ID O92593_9HIV1 Unreviewed; 211 AA. AC O92593; DT 01-NOV-1998, integrated into UniProtKB/TrEMBL. DT 01-NOV-1998, sequence version 1. DT 12-SEP-2018, entry version 80. DE RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS01051655}; GN Name=nef {ECO:0000313|EMBL:CAA77077.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:CAA77077.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:CAA77077.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=3715 {ECO:0000313|EMBL:CAA77077.1}; RA Ahmad K.M., Jameel S.; RT "NEF sequences of primary hiv-1 isolates from northern India."; RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. CC -!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS01051624}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS01051622}; Lipid-anchor CC {ECO:0000256|SAAS:SAAS01051622}; Cytoplasmic side CC {ECO:0000256|SAAS:SAAS01051622}. CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. {ECO:0000256|RuleBase:RU000344, CC ECO:0000256|SAAS:SAAS01051605}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y18199; CAA77077.1; -; Genomic_RNA. DR ProteinModelPortal; O92593; -. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR HAMAP; MF_04078; NEF_HIV; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor_sf. DR InterPro; IPR027481; HIV-1_Nef_core_sf. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|SAAS:SAAS01051610}; KW Host membrane {ECO:0000256|SAAS:SAAS01051635}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01051595}; KW Lipoprotein {ECO:0000256|RuleBase:RU000344}; KW Membrane {ECO:0000256|SAAS:SAAS01051602}; KW Myristate {ECO:0000256|RuleBase:RU000344}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|RuleBase:RU000344}. SQ SEQUENCE 211 AA; 24238 MW; 92AB590B99EA60A7 CRC64; MGGKWSKSSI VGWPAIRERM RRTEPAAEPA AEGVGAASQD LDRHGALTSS NTDTNNADCA WLRAQEEEEE VGFPVRPQVP LRPMTFKGAF DLSFFLKEKG GLEGLIYSKK RQEILDLWVY RTQGYFPDWQ NYTPGPGERF PLTFGWCFKL VPVDPREVEE ANEGEDNSLL HPVCQHGMED EHREVLKWKF DSQLALRHRA RELHPEFYKD C //