ID O91183 PRELIMINARY; PRT; 211 AA. AC O91183; DT 01-NOV-1998 (TrEMBLrel. 08, Created) DT 01-NOV-1998 (TrEMBLrel. 08, Last sequence update) DT 01-OCT-2003 (TrEMBLrel. 25, Last annotation update) DE Nef protein. GN Name=nef; OS Human immunodeficiency virus 1. OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11676; RN [1] RP SEQUENCE FROM N.A. RA Ahmad K.M.; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RA Jameel S.; RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: NEF has GTPase, GTP-binding and autophosphorylating CC activities. It seems to down-regulate the CD4(T4) antigen. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y17883; CAA76912.1; -. DR HSSP; P03406; 1EFN. DR GO; GO:0005525; F:GTP binding; IEA. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR ProDom; PD000031; HIV_Nef; 1. KW AIDS; GTP-binding; Lipoprotein; Myristate. SQ SEQUENCE 211 AA; 24150 MW; 9B6E893A8832CBF4 CRC64; MGGKWSKSSI VGWPAIRERM RRTEPAAEPA AEGVGAASQD LDRHGALTSS NTDTSNADCA WLRAQEEDEE VGFPVRPQVP LRPMTFKGAF DLSFFLKEKG GLEGLIYSKK RQEILDLWVY HTQGYFPDWQ NYTPGPGTRF PLTFGWCFKL VPVDPREVEE ANEGEDNSLL HPVCQHGMED EHREVLKWKF DSQLARRHIA RELHPEFYKD C //