ID RGSB_HUMAN STANDARD; PRT; 467 AA. AC O94810; O75883; DT 15-JUL-1999 (Rel. 38, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 15-JUL-1999 (Rel. 38, Last annotation update) DE REGULATOR OF G-PROTEIN SIGNALING 11 (RGS11). GN RGS11. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN, AND TESTIS; RA SAITO T., SEKI N., MIYAJIMA N.; RT "Homo sapiens regulator of G-protein signaling 11 (RGS11)."; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 99007310. RA SNOW B.E., KRUMINS A.M., BROTHERS G.M., LEE S.-F., WALL M.A., RA CHUNG S., MANGION J., ARYA S., GILMAN A.G., SIDEROVSKI D.P.; RT "A G protein gamma subunit-like domain shared between RGS11 and other RT RGS proteins specifies binding to Gbeta5 subunits."; RL Proc. Natl. Acad. Sci. U.S.A. 95:13307-13312(1998). CC -!- FUNCTION: INHIBITS SIGNAL TRANSDUCTION BY INCREASING THE GTPASE CC ACTIVITY OF G PROTEIN ALPHA SUBUNITS THEREBY DRIVING THEM INTO CC THEIR INACTIVE GDP-BOUND FORM. CC -!- SUBUNIT: HETERODIMER OF A GBETA5 AND A RGS11 SUBUNITS. CC -!- SIMILARITY: BELONGS TO THE RGS FAMILY. CC -!- SIMILARITY: BELONGS TO THE G PROTEIN GAMMA FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB016929; CAB19491.1; -. DR EMBL; AF035153; AAC69175.1; -. DR EMBL; AF035154; AAC69176.1; -. DR MIM; 603895; -. DR PFAM; PF00610; DEP; 1. DR PFAM; PF00615; RGS; 1. DR PROSITE; PS50058; G_PROTEIN_GAMMA; FALSE_NEG. KW Signal transduction inhibitor. FT DOMAIN 32 113 DISHEVELLED/EGL-10/PLECKSTRIN (DEP). FT DOMAIN 219 282 G PROTEIN GAMMA SUBUNIT-LIKE. FT DOMAIN 299 414 RGS. FT CONFLICT 107 123 TPYFWTSTLRPAAELDY -> VRLGGA (IN REF. 1). SQ SEQUENCE 467 AA; 52946 MW; 060681CC CRC32; MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA //