H -> HVRFLFLK (in isoform 4)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_046727"
FT   VAR_SEQ         377
FT                   /note="R -> RS (in isoform 3 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334, ECO:0000303|Ref.3"
FT                   /id="VSP_035045"
FT   CONFLICT        298
FT                   /note="P -> Q (in Ref. 6; AAH39254)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        369
FT                   /note="S -> C (in Ref. 6; AAH39254)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        698
FT                   /note="T -> TVS (in Ref. 6; AAH39254)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        779
FT                   /note="R -> G (in Ref. 6; AAH34964)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        789
FT                   /note="V -> A (in Ref. 6; AAH34964)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   919 AA;  101949 MW;  2BC571E17DB67166 CRC64;
     MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML FLRQLILDGQ
     WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA MSAEDEPQHL EFTMQEAVQC
     LHALEEYCPS KDDYSKLCLL LTLPRLTNHA EFKDWNPSTA RVHCFEEACV MVAEFIPADR
     KLSEAGFKAS NNRLFQLVMK GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL
     DLSLLSWLQN LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR
     RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY PGVQNLSRSL
     MLENTECHSI YEESPERDTP VDAQRPIGSE ILGQSSVSEK EPANGAQNPG PAKQEKNELR
     DSTEQFQEYY RQRLRYQQHL EQKEQQRQIY QQMLLEGGVN QEDGPDQQQN LTEQFLNRSI
     QKLGELNIGM DGLGNEVSAL NQQCNGSKGN GSNGSSVTSF TTPPQDSSQR LTHDASNIHT
     STPRNPGSTN HIPFLEESPC GSQISSEHSV IKPPLGDSPG SLSRSKGEED DKSKKQFVCI
     NILEDTQAVR AVAFHPAGGL YAVGSNSKTL RVCAYPDVID PSAHETPKQP VVRFKRNKHH
     KGSIYCVAWS PCGQLLATGS NDKYVKVLPF NAETCNATGP DLEFSMHDGT IRDLAFMEGP
     ESGGAILISA GAGDCNIYTT DCQRGQGLHA LSGHTGHILA LYTWSGWMIA SGSQDKTVRF
     WDLRVPSCVR VVGTTFHGTG SAVASVAVDP SGRLLATGQE DSSCMLYDIR GGRMVQSYHP
     HSSDVRSVRF SPGAHYLLTG SYDMKIKVTD LQGDLTKQLP IMVVGEHKDK VIQCRWHTQD
     LSFLSSSADR TVTLWTYNG
//