ID DMS4_PACDA Reviewed; 71 AA. AC O93454; DT 04-MAY-2001, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 18-SEP-2019, entry version 50. DE RecName: Full=Dermaseptin PD-3-6; DE Flags: Precursor; OS Pachymedusa dacnicolor (Giant mexican leaf frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; OC Phyllomedusinae; Pachymedusa. OX NCBI_TaxID=75988; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Skin; RX PubMed=9774745; DOI=10.1016/s0167-4838(98)00202-7; RA Wechselberger C.; RT "Cloning of cDNAs encoding new peptides of the dermaseptin-family."; RL Biochim. Biophys. Acta 1388:279-283(1998). CC -!- FUNCTION: Possesses a potent antimicrobial activity against Gram- CC positive and Gram-negative bacteria. Probably acts by disturbing CC membrane functions with its amphipathic structure (By similarity). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed by the skin glands. CC {ECO:0000269|PubMed:9774745}. CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family. CC Dermaseptin subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ005192; CAA06429.1; -; mRNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW. DR InterPro; IPR004275; Frog_antimicrobial_propeptide. DR InterPro; IPR016322; FSAP. DR Pfam; PF03032; FSAP_sig_propep; 1. DR PIRSF; PIRSF001822; Dermaseptin_precursor; 1. PE 2: Evidence at transcript level; KW Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial; KW Cleavage on pair of basic residues; Secreted; Signal. FT SIGNAL 1 22 {ECO:0000255}. FT PROPEP 23 42 {ECO:0000255}. FT /FTId=PRO_0000007084. FT PEPTIDE 46 68 Dermaseptin PD-3-6. FT /FTId=PRO_0000007085. FT PROPEP 70 71 {ECO:0000255}. FT /FTId=PRO_0000007086. FT MOD_RES 68 68 Glycine amide. {ECO:0000255}. SQ SEQUENCE 71 AA; 7781 MW; 94FD43979DCBA150 CRC64; MAFLKKSLFL VLFLALVPLS ICEAEKREEE NEEKQEDDDE SEKKRGVVTD LLNTAGGLLG NLVGSLSGGE R //