ID   O90241_HBV              Unreviewed;       226 AA.
AC   O90241;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   02-MAR-2010, entry version 36.
DE   SubName: Full=Surface antigen;
OS   Hepatitis B virus (HBV).
OC   Viruses; Retro-transcribing viruses; Hepadnaviridae;
OC   Orthohepadnavirus.
OX   NCBI_TaxID=10407;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=99092774; PubMed=9876947;
RA   Poovorawan Y., Sripattanawat R., Theamboonlers A., Chongsrisawat V.,
RA   Nuchprayoon I.;
RT   "Hepatocellular carcinoma: significance of HBV vertical
RT   transmission.";
RL   Asian Pac. J. Allergy Immunol. 16:93-103(1998).
CC   -!- FUNCTION: The large envelope protein exists in two topological
CC       conformations, one which is termed 'external' or Le-HBsAg and the
CC       other 'internal' or Li-HBsAg. In its external conformation the
CC       protein attaches the virus to cell receptors and thereby
CC       initiating infection. This interaction determines the species
CC       specificity and liver tropism. It also assume fusion between
CC       virion membrane and cellular membrane. In its internal
CC       conformation the protein plays a role in virion morphogenesis and
CC       mediates the contact with the nucleocapsid like a matrix protein
CC       (By similarity).
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DR   EMBL; AF072465; AAD13659.1; -; Genomic_DNA.
DR   PIR; JQ2098; JQ2098.
DR   PIR; JQ2108; JQ2108.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016032; P:viral reproduction; IEA:InterPro.
DR   InterPro; IPR000349; Hepvir_surfAg.
DR   Pfam; PF00695; vMSA; 1.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Virion.
SQ   SEQUENCE   226 AA;  25387 MW;  31FBBBDDB8B014BD CRC64;
     MENIASGLLG PLLVLQAGFF LLKGILTIPQ SLDSWWTSLN FLGGAPTCPG QNSQSQTSNH
     SPTSCPPICP GYRWMCLRRF IIFLFILLLC LILLLVLLDY QGMLPVCPLL PGSTTTSTGP
     CKTCTIPAQG TSMFPSCCCT KPSDGNCTCI PIPSSWAFAR FLWEWASVRF SWLSLLVPFV
     QWFVGLSPTV WLSVIWMMWY WGPRLYNILN PFLPLLPIFF CLWVYI
//