ID RGS11_HUMAN Reviewed; 467 AA. AC O94810; O75883; Q4TT71; Q4TT72; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1999, sequence version 2. DT 09-DEC-2015, entry version 135. DE RecName: Full=Regulator of G-protein signaling 11; DE Short=RGS11; GN Name=RGS11; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RC TISSUE=Brain, and Testis; RA Saito T., Seki N., Miyajima N.; RT "Homo sapiens regulator of G-protein signaling 11 (RGS11)."; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). RX PubMed=9789084; DOI=10.1073/pnas.95.22.13307; RA Snow B.E., Krumins A.M., Brothers G.M., Lee S.-F., Wall M.A., RA Chung S., Mangion J., Arya S., Gilman A.G., Siderovski D.P.; RT "A G protein gamma subunit-like domain shared between RGS11 and other RT RGS proteins specifies binding to Gbeta5 subunits."; RL Proc. Natl. Acad. Sci. U.S.A. 95:13307-13312(1998). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11157797; DOI=10.1093/hmg/10.4.339; RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., RA Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., RA Higgs D.R.; RT "Sequence, structure and pathology of the fully annotated terminal 2 RT Mb of the short arm of human chromosome 16."; RL Hum. Mol. Genet. 10:339-352(2001). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP INTERACTION WITH GBETA5, AND MUTAGENESIS OF SER-245 AND TRP-274. RX PubMed=10339615; DOI=10.1073/pnas.96.11.6489; RA Snow B.E., Betts L., Mangion J., Sondek J., Siderovski D.P.; RT "Fidelity of G protein beta-subunit association by the G protein RT gamma-subunit-like domains of RGS6, RGS7, and RGS11."; RL Proc. Natl. Acad. Sci. U.S.A. 96:6489-6494(1999). CC -!- FUNCTION: Inhibits signal transduction by increasing the GTPase CC activity of G protein alpha subunits thereby driving them into CC their inactive GDP-bound form. CC -!- SUBUNIT: Heterodimer with Gbeta5. Interacts with RGS7BP, leading CC to regulate the subcellular location of the heterodimer formed CC with Gbeta5 (By similarity). {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=O94810-1; Sequence=Displayed; CC Name=2; CC IsoId=O94810-2; Sequence=VSP_023497; CC Name=3; CC IsoId=O94810-3; Sequence=VSP_046724; CC -!- SIMILARITY: Contains 1 DEP domain. {ECO:0000255|PROSITE- CC ProRule:PRU00066}. CC -!- SIMILARITY: Contains 1 G protein gamma domain. {ECO:0000305}. CC -!- SIMILARITY: Contains 1 RGS domain. {ECO:0000255|PROSITE- CC ProRule:PRU00171}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB016929; BAA74751.1; -; mRNA. DR EMBL; AF035153; AAC69175.1; -; mRNA. DR EMBL; AF035154; AAC69176.1; -; mRNA. DR EMBL; AE006463; AAK61221.1; -; Genomic_DNA. DR EMBL; Z69667; CAI95581.1; -; Genomic_DNA. DR EMBL; AC004754; CAI95581.1; JOINED; Genomic_DNA. DR EMBL; Z69667; CAI95582.1; -; Genomic_DNA. DR EMBL; AC004754; CAI95582.1; JOINED; Genomic_DNA. DR EMBL; CH471112; EAW85839.1; -; Genomic_DNA. DR CCDS; CCDS10403.1; -. [O94810-3] DR CCDS; CCDS42088.1; -. [O94810-1] DR CCDS; CCDS66884.1; -. [O94810-2] DR RefSeq; NP_001273414.1; NM_001286485.1. [O94810-2] DR RefSeq; NP_001273415.1; NM_001286486.1. DR RefSeq; NP_003825.1; NM_003834.2. [O94810-3] DR RefSeq; NP_899180.1; NM_183337.2. [O94810-1] DR UniGene; Hs.65756; -. DR ProteinModelPortal; O94810; -. DR SMR; O94810; 11-424. DR BioGrid; 114314; 4. DR IntAct; O94810; 2. DR STRING; 9606.ENSP00000380876; -. DR PhosphoSite; O94810; -. DR BioMuta; RGS11; -. DR PaxDb; O94810; -. DR PRIDE; O94810; -. DR DNASU; 8786; -. DR Ensembl; ENST00000316163; ENSP00000319069; ENSG00000076344. [O94810-3] DR Ensembl; ENST00000359740; ENSP00000352778; ENSG00000076344. [O94810-2] DR Ensembl; ENST00000397770; ENSP00000380876; ENSG00000076344. [O94810-1] DR GeneID; 8786; -. DR KEGG; hsa:8786; -. DR UCSC; uc002cgi.1; human. [O94810-1] DR UCSC; uc010bqs.1; human. [O94810-2] DR CTD; 8786; -. DR GeneCards; RGS11; -. DR HGNC; HGNC:9993; RGS11. DR HPA; HPA041692; -. DR HPA; HPA043039; -. DR MIM; 603895; gene. DR neXtProt; NX_O94810; -. DR PharmGKB; PA34363; -. DR eggNOG; KOG3589; Eukaryota. DR eggNOG; ENOG410YMJD; LUCA. DR GeneTree; ENSGT00760000119142; -. DR HOGENOM; HOG000220864; -. DR HOVERGEN; HBG007404; -. DR InParanoid; O94810; -. DR KO; K16449; -. DR OMA; FPFMRRQ; -. DR OrthoDB; EOG7BZVS5; -. DR PhylomeDB; O94810; -. DR TreeFam; TF351956; -. DR Reactome; R-HSA-418594; G alpha (i) signalling events. DR GeneWiki; RGS11; -. DR GenomeRNAi; 8786; -. DR NextBio; 32948; -. DR PRO; PR:O94810; -. DR Proteomes; UP000005640; Chromosome 16. DR Bgee; O94810; -. DR CleanEx; HS_RGS11; -. DR ExpressionAtlas; O94810; baseline and differential. DR Genevisible; O94810; HS. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0044292; C:dendrite terminus; IEA:Ensembl. DR GO; GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0043234; C:protein complex; IDA:MGI. DR GO; GO:0031681; F:G-protein beta-subunit binding; IPI:UniProtKB. DR GO; GO:0005096; F:GTPase activator activity; TAS:ProtInc. DR GO; GO:0004871; F:signal transducer activity; IEA:InterPro. DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW. DR GO; GO:0043547; P:positive regulation of GTPase activity; TAS:GOC. DR GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc. DR Gene3D; 1.10.10.10; -; 1. DR Gene3D; 1.10.196.10; -; 1. DR Gene3D; 4.10.260.10; -; 1. DR InterPro; IPR000591; DEP_dom. DR InterPro; IPR015898; G-protein_gamma-like_dom. DR InterPro; IPR016137; RGS. DR InterPro; IPR024066; RGS_subdom1. DR InterPro; IPR011991; WHTH_DNA-bd_dom. DR Pfam; PF00610; DEP; 1. DR Pfam; PF00631; G-gamma; 1. DR Pfam; PF00615; RGS; 1. DR PRINTS; PR01301; RGSPROTEIN. DR SMART; SM00049; DEP; 1. DR SMART; SM00224; GGL; 1. DR SMART; SM00315; RGS; 1. DR SUPFAM; SSF46785; SSF46785; 1. DR SUPFAM; SSF48097; SSF48097; 1. DR SUPFAM; SSF48670; SSF48670; 1. DR PROSITE; PS50186; DEP; 1. DR PROSITE; PS50132; RGS; 1. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; Polymorphism; KW Reference proteome; Signal transduction inhibitor. FT CHAIN 1 467 Regulator of G-protein signaling 11. FT /FTId=PRO_0000204210. FT DOMAIN 32 107 DEP. {ECO:0000255|PROSITE- FT ProRule:PRU00066}. FT DOMAIN 219 282 G protein gamma. FT DOMAIN 299 414 RGS. {ECO:0000255|PROSITE- FT ProRule:PRU00171}. FT VAR_SEQ 1 21 Missing (in isoform 3). FT {ECO:0000303|PubMed:9789084}. FT /FTId=VSP_046724. FT VAR_SEQ 107 123 TPYFWTSTLRPAAELDY -> VRLGGA (in isoform FT 2). {ECO:0000303|Ref.1}. FT /FTId=VSP_023497. FT VARIANT 351 351 V -> M (in dbSNP:rs9806942). FT /FTId=VAR_061770. FT VARIANT 427 427 M -> T (in dbSNP:rs739999). FT /FTId=VAR_024606. FT MUTAGEN 245 245 S->A: Diminishes interaction with Gbeta5. FT {ECO:0000269|PubMed:10339615}. FT MUTAGEN 274 274 W->F: Diminishes interaction with Gbeta5. FT {ECO:0000269|PubMed:10339615}. SQ SEQUENCE 467 AA; 52946 MW; 46BEE11D77C2C5F7 CRC64; MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA //