ID O91183_9HIV1 Unreviewed; 211 AA. AC O91183; DT 01-NOV-1998, integrated into UniProtKB/TrEMBL. DT 01-NOV-1998, sequence version 1. DT 06-JUL-2016, entry version 69. DE RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS00004511}; GN Name=nef {ECO:0000313|EMBL:CAA76912.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:CAA76912.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:CAA76912.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=3714 {ECO:0000313|EMBL:CAA76912.1}; RA Ahmad K.M.; RT "New sequences of primary HIV-1 isolates from north India."; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAA76912.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=3714 {ECO:0000313|EMBL:CAA76912.1}; RA Jameel S.; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. CC -!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS00536203}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00536205}; Lipid-anchor CC {ECO:0000256|SAAS:SAAS00536205}; Cytoplasmic side CC {ECO:0000256|SAAS:SAAS00536205}. CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. {ECO:0000256|RuleBase:RU000344, CC ECO:0000256|SAAS:SAAS00536190}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y17883; CAA76912.1; -; Genomic_RNA. DR ProteinModelPortal; O91183; -. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor. DR InterPro; IPR027481; HIV-1_Nef_core. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|SAAS:SAAS00417561}; KW Host membrane {ECO:0000256|SAAS:SAAS00417568}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00417537}; KW Lipoprotein {ECO:0000256|RuleBase:RU003609}; KW Membrane {ECO:0000256|SAAS:SAAS00417549}; KW Myristate {ECO:0000256|RuleBase:RU003609}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|RuleBase:RU000344}. SQ SEQUENCE 211 AA; 24150 MW; 9B6E893A8832CBF4 CRC64; MGGKWSKSSI VGWPAIRERM RRTEPAAEPA AEGVGAASQD LDRHGALTSS NTDTSNADCA WLRAQEEDEE VGFPVRPQVP LRPMTFKGAF DLSFFLKEKG GLEGLIYSKK RQEILDLWVY HTQGYFPDWQ NYTPGPGTRF PLTFGWCFKL VPVDPREVEE ANEGEDNSLL HPVCQHGMED EHREVLKWKF DSQLARRHIA RELHPEFYKD C //