ID O91183 PRELIMINARY; PRT; 211 AA. AC O91183; DT 01-NOV-1998 (TrEMBLrel. 08, Created) DT 01-NOV-1998 (TrEMBLrel. 08, Last sequence update) DT 01-MAR-2001 (TrEMBLrel. 16, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN). GN NEF. OS Human immunodeficiency virus type 1. OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11676; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=PATIENT # IND.P37; RA Ahmad K.M.; RT "New sequences of primary HIV-1 isolates from north India."; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RC STRAIN=PATIENT # IND.P37; RA Jameel S.; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEMS TO DOWN REGULATE THE CD4(T4) ANTIGEN. NEF CC PROTEIN ACCELERATES VIRULENT PROGRESSION OF AIDS BY ITS CC INTERACTION WITH CELLULAR PROTEINS INVOLVED IN SIGNAL TRANSDUCTION CC AND HOST CELL ACTIVATION. NEF HAS BEEN SHOWN TO BIND SPECIFICALLY CC TO A SUBSET OF THE SRC KINASE FAMILY (BY SIMILARITY). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y17883; CAA76912.1; -. DR HSSP; Q70627; 2NEF. DR InterPro; IPR001558; -. DR Pfam; PF00469; F-protein; 1. KW AIDS; GTP-binding; Myristate. SQ SEQUENCE 211 AA; 24150 MW; 9B6E893A8832CBF4 CRC64; MGGKWSKSSI VGWPAIRERM RRTEPAAEPA AEGVGAASQD LDRHGALTSS NTDTSNADCA WLRAQEEDEE VGFPVRPQVP LRPMTFKGAF DLSFFLKEKG GLEGLIYSKK RQEILDLWVY HTQGYFPDWQ NYTPGPGTRF PLTFGWCFKL VPVDPREVEE ANEGEDNSLL HPVCQHGMED EHREVLKWKF DSQLARRHIA RELHPEFYKD C //