ID O90241_HBV Unreviewed; 226 AA. AC O90241; DT 01-NOV-1998, integrated into UniProtKB/TrEMBL. DT 01-NOV-1998, sequence version 1. DT 03-MAY-2011, entry version 39. DE SubName: Full=Surface antigen; OS Hepatitis B virus (HBV). OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10407; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=99092774; PubMed=9876947; RA Poovorawan Y., Sripattanawat R., Theamboonlers A., Chongsrisawat V., RA Nuchprayoon I.; RT "Hepatocellular carcinoma: significance of HBV vertical RT transmission."; RL Asian Pac. J. Allergy Immunol. 16:93-103(1998). CC -!- FUNCTION: The large envelope protein exists in two topological CC conformations, one which is termed 'external' or Le-HBsAg and the CC other 'internal' or Li-HBsAg. In its external conformation the CC protein attaches the virus to cell receptors and thereby CC initiating infection. This interaction determines the species CC specificity and liver tropism. It also assume fusion between CC virion membrane and cellular membrane. In its internal CC conformation the protein plays a role in virion morphogenesis and CC mediates the contact with the nucleocapsid like a matrix protein CC (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF072465; AAD13659.1; -; Genomic_DNA. DR PIR; JQ2098; JQ2098. DR PIR; JQ2108; JQ2108. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0019012; C:virion; IEA:UniProtKB-KW. DR GO; GO:0016032; P:viral reproduction; IEA:InterPro. DR InterPro; IPR000349; Hepvir_surfAg. DR Pfam; PF00695; vMSA; 1. PE 3: Inferred from homology; KW Host-virus interaction; Membrane; Transmembrane; Virion. SQ SEQUENCE 226 AA; 25387 MW; 31FBBBDDB8B014BD CRC64; MENIASGLLG PLLVLQAGFF LLKGILTIPQ SLDSWWTSLN FLGGAPTCPG QNSQSQTSNH SPTSCPPICP GYRWMCLRRF IIFLFILLLC LILLLVLLDY QGMLPVCPLL PGSTTTSTGP CKTCTIPAQG TSMFPSCCCT KPSDGNCTCI PIPSSWAFAR FLWEWASVRF SWLSLLVPFV QWFVGLSPTV WLSVIWMMWY WGPRLYNILN PFLPLLPIFF CLWVYI //