ID DMS4_PACDA STANDARD; PRT; 71 AA. AC O93454; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Dermaseptin PD-3-6 precursor. OS Pachymedusa dacnicolor (Giant mexican leaf frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; OC Phyllomedusinae; Pachymedusa. OX NCBI_TaxID=75988; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Skin; RX MEDLINE=98449786; PubMed=9774745; DOI=10.1016/S0167-4838(98)00202-7; RA Wechselberger C.; RT "Cloning of cDNAs encoding new peptides of the dermaseptin-family."; RL Biochim. Biophys. Acta 1388:279-283(1998). CC -!- FUNCTION: Possesses a potent antimicrobial activity against Gram- CC positive and Gram-negative bacteria. Probably acts by disturbing CC membrane functions with its amphipathic structure (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Expressed by the skin glands. CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family. CC Dermaseptin subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ005192; CAA06429.1; -; mRNA. DR InterPro; IPR004275; Brevenin. DR Pfam; PF03032; Brevenin; 1. KW Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial; KW Cleavage on pair of basic residues; Signal. FT SIGNAL 1 22 Potential. FT PROPEP 23 42 Potential. FT /FTId=PRO_0000007084. FT PEPTIDE 46 68 Dermaseptin PD-3-6. FT /FTId=PRO_0000007085. FT PROPEP 70 71 Potential. FT /FTId=PRO_0000007086. FT MOD_RES 68 68 Glycine amide (G-69 provides amide group) FT (Potential). SQ SEQUENCE 71 AA; 7781 MW; 94FD43979DCBA150 CRC64; MAFLKKSLFL VLFLALVPLS ICEAEKREEE NEEKQEDDDE SEKKRGVVTD LLNTAGGLLG NLVGSLSGGE R //