ID O91183 PRELIMINARY; PRT; 211 AA. AC O91183; DT 01-NOV-1998 (TrEMBLrel. 08, Created) DT 01-NOV-1998 (TrEMBLrel. 08, Last sequence update) DT 01-MAR-2002 (TrEMBLrel. 20, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN). GN NEF. OS Human immunodeficiency virus type 1. OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11676; RN [1] RP SEQUENCE FROM N.A. RA Ahmad K.M.; RT "New sequences of primary HIV-1 isolates from north India."; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RA Jameel S.; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEMS TO DOWN-REGULATE THE CD4(T4) ANTIGEN. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y17883; CAA76912.1; -. DR HSSP; P03406; 1EFN. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR ProDom; PD000031; F-protein; 1. KW AIDS; GTP-binding; Myristate. SQ SEQUENCE 211 AA; 24150 MW; 9B6E893A8832CBF4 CRC64; MGGKWSKSSI VGWPAIRERM RRTEPAAEPA AEGVGAASQD LDRHGALTSS NTDTSNADCA WLRAQEEDEE VGFPVRPQVP LRPMTFKGAF DLSFFLKEKG GLEGLIYSKK RQEILDLWVY HTQGYFPDWQ NYTPGPGTRF PLTFGWCFKL VPVDPREVEE ANEGEDNSLL HPVCQHGMED EHREVLKWKF DSQLARRHIA RELHPEFYKD C //