ID DMS4_PACDA STANDARD; PRT; 71 AA. AC O93454; DT 20-AUG-2001 (Rel. 40, Created) DT 20-AUG-2001 (Rel. 40, Last sequence update) DT 20-AUG-2001 (Rel. 40, Last annotation update) DE Dermaseptin PD-3-6 precursor. OS Pachymedusa dacnicolor (Giant mexican leaf frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Bufonoidea; Hylidae; OC Pachymedusa. OX NCBI_TaxID=75988; RN [1] RP SEQUENCE FROM N.A., AND TISSUE SPECIFICITY. RC TISSUE=Skin; RX MEDLINE=98449786; PubMed=9774745; RA Wechselberger C.; RT "Cloning of cDNAs encoding new peptides of the dermaseptin-family."; RL Biochim. Biophys. Acta 1388:279-283(1998). CC -!- FUNCTION: POSSESSES A POTENT ANTIMICROBIAL ACTIVITY AGAINST GRAM- CC POSITIVE AND GRAM-NEGATIVE BACTERIA. PROBABLY ACTS BY DISTURBING CC MEMBRANE FUNCTIONS WITH ITS AMPHIPATHIC STRUCTURE (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: SKIN-SPECIFIC. CC -!- SIMILARITY: BELONGS TO THE DERMASEPTIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ005192; CAA06429.1; -. KW Antibiotic; Multigene family; Cleavage on pair of basic residues; KW Amidation; Signal. FT SIGNAL 1 22 POTENTIAL. FT PROPEP 23 42 POTENTIAL. FT CHAIN 46 68 DERMASEPTIN PD-3-6. FT PROPEP 70 71 POTENTIAL. FT MOD_RES 68 68 AMIDATION (G-69 PROVIDE AMIDE GROUP) FT (POTENTIAL). SQ SEQUENCE 71 AA; 7781 MW; 94FD43979DCBA150 CRC64; MAFLKKSLFL VLFLALVPLS ICEAEKREEE NEEKQEDDDE SEKKRGVVTD LLNTAGGLLG NLVGSLSGGE R //